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Oral Pathology > Chapter 14 > Flashcards

Chapter 14 Flashcards

1
Q

What is the syndrome that experiences a defect in type I collagen maturation?

A

Osteogenesis imperfecta.

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2
Q

What is the most common type of inherited bone disease?

A

Osteogenesis imperfecta.

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3
Q

Describe the bone seen with osteogenesis imperfecta.

A

Thin cortex, fine trabeculation, diffuse osteoporosis.

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4
Q

What is the disease that is a skeletal disorder with a marked increase in bone denisty? (Two names)

A

Osteopetrosis or marble bone disease.

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5
Q

What cell fails to function properly in osteopetrosis?

A

Osteoclasts.

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6
Q

What is the likely Dx?

A

Osteopetrosis.

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7
Q

What is the likely Dx?

A

Osteopetrosis.

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8
Q

What is the syndrome complex characterized by dental and clavicle abnormalities?

A

Cleidocranial dysplasia.

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9
Q

What is the likely Dx?

A

Cleidocranial dysplasia.

Key is the numerous unerupted permanent and supernumerary teeth.

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10
Q

What is the term for an area of hematopoietic marrow that produces a radiolucency?

A

Focal Osteoporotic Marrow Defect.

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11
Q

What is the likely Dx?

A

Focal osteoporotic marrow defect.

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12
Q

What is the term for an area of increased radiodensity that is of unknown cause and cannot be attributed to anything else?

A

Idiopathic osteosclerosis.

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13
Q

What is the likely Dx?

A

Idiopathic osteosclerosis. NOTE he said this will be a CPC.

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14
Q

Couple of notes for Idiopathic osteosclerosis.

A

Do not confuse with condensing osteitis which is associated with an infection.

Do not confuse with focal cemento-osseous dysplasia which will have a radiolucent rim.

Do no confuse with cementoblastoma which will be fused with the tooth.

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15
Q

T/F: A radiolucent rim surrounds the finding in idiopathic osteosclerosis.

A

False.

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16
Q

What is the disease that is characterized by abnormal resorption and deposition of bone?

A

Paget’s disease of bone.

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17
Q

What is a common complaint of Paget’s disease?

A

Bone pain.

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18
Q

What bones are most commonly affected in Paget’s disease?

A

Vertebrae, pelvis, skull, femur.

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19
Q

Some one comes in with the complain that, “their hat will not fit.” What is the possible reasoning?

A

Paget’s disease leading to progressive increase in head circumference.

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20
Q

What disease is said to have a cotton wool or cotton roll appearance radiographically?

A

Paget’s disease.

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21
Q

What is the likely Dx?

A

Paget’s disease. cotton wool appearance and hypercementosis.

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22
Q

What will the serum levels consit of with someone that has Paget’s disease?

A

High elevations of serum alkaline phosphatase levels and normal calcium and phosphorus levels.

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23
Q

T/F Central giant cell granuloma is a non-neoplastic lesion.

A

True.

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24
Q

Where is central giant cell granuloma typically seen?

A

Anterior Jaw crossing the midline.

25
Q

What is the likely Dx?

A

Central giant cell granuloma. note that it is crossing the midline.

26
Q

What is the likely Dx?

A

Cherubism.

27
Q

What is the term for a benign, empty or fluid filled cavity within bone?

A

Traumatic bone cyst/simple bone cyst NOTE that the cyst is a misnomer because it is not epithelial lined.

28
Q

What is the likely Dx? HINT teeth respond normally.

A

Traumatic bone cyst.

29
Q

What is the term for an intraosseous accumulation of blood-filled spaces surrounded by connective tissue?

A

Aneurysmal bone cyst.

Once again, not a true cyst.

30
Q

What is the term for a diverse group of processes characterized by replacement of normal bone by fibrous tissue containing a mineralized product?

What are the exampls of them?

A

Fibro-osseous lesions.

Fibrous dysplasia, cemento-osseous dysplasia, ossifying fibroma.

31
Q

What is the syndrome that will have a radiograph with the frosted glass look?

A

Fibrous dysplasia.

32
Q

What is the likely Dx?

A

Fibrous dysplasia with the frosted glass look.

Specifically with monostotic form.

33
Q

Fibrous dysplasia is a sporadic condition resulting from what?

A

Postzygotic mutation.

34
Q

What are the types of fibrous dyspasia?

A

Monostotic and Polystotic

Polystotic broken into Jaffe-Lichtenstein and McCune-Albright syndromes.

35
Q

What form of fibrous dysplasia accounts for 80% of the cases?

A

Monostotic.

36
Q

Describe the two syndromes of polystotic fibrous dysplasia.

A

Jaffe-Lichtenstein syndrome: Cafe au lait spots

McCune-Albright syndrome: Cafe au lait spots and multiple endocrinopathies.

37
Q

What is the most common fibro-osseous lesions encountered in clinical practice?

What are the types? Describe them.

A

Cemento-osseous dysplasia.

Focal: Exhibits a single sight of involvement and 90% occur in females. P_eriapical:_ Involves PA region of anterior mandible. Multiple foci are present. 90% female, 70% african american. Average age 40. F__orid: Multilpe focal involvement not limited to the anterior mandible. 90% female 90% African American. Tendency to be bilateral and symmetrical.

38
Q

What is the likely Dx?

A

Periapical cemento-osseous dysplasia.

39
Q

What is the likely Dx?

A

Focal cemento-osseous dysplasia.

40
Q

What is the likely Dx?

A

Florid cemento-osseous dysplasia.

41
Q

What is the term for a true neoplasm with significant growth potential that will show a reverse tear drop radiographically?

A

Ossifying fibroma.

42
Q

How is juvenile ossifying fibroma distinguished from ossifying fibroma?

A

Age of patient, most common site of involvement, and clinical behavior.

As a general rule, the younger the patient, the more aggressive the tumor.

43
Q

What is the term for a symptom complex characterized by colonic polyps and adenocarcinoma?

A

Gardner syndrome.

44
Q

The bowl polyps of gardner syndrome will transform into what?

A

Adenocarcinoma.

45
Q

What are the dental abnormalities seen in gardners syndrome?

A

Supernumerary teeth.

46
Q

How do you differentiate osteoblastomas from osteoid osteomas?

A

Osteiod osteomas produce prostiglandins and will therefore have pain relieved by aspirin and are smaller than 2 cm. Osteoblastomas are larger.

47
Q

What is the term for an odontogenic neoplasm of cementoblasts?

A

Cementoblastoma.

48
Q

What is the likely Dx?

A

Cementoblastoma. Note surrounded by a thin RL rim.

49
Q

What is the term for a rare, benign, non-neoplastic development of cartilaginous nodules within the synovial membrane?

A

Synovial Chondromatosis.

50
Q

What is the likely Dx?

A

Synovial chondromatosis.

51
Q

What is the term for a mesenchymal malignancy where cells have the ability to produce osteoid or immature bone?

A

Osteosarcoma.

52
Q

What is the disease which will present with the sunburst appearance?

A

Osteosarcoma.

53
Q

What is the term for a triangular elevation in the periosteum?

A

Codman’s triangle.

54
Q

What is the likely Dx?

A

Osteosarcoma. Sunburst pattern.

55
Q

What is a primary malignant tumor of bone and the 3rd most common osseous neoplasm?

A

Ewing Sarcoma.

56
Q

What is the most common form of cancer involving bone?

A

Metastatic carcinoma.

57
Q

What are the most common origins of metastatic cancer metastisized to the jaw?

A

Breast, lung, thyroid, prostate, kidney.

58
Q

What is the distinctive pattern of anesthesia associated with mets to the mandible in metastatic carcinoma?

A

Numb-chin syndrome due to the involvement of the IA.

59
Q

What is life expectancy with patients Dx with metastatic cancer?

A

1 yr.

Oral Pathology (17 decks)

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