Chapter 10 Flashcards
What is the term for a benign proliferation of stratified squamous epithelium?
Squamous papilloma.
What type of virus causes squamous papilloma?
DNA HPV types 6 & 11.
Define Virulance and Infectivity.
Virulence = Ability of virus to overcome body’s defenses & cause disease
Infectivity = Ability to establish infection from one person to another horizontally
What is the differential Dx for squamous papilloma?
Verruca vulgaris, Condyloma acuminatum, and verruciform xanthoma.
What is the likely Dx?
Squamous papilloma
What is the likely Dx?
Squamous papilloma
What is the likely Dx?
Squamous papilloma
What type of virus causes Verruca vulgaris?
HPV 2, 4, 6, 40. NOTE most common on skin.
What viruses cause condyloma acuminatum? What is another name for it, and how is it contracted?
HPV 6, 11, 16, 18, 31. Also called venereal wart and is and STD.
What is the likely Dx?
At what stage of life would this likely appear?
Multifocal epithelial hyperplasia AKA Heck’s disease. Appears in childhood.
What viruses cause multifocal epithelial hyperplasia?
HPV 13 & 32.
What type of disease is caused by the DNA poxvirus?
What will the histology look like?
Molluscum contagiosum.
Histology will contain molluscum bodies AKA Henderson-Paterson bodies.
What is the term for an acquired, benign proliferation of epidermal basal cells of unknown etiology?
Seborrheic Keratosis.
What is the likely Dx?
Molluscum contagiosum.
What is the likely Dx?
Seborrheic Keratosis. NOTE, will not occur in the mouth.
What is the term for the sudden appearance of numerous seborrheic keratoses with puritus and what is it associated with?
Leser-Trelat sign, it is an indication of internal malignancy.
What is an ephelis?
A freckle. NOTE become more pronounced with sun exposure.
What is the term for a brown macule resulting from chronic UV light damage to skin?
Actinic lentigo. NOTE no change of intensity with UV expsure.
What is the likely Dx?
Ephelis.
What is the likely Dx?
Actinic lentigo.
What is the term for a benign cutaneous melanocytic hyperplasia?
Lentigo simplex.
What is the likely Dx?
Lentigo simplex. NOTE does not change with sunlight.
What is the term for an acquired, symmetrical, hormonally-driven hyperpigmentation of the sun-exposed skin of the face?
What is it commonly associated with?
Melasma.
Pregnancy.
What is the likely Dx?
Melasma.
What is the term for the oral counter part of an ephelis?
Labial melanotic macule or oral melanotic macule.
What is the most common site for an oral melanotic macule?
Vermilion zone of the lower lip.
Why is it important to biopsy an oral melanotic macule?
Because the non malignant transformation is potential, but clinically cannot be distinguished from early melanoma.
What is the likely Dx?
Labial melanotic macule.
What is the likely Dx?
Oral melanotic macule.
What causes an oral melanotic macule?
Brown asympomatic macule produced by a focal increase in melanin deposition.
What is an acquired pigmentation of the oral mucosa, characterized by dendritic melanocytes throughout the epithelium?
Oral melanoacanthoma.
What is the likely Dx?
Oral melanoacanthoma.
What population will have a presence of oral melanoacanthoma most often?
What does it seem to be caused by?
African American and females due to hormones.
Seems to be caused by trauma.
What is the common name for a nevus?
Mole.
What is the most commonly recognized nevus?
Acquired melanocytic nevus.
What is the likely Dx?
Aqcuired melanocytic nevus.
What is the term for a benign, localized proliferation of cells from the neural crest?
Acquired melanocytic nevus.
Acquired melanocytic nevus has a predilection for where?
Palate.
What is the histology of an acquired melanocytic nevus?
The superficial cells are organized into small, round aggregates termed Theques.
What is the likely Dx?
Intraoral melanocytic nevus.
What is a common feature of a congenital melanocytic nevus?
Hypertrichosis (excess hair)
What is the likely Dx?
Halo Nevus.
What is the likely Dx?
Blue nevus.
What are the two forms of a blue nevus?
Common: 2nd most frequent nevus in oral cavity. Predilection for dorsa of hands and feet, scalp, face. Occurs in children, less than 1 cm in diameter.
Cellular: 50% seen on buttock, slow growing.
What causes a blue nevus to appear blue?
Tyndall effect. Melanin particles deep to the surface.
What is an intraoral white leasion that does not rub off?
Leukoplakia.