Chapter 10 Flashcards
What endocrine requirements must be met so spermatozoa can be produced?
1) adequate secretion of GnRH from hypothalamus
2) FSH and LH secretion from the anterior lobe of the pituitary
3) secretion of gonadal steroids (testosterone and estradiol)
What does luteinizing hormone act on?
Leydig cells within the testes
What do leydig cells synthesize and what is this converted into?
progesterone into testosterone
What does successful testis function require?
pulsatile GnRH secretion, high concentrations of testosterone in the seminiferous tubule, low concentrations of testosterone in a systemic blood, and adequate LH receptors in Leydig cells
What do sertoli cells secrete?
inhibin
What else do the testes secrete?
estradiol
What is the female equivalent of leydig cells in the male?
follicular theca interna cells
What is the female equivalent of sertoli cells in the male?
follicular granulosal cells
What do sertoli cells convert?
testosterone to estradiol
What type of relationship does estradiol and testosterone have on the hypothalamus in the male?
negative feedback
What are the goals of spermatogenesis?
1) provide a continual supply of male gametes, genetic diversity, provide sperm for reproduction and an immunologically privileged site for developing germ cells.
What is the process of producing spermatozoa?
spermatogenesis
Where does spermatogenesis take place?
seminiferous tubules
How much more testosterone should be in testes than circulation for normal spermatogenesis?
100-500 x
Testosterone in circulation keeps what from happening?
negative feedback
What are the three phases of spermatogenesis?
Proliferation, meiosis, differentiation
What does the proliferation phase consist of?
mitotic divisions of spermatogonia and stem cell renewal
What does meiotic phase consist of?
2 meiotic divisions (meiosis 1 and 2) that are for genetic diversity and haploid spermatids
What does the differentiation phase consist of?
Head, mid piece, and flagellum
Where spermatogonia located in?
basal compartment of the seminiferous epithelium
What are the three types of spermetogina?
A1-A4,I, and B-spermatogonia
What is the last division of proliferation?
primary spermatocyctes
What is reduced in the meiotic phase?
chromosomes
What are chromosomes reduced too?
haploid state
What do primary spermatocytes do?
Immediately enter meiosis 1
What takes place in meiosis 1?
crossing over results that are in a random assortment of different segments of each chromosome
How much time does prophase of meiotic division take up of entire spermatogenic process
30% (long process)
What germ cell type has the longest lifespan?
primary spermatocyte
What happens after the first meiotic division?
secondary spermatocyte rapidly undergoes the second meiotic division
What does the second meiotic division result in?
haploid spherical spermatids
What is the role of spermatozoon?
deliver male’s genetic material to an oocyte during fertilization and forms cells capable of fertilization
What happens to these haploid spermatids?
their nucleus becomes highly condensed, the acrosome forms, and the cells become motile