Chap 5: Bone (clinical aspect) (exam 2) Flashcards
Somatotropin influences what
Bone growth
Somatotropin increases the numbers of what cells?
osteoblasts and fibroblasts
If somatotropin is low, what happens to bone density
it will be low
What is scurvy caused by?
a vit. C deficiency
Scurvy affects what?
Collagen I fibers
Scurvy reduces what?
bony matrix and bone development
Scurvy delays what process
bone healing
Rickets is caused by what?
a vitamin D deficiency
Osteomalacia is caused by what?
a prolonged vitamin D deficiency in adults
in Osteomalacia newly formed bone doesn’t what?
does not ossify properly which forms weak bones
Osteoporosis primarily effects what cells?
osteoblasts and osteoclasts
what are three signs of osteoporosis?
- curvature of the spine
- severe back pain
- decreases in height
what are the two types of osteoporosis
- postmenopausal
2. age-related
Postmenopausal osteoporosis effects women over what age?
50
Postmenopausal osteoporosis is caused by what?
decreased estrogen levels
Does age-related osteoporosis affect women or men more frequently?
affects the both of them
Age-related osteoporosis is due to low levels of what?
Somatotropin (HGH)
estrogen reduces the life span of what cell while increases the lifespan of what cell?
Decreases osteoclast lifespan
increases osteoblast lifespan
estrogen stimulates osteoblasts to secrete what?
osteoid
estrogen slows bone what?
bone remodeling
If there is decreased estrogen, what is believed?
osteoclasts dig deeper resorption cavities that osteoblasts can’t fill
Estrogen replacement protected women from fracture but this is eliminated in women who do what?
smoke
Smokers have less effective absorption of what?
calcium
Smokers tend to have an earlier what than nonsmokers?
earlier menopause
The relationship between smoking and osteoporosis is very clear. T/F
False it is unclear
what are some factors leading to osteoporosis?
long use of glucocorticoids antacid use w/Al high protein diet excessive thyroid use anticonvulsant
what are three steps to prevent Osteoporosis
- Balanced diet
- weight bearing exercise
- healthy life choices