chap 5: Bone (bone remodeling and repair) (exam 2) Flashcards
in young people during remodeling development exceeds what
resorption
in adults, after epiphyseal growth plate closure, what is in equilibrium?
development and resorption
cancellous bone remodeling in adults is influenced by what
bone marrow cells
compact bone remodeling in adults is influenced by what
systemic factors from endosteum and osteogenic periosteum
What is the typical process of bone repair
fracture then bleeding, granulation tissue arises, osteoprogenitor cells become active, osteoprogenitor cells move into granulation tissue, blood vessels come back to area then bone develops
bone fracture is damage to what?
tissue, matrix and much cell death
After the initial break bleeding, clotting and the shut down of blood vessels to the area occur leading to what?
a decrease of O2 to the area and more cell death
After the blood vessels shut down to the damaged area granulation tissue will develop causing which type of cells to migrate to the area
osteoprogenitor cells divide and come to the area
Osteoprogenitor cells and osteoblasts can be found on the living edges and boney collar for the first what?
first 48 hours (stabilization)
Osteoprogenitor cells will soon move into the granulation tissue below. With the decreased oxygen to that area the osteoprogenitor cells are forced to differentiate into what
chondrogenic cells
once osteoprogenitor cells become chondrogenic cels they will turn into what? in order to secrete what?
turn into chondroblasts with secrete cartilage matrix
the chondroblasts that secrete cartilage matrixes will form what?
forms fibrocartilagenous mix which will then form some chondrocytes
after the fibrocartilagenous mix forms blood vessels will eventually what?
grow back to the injured area.
this increased oxygen to the fibrocartilagenous mix causes the chondrocytes and blasts to do what?
causes them to die
with the increased O2 to the fibrocartilagenous mix any chondrogenic cells will turn back into what
osteoprogenitor cells and then osteoblasts which produce one matrix
