Ch 9 Toxicity of Chemical and Physical Agents Flashcards
1
Q
xenobiotics
A
exogenous chemicals in the environment that may be absorbed into the body through, inhalation, ingestion, and skin contact
2
Q
detoxification phase I
A
hydrolysis, oxidation, reduction
xenobiotic to primary metabolite
3
Q
detoxification phase II
A
glucuronidation, sulfation, methylation, conjugation
primary metabolite to secondary metabolite
4
Q
CYP
A
most important catalyst of phase I rxn
catalyzes rxn that either detoxify xenobiotics or convert xenobiotics into active compounds that cause cellular injury
leads to the production of ROS
5
Q
inducers of CYP
A
environmental chemicals, drugs, smoking, alcohol, hormones
6
Q
inhibitor of CYP
A
fasting or starvation
