Ch 6 Flashcards

1
Q

Define Extracellular matrix

A

A large network of proteins and other molecules that surround, support, and give structure to cells and tissues in the body

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2
Q

Define Axial

A

The word “Axial” is taken from the word “axis” and refers to the fact that the bones are located close to or along the central “axis” of the body

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3
Q

Define Appendicular

A

relating to a limb or limbs

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4
Q

Define Interstitial

A

situated within but not restricted to or characteristic of a particular organ or tissue —used especially of fibrous tissue. 2 : affecting the interstitial tissues of an organ or part interstitial hepatitis

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5
Q

Define Organic

A

An organic compound is a substance that contains both carbon and hydrogen

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6
Q

Define Inorganic

A

An inorganic compound is a substance that does not contain both carbon and hydrogen

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7
Q

Define Mesenchyme

A

a loosely organized, mainly mesodermal embryonic tissue which develops into connective and skeletal tissues, including blood and lymph

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8
Q

Define Calcification

A

the hardening of tissue or other material by the deposition of or conversion into calcium carbonate or some other insoluble calcium compounds.

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9
Q

Define Brittle

A

hard but liable to break or shatter easily

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10
Q

Define Handedness

A

the most visible manifestation of laterality, a characteristic of the human brain that localizes certain functions to either the right or left hemisphere

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11
Q

Define Hyaline cartilage

A

a translucent bluish-white type of cartilage present in the joints, the respiratory tract, and the immature skeleton

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12
Q

Define Fibrocartilage

A

cartilage that contains fibrous bundles of collagen, such as that of the intervertebral disks in the spinal cord

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13
Q

Give the following information about skeletal cartilage.
Characteristics –

Matrix – 

Cells – 

Lacunae –

Perichondrium –

A

Consists primarily of water (60-80%) / Consists of chondrocytes (cartilage cells) / which are located in a space in the matrix called the lacuna (“cavity) / Has a lot of extracellular matrix / Resilient tissue / Skeletal cartilage contains no blood vessels or nerves / Is surrounded by the perichondrium (“around the cartilage”): Dense irregular connective tissue / Contains blood vessels for nutrient delivery

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14
Q

Know where to find the following cartilages in the skeletal system and state their functions:
a. Hyaline cartilage

b. Elastic cartilage
c. Fibrocartilage

A

A) Fetal skeleton / Near/around joints / Epiphyseal plate / Nose, trachea, larynx / Articular, costal, andrespiratory cartilage
Provides support, flexibility, and resilience / Contains only collagen fibers

B)Epiglottis / External ear (auditory canal) / provides strength, and elasticity, and maintains the shape of certain structure such as the external ear

C)Intervertebral discs / Menisci of the knee joint / Resists tensile (stretching) and compressional forces

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15
Q

Identify the two major regions of the skeleton, know the bones in each and state the general function
a.

b.
A

Axial skeleton: Skull, vertebral column, rib cage(Torso minus waist bones)

Appendicular skeleton: Bones of upper and lower limbs / Girdles attaching limbs to axial skeleton

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16
Q

Know the five categories of bone shapes and be able to classify any bone into the correct category.
a.

b.

c.

d.

e.
A

long bones: These bones are longer than they are wide. Long bones are used for movement. Muscles pull on long bones and cause them to move. / Example: Femur, tibia, humerus, ulna, radius, phalanges and fibula

short bones: These are cube-like in appearance, being as long as they are wide. They provide limited gliding motion and primarily serve as shock absorbers. / Example: Carpals and tarsals

flat bones: These are thin bones that function to protect the tissues and organs of the body. Flat bones also provide a large area for the attachment of muscles and tendons. / Example: Skull/Cranium, which protects the brain, the Sternum, which protects the heart, and the Ribs, which protect the lungs.

irregular bones: These are irregular in shape. The many protrusions on an irregular bone serve to function as a site for muscle attachment. / Example: The Vertebrae

sesamoid bones: These are small bones that are usually embedded within tendons. They function to protect the tendon from friction as it rubs against bony surfaces. / Example: The Patella

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17
Q

Know the 6 functions of bone
a.

b.  
c.  
d.  
e.  

f.
A
support and protection
movement
hemopoiesis: blood cell production
triglyceride (fat) storage
storage of mineral and energy reserves
hormone production (specifically osteocalcin)
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18
Q

Describe the two textures of bone tissue. Name their structural units.
a. Compact bone –

b.  Spongy bone –
A

Compact: Dense outer layer; smooth and solid
Spongy (cancellous or trabecular): Honeycomb of flat pieces of bone deep to compact called trabeculae (“little beams”) (ex. vertebrae bones)

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19
Q

Describe the general structure of all short, irregular and flat bones. Include diploe

A

-Thin plates of spongy bone covered by compact bone
-Diploë: Internal spongy bone of flat bones
-Plates sandwiched between connective tissue membranes
Periosteum (outer layer)
Endosteum
-Contain bone marrow but no marrow cavity
-No shaft or epiphyses
-Hyaline cartilage covers the articular surfaces

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20
Q
Know the structures of a typical long bone and state their functions:
Diaphysis-
Medullary cavity-
Yellow marrow – 
Epiphysis – 
Epiphyseal line – 
Epiphyseal plate – 
Periosteum – 
Fibrous layer – 
Osteogenic layer – 
Nutrient foramen – 
Sharpey’s fibers – 
Endosteum –
A

Diaphysis- shaft
Medullary cavity- hollow space in diaphysis containing yellow marrow
Yellow marrow – made mostly of fat and contains stem cells that can become cartilage, fat, or bone cells
Epiphysis – knobby end
Epiphyseal line – the line marking the site of an epiphyseal plate that has has stopped growing and become ossified.
Epiphyseal plate – a thin layer of cartilage that lies between the epiphyses and metaphyses, and is where the growth of long bones takes place
Periosteum – external coving (irregular dense connective tissue)
Fibrous layer – the external layer of the articular capsule is attached to the whole circumference of the articular end of each bone entering into the joint, and thus entirely surrounds the articulation
Osteogenic layer – highly cellular containing progenitor cells that develop into osteoblasts
Nutrient foramen – a small tunnel through the cortex of a long bone containing a nutrient artery which supplies the bone
Sharpey’s fibers – any of the thready processes of the periosteum that penetrate the tissue of the superficial lamellae of bones
Endosteum – internal covering

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21
Q

Where does Hematopoiesis occur in infants? In adults

A

In infants and children, it may also continue in the spleen and liver.
for adults it occurs primarily in bone marrow

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22
Q

What are bone markings? State their general functions

A

Sites of muscle, ligament, and tendon attachment on external surfaces / Superficial surfaces of bones reflect stresses on them

Bone markings are very important since they allow for identification of bones and bony pieces, enable joints to form, enable bones to slide past each other, enable bones to lock in place, and provide places for muscle and connective tissues to attach and provide structural support

23
Q

Identify 4 projections that form joints (Table 6.1). Know examples

A

Head: Bony expansion carried on a narrow neck. / Example: Head of femur
Facet: Smooth nearly flat articular surface. / Example: Superior process and facet
Condyle: Rounded articular projection. / Example: Medial condyle of femur
Ramus: Arm-like bar of bone. / Example: Ramus of the mandible

24
Q

Identify 8 projections for muscle & ligament attachment. Know examples

A

Tuberosity: Large rounded projections may be roughened
Crest: Narrow ridge of bone usually prominent
Trochanter: Very large, blunt, irregularly shaped process(on femur)
Line: Narrow ridge of bone; less prominent than a crest
Tubercle: small rounded projection or process
epicondyle: Raised are or above a condyle
Spine: Sharp, slender, often pointed projection
Process: any bone prominence

25
Q

Identify 4 depressions or openings for blood vessels and nerves. Know examples

A

Groove: Furrow / ex. jaw line

fissure: Narrow, slit-like opening / ex. behind eyes
foramen: round or oval opening through a bone
notch: indention at the edge of a structure

26
Q

Identify the following depressions and state their functions. Know examples of each.
a. Meatus

b. Sinus
c. Fossa
A

A)Canal-like passageway / ex. ear hole

B)Cavity within a bone, filled with air and lined with mucous membrane / ex. nasal cavity

C)Shallow, basin-like depression in a bone, often serving as an articular surface

27
Q

Identify the four types of cells found in bone tissue and state their functions

A
  • Osteoblasts: bone forming cells
  • Osteocytes: Monitor and maintain bone matrix / act as stress or strain sensors
  • Bone lining cells: Flat cells on bone surfaces believed to help maintain matrix
  • Osteoclasts: Derived from hematopoietic stem cells that become macrophages / Giant, multinucleate phagocytic cells for bone resorption
28
Q

Identify and describe the microscopic structural unit of compact bone. State the function

A

The microscopic structural unit of compact bone is called an osteon, or Haversian system. Each osteon is composed of concentric rings of calcified matrix called lamellae / It provides protection and strength to bones

29
Q

Define the following:
Lamella, lamellar bone

Haversian (central) canal

Volkmann’s (perforating) canal

Lacunae

Canaliculi

Interstitial lamellae

Circumferential lamellae
A
  • Collagen fibers in adjacent rings that run in different directions / Bone withstands stress and resists twisting
  • central to entire structural and functional unit, contains blood vessels and nerves that supply the bone
  • run parallel to and connect the central canals, also containing blood vessels and nerves. Lined with endosteum at right angles to central canal
  • spaces within the matrix of the bone where osteocytes reside
  • relatively small channels that connect adjacent lacunae and the central canal. These communicating channels allow for metabolic interactions between osteocytes. Contain blood vessels and nerve fibers
  • partial (incomplete) lamellae that are “left-over” portions of an osteon that is undergoing reconstruction. Fill gaps between forming osteons
  • rings of bone just deep to the periosteum and superficial to the endosteum. Extend around entire surface of the diaphysis. Resist twisting of long bone
30
Q

Describe Spongy bone. State the locations and function of spongy bone

A

Honeycomb of flat pieces of bone deep to compact called trabeculae (“little beams”) / located on the insides of bones behind compact bone

31
Q

Identify the organic components of bone. What is the function of osteoid

A
  • Includes cells and osteoid: Osteogenic cells, osteoblasts, osteocytes, bone-lining cells, and osteoclasts
  • Osteoid - 1/3 of organic bone matrix secreted by osteoblasts: Made of ground substance (proteoglycans and glycoproteins) / Collagen fibers / Contributes to structure; provides tensile strength and flexibility
32
Q

What are sacrificial bonds? State their function

A

Resilience of bone due to sacrificial bonds in or between collagen molecules / Stretch and break easily on impact to dissipate energy and prevent fracture / If no addition trauma, bonds re-form

33
Q

List the inorganic substances found in the matrix of bone

A

Hydroxyapatites (mineral salts)

34
Q

Define Hydroxyapatites & state the function

A

65% of bone by mass / Mainly of tiny calcium phosphate crystals in and around collagen fibers / Responsible for hardness and resistance to compression

35
Q

Define ossification, osteogenesis

A

the formation and development of bone tissue

36
Q

Know 3 forms of Osteogenesis and when they occur in humans

A

Osteoclasts
Intramembranous ossification
Endochondral ossification

37
Q

Identify the two types of embryonic bone formation. Identify the bones formed from each method.
a.

b.
A
  • Intramembranous ossification develops from fibrous membrane to produce flat bones of the skull, some facial bones, the mandible and central portion of clavicle. Bones are called membrane bones.
  • Endochondral ossification begins with a hyaline cartilage model and produces the majority of bones in the body. Bones are called cartilage (endochondral) bones.
38
Q

What are the stages of endochondral ossification?
a.

b.

c.

d.

e.
A

A) Bone collar forms around the diaphysis of the hyaline cartilage model.
B) Cartilage in the center of the diaphysis calcifies and then develops cavities
C) The periosteal bud invades the internal cavities and spongy bone forms.
D) The diaphysis elongates and a medullary cavity forms. Secondary ossification centers appear in the epiphyses.
E) The epiphyses ossify. Hyaline cartilage remains only in the epiphyseal plates and articular cartilage.

39
Q

How is intramembraneous ossification different

A

It begins within fibrous connective tissue membranes formed by mesenchymal cells, while endochondral ossification begins with a hyaline cartilage model

40
Q

Where does growth of a long bone take place in the growing child

A

Depending on the bone, epiphyseal plate ossification occurs between the ages of 10 and 25 years.

41
Q

Know the 5 zones of the Epiphyseal plate and what takes place.

A
  • Resting (quiescent) zone: Cartilage on epiphyseal side of epiphyseal plate / Relatively inactive
  • Proliferation (growth) zone: Cartilage on diaphysis side of epiphyseal plate / Rapidly divide pushing epiphysis away from diaphysis (lengthening)
  • Hypertrophic zone: Older chondrocytes closer to diaphysis and their lacunae enlarge and erode (interconnecting spaces)
  • Calcification zone: Surrounding cartilage matrix calcifies, chondrocytes die and deteriorate
  • Ossification (osteogenic) zone: Chondrocyte deterioration leaves long spicules of calcified cartilage at epiphysis-diaphysis junction / Spicules eroded by osteoclasts / Covered with new bone by osteoblasts / Ultimately replaced with spongy bone
42
Q

Identify the hormones that regulate bone growth in childhood

A

growth hormone released by the anterior pituitary gland, also known as somatotropin

43
Q

Identify the hormones that regulate bone growth at puberty and state their function

A

-sex hormones
males: testosterone turned into estrogen
females: estrogen
-Thyroid hormone — ensures that the skeleton retains proper proportions
-Calcitonin— produced by the parafollicular cells in the thyroid / Promotes Ca2+ deposition and inhibits osteoclast activity
-Parathyroid hormone — secreted by chief cells of the parathyroid / increases blood Ca2+ levels / encourages bone reabsorption
-Leptin: Hormone released by adipose tissue / Role in bone density regulation / Inhibits osteoblasts in animals
-Serotonin:
Neurotransmitter regulating mood and sleep / Secreted into blood after eating / Interferes with osteoblast activity / Serotonin reuptake inhibitors (e.g., Prozac) cause lower bone density

44
Q

Know the 2 mechanisms of bone remodeling in the adult. Identify the bone cells of each.
a.

b.
A

A)Bone resorption: Function of osteoclasts / Break down matrix and secrete lysosomal enzymes that digest matrix / Destroyed via apoptosis when complete

B) deposition: New matrix deposit by osteoblasts / Requires mechanical signals, Ca2+ & P, matrix proteins, alkaline phosphatase

45
Q

Identify two types of control over bone remodeling

A

Parathyroid lands creating Parathyroid hormone (PTH)-maintaining Ca2+ homeostasis by increasing Ca2+ numbers
Calcitonin-maintaining Ca2+ homeostasis by decreasing Ca2+ numbers

46
Q

Know the normal level of blood calcium. State the functions of Ca+2

A
  • Amount in blood tightly regulated (9-11 mg/dl)
  • important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization.
47
Q

Describe the hormonal control system for maintaining Ca+2 homeostasis when levels are too low

A
  • Stimulus-falling blood Ca2+ levels
  • Parathyroid glands creating Parathyroid hormone (PTH)
  • PTH increases
  • Osteoclasts degrade bone matrix and release CA2+ into blood
  • Calcium homeostasis achieved
48
Q

Identify two mechanical stressor that stimulate bone remodeling

A

the production of new bone matrix by osteoblasts and the destruction of old bone by osteoclasts: occurs when signals come from hormones and stress-sensing osteocytes

49
Q

What is the premise of Wolff’s law

A

natural healthy bones will adapt and change to adapt to the stress that it is subjected to. For example, if the bones are subjected to heavier and heavier loads, they will naturally reconstruct themselves to accommodate that weight. This is how bones typically respond to stress

50
Q

Give explanatory examples of how Wolff’s law applied to bone remodeling

A

a bone growing back after a fracture to the hardness/flexible level that the stress last needed to fracture the bone is no longer enough to do so now.

51
Q

Identify common causes of bone fractures

A
Fall from a height.
Trauma.
Motor vehicle accidents.
Direct blow.
Child abuse.
Repetitive forces, such as those caused by running, can cause stress fractures of the foot, ankle, tibia, or hip.
52
Q

Describe the classifications of bone fracture and recognize examples of each

A
  • Spiral: ragged break occurs when excessive twisting forces are applied to a bone / common sports injury
  • Comminuted: bone fragments into three or more pieces / common in older people with brittle bones
  • Greenstick: bone breaks incompletely, much in the way a green twig breaks. only one side of the shaft breaks; the other side bends / common in children
  • Depressed: broken bone portion is pressed inward / typical of a skull fracture
  • Epiphyseal: Epiphysis separates from the diaphysis along the epiphyseal plate / occurs when cartilage cells are dying and calcification of the matrix is occurring
  • compression: bone is crushed / common in porous bone subjected to extreme trauma (spinal bone)
53
Q

. Identify the 4 stages of bone tissue repair for a simple fracture. State the major events of each stage.
1.

2.

4.

A

1) A bone fracture hematoma (blood clot) occurs
2) A fibrocartilaginous (soft) callus forms
3) A bony (hard) callus replaces the soft callus
4) The bone is remodeled

54
Q

Describe the differences between:
a. Osteomalacia

b. Ricketts
c. Osteoporosis
d. Paget’s disease
A

A)Occurs in adults - bones are inadequately mineralized / Soft bones / Pain upon bearing weight

B)Occurs in children - analogous to Osteomalacia / Bowed legs and other bone deformities

C)Characterized by low bone mass / Bone reabsorption outpaces bone deposition / Deterioration of microscopic architecture of bony skeleton / Occurs most often in women after menopause due to loss of estrogen

D)Characterized by excessive rate of bone deposition / Haphazard bone deposition / Abnormally high ratio of immature woven bone to mature compact bone / Bones become soft & weak