Ch. 26 MOA Flashcards
Interferes with hepatic synthesis of vitamin K dependent clotting factors (II, VII, IX, and X)
warfarin
Binds selectively to antithrombin III (AT III). This binding potentiates the neutralization of active factor X (Xa).
fondaparinux
In low doses, this drug prevents the conversion of prothrombin to thrombin by its effects on factor Xa
heparin
In high doses, this drug neutralizes thrombin, preventing the conversion of fibrinogen to fibrin.
heparin
What is the antidote to heparin?
protamine sulfate
Potentiate the inhibitory effect of anti-thrombin on factor Xa and inhibit factor 5A.
tinzaparin
enoxaparin
dalteparin
This can be administered if toxicity of warfarin occurs.
Vitamin K
Irreversibly acetylate’s platelet COX, decreasing the formation of TXa2.
aspirin
Decreases the release of ADP and TXa2 from platelets so platelets do not aggregate.
dipyridamole
Irreversibly inhibit ADP receptors on platelets.
clopidogrel
ticlopidine
Reversibly block glycoprotein receptors and therefore inhibit the binding of fibrinogen to those sites.
tirofiban
eptifibatide
abciximab
Inhibits the breakdown of a clot.
aminocaproic acid
Increases factor eight which increases clot formation. Also increases platelet aggregation and is used to treat diabetes insipidus.
demopressin
Used for the treatment of hemophilia or von Willebrand’s disease.
Anti-fibrinolytic drugs
Activate plasminogen to plasmin (an enzyme that is capable of dissolving clots by digesting fibrin)
streptokinase
urokinase
