Ch 25 Drugs for Muscle Spasms

Question 1

Localized muscle spasm is treated with ___.

Answer 1

centrally acting muscle relaxants and over-the-counter analgesics such as acetaminophen or NSAIDs

Question 2

Spasticity is treated with four drugs:

Answer 2

baclofen,
diazepam,
dantrolene, and
tizanidine

Question 3

All centrally acting muscle relaxants produce generalized

___.

Answer 3

CNS depression

Question 4

___ is less effective than other available drugs and can cause fatal hepatic
necrosis. Accordingly, the risk for harm usually exceeds
benefits.

Answer 4

Chlorzoxazone, a central muscle relaxant,

Question 5

__ relieves spasticity by mimicking the inhibitory

actions of GABA in the CNS.

Answer 5

Baclofen

Question 6

__ acts directly on muscle to promote relaxation.

Answer 6

Dantrolene

Question 7

Abrupt discontinuation of intrathecal baclofen can lead to __(3)__.

Answer 7

rhabdomyolysis,
multiple organ system failure, and
death

Question 8

With prolonged use, dantrolene can cause potentially fatal __.

Answer 8

liver damage.

Monitor liver function and minimize dosage and duration of treatment.

Question 9

In addition to relief of spasticity, dantrolene is used to

treat __.

Answer 9

malignant hyperthermia, a potentially fatal condition

caused by succinylcholine and general anesthetics.