Ch 2: Principals of Drug Action

Question 1

Pharmacokinetics

Answer 1

the study of a drug during absorption, distribution, metabolism, and excretion

Question 2

Absorption

Answer 2

the passage of drugs from the site into the bloodstream, it is the first step in the drug action

Question 3

Distribution

Answer 3

After a drug is transported from the bloodstream to the sight of action

Question 4

Metabolism

Answer 4

the bio transformation mostly in the liver by converting the drug into a water soluble compound so the body can be able to be excreted

Question 5

Excretion

Answer 5

is the body way of removing the products of ordinary cell processes

Question 6

Detoxify

Answer 6

Eliminate substances that are toxic to the body an older adult with kidney disease is at increased risk of toxicity from exposures of high doses to a drug.

Question 7

Factors that Affect Drug Action

Answer 7

Age, size, diet,sex, genetic factors, pathological conditions,psychological factors, route of administration, time of administration, drug taking history, environmental conditions, food and drug interactions.

Question 8

food and Drug interactions

Answer 8

calcium-decreases the absorbtion of antiiotics
Grapefruit- affect the absorbtion of certain colesteral medications
green leafy veggies-decrease the effect of anti coagulants

Question 9

Allergy

Answer 9

abnormal response because a person has developed antibodies against a drug. when a person takes the allergy causing drug called the antigen the antibodies attack it

Question 10

Histamine

Answer 10

responsible for the symptoms usually seen in allergic reactions

Question 11

Anaphylaxis

Answer 11

is an extreme hypersensitivity reaction to a previously encountered antigen

Question 12

Idiosyncrasy

Answer 12

Opposite of expected effect, stop Medication,

Question 13

Tolerance

Answer 13

lessened effect of a drug, increase dose of change medication

Question 14

Cumulation

Answer 14

stronger effect,stop medication

Question 15

Toxicity

Answer 15

diverse symptoms effecting different organs, stop medication

Question 16

Synergism

Answer 16

stronger effect when more than one drug taken

Question 17

Antagonism

Answer 17

weaker effect when more than one drug taken

Question 18

Potentiation

Answer 18

drug increased effect with another drug

Question 19

Interaction

Answer 19

therapeutic or adverse effect on the body

Question 20

Physical dependence

Answer 20

physiological need for a drug

Question 21

Psychological Dependence

Answer 21

psychological craving for a drug

Question 22

Withdrawal Symptoms

Answer 22

when a drug is taken away a person experiences physical a psychological symptoms

Question 23

Drug Abuse

Answer 23

self administration of a drug in excessive quantities