Ch. 11 - Animal Forms and Function (A-E) Flashcards

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1
Q

Thermoregulation –

  • Ectotherms – obtain body heat from ____ (aka poikilotherms/cold-blooded)
  • – Invertebrates, amphibians, reptiles, fish
  • Endotherms – generate their own ____ (aka homeotherms/warm-blooded)
  • Regulatory mechanisms
    — Evaporation – body heat is removed as liquid evaporates (____)
    — Metabolism – muscle contraction and other metabolic activities generate heat
    — Surface Area – Vasodilation or vasoconstriction of extremity vessels results in heat retention or removal (blood
    flow to ears reduce body temp, countercurrent exchange keeps central parts of body warm)
A

____
environment
body heat
endergonic

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2
Q

Invertebrate Respiration:

Cnidaria: Protozoa and Hydra
o Direct with ____: large surface areas and every cell is either exposed to environment or close to it -> ____ of gases directly
with outside environment (e.g. flatworms). Small animals only.

A

environment

simple diffusion

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3
Q

Invertebrate Respiration:

Annelids:
o ____ secreted by earthworm provides moist surface for gaseous exchange by ____
o Circulatory system bring ____ to cells and waste products (CO2) back to skin for excretion

A

mucus
diffusion
O2

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4
Q

Invertebrate Respiration:

Arthropods (80% of all living species – insects, spiders, crustaceans (crabs), etc…
o Grasshopper
— Series of chitin-lined respiratory tubules called ____ open to surface in openings called ____ through with O2 enters, CO2 exits. No oxygen carrier is needed due to ____ and removal of respiratory gases between air and body cells; diffusion across moistened tracheal endings.

o Spider
— ____: stacks of flattened membranes enclosed in internal chamber

A

trachae
spiracles
direct distribution
book lungs

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5
Q

Invertebrate Respiration:

Fish
o Water enters mouth, passes over ____ (evaginated structures, create large ____, take O2 and deposit CO; can be external/unprotected or
internal/protected), exits through ____ (gill cover). ____ between opposing movements of water and underlying

A

gills
SA
operculum
countercurrent exchange

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6
Q

Plant Respiration
- Photosynthesis only takes place during the day.
o Photosynthesis produces glucose and gives off oxygen
o While respiration requires oxygen to degrade glucose

  • Plants undergo aerobic respiration similar to animals
    o Glucose -> 2ATP + 2 pyruvic acid
    o Gases diffuse into air space by entering and leaving through ____ of leaves or ____ in woody stems
    o Anaerobic respiration takes place in simple plants when molecular oxygen is lacking
A

stomata

lenticels

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7
Q

Gas exchange in human: CO2 is transported as HCO3- in the plasma (liquid portion of blood), catalyzed by ____ (____ ↔ ____ ↔ H+ + HCO3-) located in the RBC. Some CO2 mixes direct w/ plasma as gas, or binds with hemoglobin in RBCs

A

carbonic anhydrase
CO2 + H2O
H2CO3

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8
Q

Alveoli – where gas exchange between the circulatory system and the lungs occurs; ____ reduces the surface tension (prevents H2O from collapsing alveoli). There are two types of epithelial cells in human alveoli: type 1 (____) and type 2 (____)

A

surfactant
structural support
produce surfactant

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9
Q

Nose (filter, moisten, warms incoming air – mucus secreted by goblet cells traps large dust particles here), pharynx (____ – passageway for food and air; dust/mucus swept back here by ____ for disposal via spitting or swallowing), larynx (____- if ____ enters, cough reflex activates)

A

throat
cilia
voice box
non-gas

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10
Q

Trachea (____ covers the trachea during swallowing) – ringed cartilage (____) covered by ciliated mucus cells

A

epiglottis

C-shaped

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11
Q

Bronchi, Bronchioles: ____ bronchi, which enter the lungs and branch into narrower ____

Alveoli: Each bronchiole branches ends in these small sacs, which are surrounded by ____

A

two
bronchioles
blood-carrying capillaries

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12
Q

Diffusion between alveolar chambers and blood: Gas exchange across moist, sac membranes of ____. O2 diffuses through alveolar wall, through pulmonary capillary wall, into blood, and into red blood cells. (CO2 is ____)

A

alveoli

opposite

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13
Q

Bulk flow of O2: O2 transported through body within ____ containing red blood cells (RBCs)

Diffusion between blood and cells: Oxygen diffuses out of RBCs, across blood capillary walls, into ____, and across cell membranes (CO2 opposite)

A

hemoglobin

interstitial fluid

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14
Q

Bulk flow of CO2: CO2 mainly transported as ____ ions in plasma, liquid portion of blood. Produced by ____ in RBCs. CO2
can also directly mix with ____ (as CO2 gas), or bind ____ inside RBCs

A

HCO3-
carbonic anhydrase
plasma
hemoglobin

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15
Q

Bulk flow of air into and out of the lungs:
a. Inhalation – ____ (under lungs) and ____ (between ribs) contract/ flattens; increase in volume / decrease in ____ in lungs -> bulk flow of air into lungs.

b. Exhalation – ____ process; decrease in lung volume/ increase in air pressure -> air rushes out; diaphragm relaxes and ____

A

diaphragm
intercostal muscles
pressure

passive
expands

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16
Q

Bohr effect – hemoglobin O2 ____ decreases under conditions of low pH (high CO2 & [H+]) -> oxygen loads released by hemoglobin
 Decrease in ____ or ____ in pH will result in hemoglobin binding more O2
 Result of: CO2 + H2O -> H2CO3 -. H+ + HCO3-

A

binding affinity
CO2
increase

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17
Q

____ - Basically explains CO2’s dissociation curve. ↑ CO2 pressure = ↑ CO2 content in blood. But when hemoglobin is saturated by oxygen, its capacity to hold CO2
is ____. Essentially: we pick up CO2 in the tissues where it’s been generated, and get rid of it at the lungs and grab oxygen instead. Hemoglobin w/out oxygen acts as
____ by accepting H+ -> this reduced hemoglobin has higher capacity to form ____ rather than the oxygen carrying kind, explaining how the
Haldane effect occurs.

A

haldane effect
reduced
blood buffer
carbamino hemoglobin

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18
Q

*Oxygen diffuses from ____ into ____, CO2 diffuses from ____ into ____

A

alveolar air
blood
blood
lungs

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19
Q

Human respiration controlled by ____ – signals the diaphragm to ____

  • When ppCO2 increases, medulla stimulates ____ in rate of ventilation
  • The diaphragm is a ____ muscle innervated by the ____. It is also the only organ which only and all ____ have, and
    without which no mammals can live.
A

medulla oblongata
contract

increases
skeletal
phrenic nerve
mammals

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20
Q

Critical note: the majority of CO2 in the blood is transported in the form of the ____ (HCO3-). To a lesser extent, it can be transported bound to ____, and to an even lesser extent simply dissolved in the ____ (CO2 is ____ in blood than O2)

A

bicarbonate ion
hemoglobin/plasma proteins
plasma
significantly more

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21
Q

Bigger picture: tissues are high CO2 and high H+, and they’re not getting a lot of oxygen, we want to oxygenate them. So Hb (Hemoglobin) once near the tissues is exposed to the higher CO2/H+, and ____ to ____ form: this ____ form now releases its O2 to the tissues, and will also more preferably bind ____

A

changes structure
reduced
reduced
CO2

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22
Q

At the lungs, the CO2 wants out and is released. The H+ cxn is also lower due to bicarbonate being converted back into CO2 form for release. Now hemoglobin will change to its ____ that preferably binds ____, which it holds more tightly under these conditions.

A

non-reduced state

oxygen

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23
Q

Control of respiration: central chemoreceptors in the ____ monitors ____ in the cerebrospinal fluid (though not directly) and peripheral chemoreceptors in the carotid arties and aorta monitor aterial ____, ____, and ____. In an active body, there is increased CO2 production; it enters plasma is converted to HCO3- and H+, the blood pH drops -> respiratory rate ____. Oxygen and pH mainly monitored by the ____

A
medulla
[H+]
[H+]
[CO2]
[O2]
increases
peripheral chemoreceptors
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24
Q

As O2 pressure increases, O2 saturation of hemoglobin ____

  • This is ideal – in the lungs we are O2 rich and want to hang on to it, but in the tissues we are O2 poor (lower O2 pressure) so the hemoglobin will release the O2 to the tissues
A

increases

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25
Q

O2 saturation of hemoglobin also depends on CO2 pressure, pH, temp of blood

  • Oxygen dissociation curve shows the percentage of hemoglobin bound w/ O2 at various ____ of O2
- Curve is shifted right (i.e. oxygen is released easier, low O2 affinity) by an increase of CO2 pressure, H+ cxn,
or temp (and vice versa) (CADET face Right! – CO2, Acid, 2,3-DPG, Exercise, and Temperature)
  • Bohr effect – hemoglobin O2 binding affinity decreases under conditions of ____ (high CO2 & [H+]) -> oxygen loads ____ by
    hemoglobin because both O2 and H+ compete for binding at hemoglobin molecule
  • 2,3-DPG cxn increase also shifts ____: it’s produced in presence of ____ peripheral tissue O2 capacity
A
partial pressures
low pH
released
right
diminished
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26
Q

____ comes from inadequate ventilation: we don’t clear enough CO2 and it builds up, so via rxn above more H+ ends up getting formed -> pH ____ in tissues.

____ comes from breathing too rapidly: we are losing CO2 too quickly, via rxn above, H+ and HCO3- start combining to form more CO2, pH ____.

Metabolic acidosis and alkalosis are not due to breathing issues – you may alter breathing to compensate, but the cause is not ____.

A

respiratory acidosis
drops

respiratory alkalosis
rises

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27
Q

Chloride shift: carbonic anhydrase is in RBC’s so at the tissues to balance bicarbonate ions diffusing out of cells (because CO2 enters RBC, carbonic anhydrase converts, bicarbonate diffuses out to plasma) (vice versa at lungs), Cl- enters

  • CO2 carried in blood in three forms: in ____, as ____, and in ____ (combined w/ hemoglobin and other proteins). Majority carried as bicarbonate ion form.
A

physical solution
bicarbonate ion
carbamino compounds

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28
Q

Myoglobin of muscle has ____ curve (structure doesn’t do ____ cooperative binding, single subunit) saturates quickly and releases in very low oxygen “____” situations

A

hyperbolic
allosteric
emergency muscle

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29
Q

o Fetal hemoglobin curve is shifted ____ of adult – has higher ____ to grab O2 from maternal blood

A

left

binding affinity

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30
Q

Note: carbon monoxide has a ____hemoglobin than oxygen does! Have to administer pure O2 to ____ it once bound.

A

200x greater affinity

displace

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31
Q

Avian respiration is drastically ____ than human respiration. Due to the unique anatomy of birds, respiration is both ____ and ____. ____ allow birds to exchange gas during both inhalation and exhalation – oxygen rich incoming air is first stored in ____ before entering lungs for exhalation, so it is not mixed with the ____ air.

A
different
continuous
unidirectional
air sacs
air sacs
deoxygenated exhaled
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32
Q

In mammalian respiration there is ____ - we breathe in and out through the same tubing, inhibiting ____ during exhalation. Deoxygenated air is mixed with some ____ during inhalation, some of it is re-breathed. Much ____ than birds.

A

tidal breathing
gas exchange
fresh air
less efficient

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33
Q

CIRC. SYSTEM

Protozoans (unicellular animal-like [due to movement] protists)- movement of gas through ____ within cell

A

simple diffusion

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34
Q

CIRC SYSTEM

Cnidarians – body walls ____ cells thick, therefore all cells in ____ with either internal or external environment. Ex- hydra

A

2

direct contact

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35
Q

CIRC SYSTEM

Arthropods- most insects and molluscs

o ____- pump blood into internal cavity called ____ (cavities called ____), which bathe tissues in oxygen and nutrient containing fluid (____). This fluid returns to pumping mechanism (____) through holes called ____.

A
open circulatory system
hemocoel
sinuses
hemolymph
heart
ostia
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36
Q

CIRC SYSTEM

Annelids- earthworm

o ____- blood is confined to vessels.

  • Also seen in certain ____ (octopus and squid) and ____
  • Away from heart: aorta -> arteries -> ____ -> capillaries
  • Back to heart: capillaries -> ____ -> veins
A
closed circulatory system
mollusks
vertebrates
arterioles
venules
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37
Q

CIRC SYSTEM

Note: human and bird hearts have ____ , reptiles+amphibians ____, fish ____ (but crocs+gators have ____ chambers)

A

4 chambers
3
2
4

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38
Q

CIRC SYSTEM

 Human heart – (note: the ____ are the upper chambers of the heart) (animation of circuit flow)

o Right atrium – ____ blood enters via ____ and ____

o Right ventricle – blood is squeezed through right ____ into right ventricle which contracts and
pumps blood into ____ through the ____.
- When the ventricle contracts, AV valve closes to prevent ____
- When ventricle relaxes, ____ prevents backflow from pulmonary artery back into ventricles

A

atrium

deoxygenated
superior
inferior vena cava

AV/tricuspid valve
pulmonary artery
pulmonary semilunar valve

backflow
semilunar valve

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39
Q

CIRC SYSTEM
CONTINUING HUMAN HEART

Pulmonary circuit: blood pathway from ____ of heart to ____ to ____ of heart
- Blood flows from pulmonary artery -> ____ -> capillaries of the lungs -> collects in ____ -> ____
-> pulmonary veins -> left ____
o ____ is the circulation pathway through the body between left and right sides of heart
o Left atrium – after lungs the ____ blood enters left atrium via ____

A

right side
lungs
left side

arterioles
venules
veins
atrium

systemic circulation
oxygenated
pulmonary veins

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40
Q

CIRC SYSTEM
CONTINUING HUMAN HEART

Left ventricle – after going through left ____(aka mitral or bicuspid), blood from left ventricle goes to ____
through the ____ into rest of body:

  • Aorta -> arteries -> arterioles -> capillaries -> tissues get what they want -> venules -> veins -> ____ -> cycle repeats
  • As above: ____ prevents backlow into atrium, ____ prevents it into ventricle
    o So: ____ and ____prevent backflow
A

AV valve
aorta
aortic semilunar valve

superior and inferior vena cava

AV valves
aortic semilunar valve

right/left AV
pulmonary/aortic SL

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41
Q

CIRC SYSTEM

Cardiac Cycle – regulated (in terms of rate)by autorhythmic cells of the autonomic NS, but contractions are intiated
____ of the autonomic NS. Instead the heart contracts automatically:

A

independently

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42
Q

CIRC SYSTEM
CARDIAC CYCLE

SA (sinoatrial) node, or ____ (located in upper wall of right ____) is a group of specialized cardiac muscle
cells that initiates by contracting ____ atria and sending delayed impulse to stimulate ____.

  • Spreads contraction to surrounding cardiac muscles via ____ synapses made from ____
  • Pace of SA node is ____ than normal heartbeat but ____ innervates SA node
    (also increases digestive activity of intestines); ____ contractions
A

pacemaker
atrium
both
AV (atrioventricular) node

electrical
gap junctions

faster
parasympathetic vagus nerve
slows

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43
Q

CIRC SYSTEM
CARDIAC CYCLE

o AV node – located in lower wall of the right ____; sends impulse through ____ ->
passes between both ventricles -> branches into ventricles via the ____ which results in ____

A

atrium/interatrial septa
bundle of His
purkinje fibers
contraction

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44
Q

CIRC SYSTEM
CARDIAC CYCLE

When the ventricles contract (____ phase), blood is forced through pulmonary arteries and aorta
– When they relax (____ phase), backflow into ventricles causes ____ to close.

  • ____: Heart Rate * Stroke Volume. The volume of blood pumped by the ventricle (per min)
  • ____: number of beats per minute
- \_\_\_\_ = EDV - ESV. Volume of blood pumped out of the heart with each beat. Formula subtracts
the End-systolic Volume (blood in the ventricle at the end of the contraction/systole) from the End-
diastolic Volume (volume of blood in the ventricle just before contraction)
A

systole

diastole
semilunar valve

cardiac outpout

heart rate

stroke volume

45
Q

CIRC SYSTEM

Heart contraction: heart is a large muscle, but unlike ____, not anchored to ____. Its fibers form a net and the net contracts upon itself, which squeezes blood into arteries.

A

skeletal

bone

46
Q

CIRC SYSTEM

____: occurs when ventricles contract. ____: occurs during relaxation of the entire heart and then contraction of the ____.

A

systole

diastole

47
Q

CIRC SYSTEM

____ from heart contracting causes blood to move through arteries. Blood pressure drops as it reaches the ____, and reaches near zero in the ____. Blood continues to move through veins because of pumping of the heart assisted by movements of adjacent ____, expansion of atria each time heart beats, and falling pressure in chest when a person breathes.____ in the veins prevent backflow.

A
hydrostatic pressure
capillaries
venules
skeletal muscles
valves
48
Q

CIRC SYSTEM

Blood Vessels: (arteries, veins, and capillaries)
o Arteries: thick-walled, muscular, ____, pump oxygenated away (except for pulmonary arteries that transport deoxygenated blood from heart
to lungs). Wrapped in ____ typically innervated by ____
o Arterioles: Very small, wrapped in ____, constrict/dilate to ____ and reroute blood – major determinant of ____
o Capillaries: have smallest diameter- single layer of ____ across which gases, nutrients, enzymes, hormones, and waste ____
- 4 methods for material to cross capillary wall: ____, diffusion through ____, movement through pores in the cells (____), movement through space between the cells
o Venules: Small blood vessels that lead back to veins; very thin and ____; drain blood from capillary bed -> venules combine -> veins
o Veins: Larger veins often have ____ to aid in transport of deoxygenated blood back to heart due to fighting gravity (except for pulmonary
veins and umbilical vein that carry oxygenated blood)

A

elastic
smooth muscle
sympathetic NS

smooth muscle
regulated BP
pressure

endothelial cells
diffuse
pinocytosis
capillary cell membrane
fenestrations

porous

valves

49
Q

CIRC SYSTEM

Lymph Vessels
o Lymphatic system is an open ____ system- transports excess ____ through the contraction of adjacent
muscles & some walls of larger lymph vessels have ____
o Proteins & large particles that can’t be taken up by ____ removed to lymph; also monitors blood for infxn
o Valves prevent backflow- fluid returns to ____ through two ducts located in ____ (thoracic&right lymphatic duct)
o Lymph nodes contain ____ (leukocytes) that filter the lymph and serve as immune response centers

A

secondary circulatory
interstitial fluid (lymph)
smooth muscle

capillaries
blood circulatory system
shoulder region

phagocytes

50
Q

CIRC SYSTEM

Blood – 4-6 liters in the human body; is a connective tissue
o 55% liquid (____) and 45% cellular components – plasma is an aqueous mixture of nutrients, salts, gases, wastes, hormones, and blood proteins (immunoglobulins, albumin, fibrinogen, clotting factors)

  • Cellular components
    • Erythrocytes (RBCs) – transport O2 (up to 4) on hemoglobin, catalyze conversion of CO2 and H2O to H2CO3 – ____ to maximize hemoglobin content
    • Leukocytes (WBCs) – larger and phagocytize foreign matter and organisms
  • – ____ – the process by which WBCs become part of the interstitial fluid (slip through the endothelial lining)
  • -Platelets/thrombocytes- cell fragments involved in blood clotting – lack nuclei; stick to damaged epithelium; attract more
  • – Convert ____ (inactive) to ____ (active)
  • – Derived from ____
A

plasma

lack nucleus/organelles

diapedesis

fibrinogen
fibrin
megakaryocytes

51
Q

CIRC SYSTEM

Process of blood clotting

  1. Platelets contact exposed collagen of damaged vessel and cause neighboring platelets to form ____
  2. Both the platelets and damaged tissue release clotting factor, ____
  3. Thromboplastin converts inactive plasma protein ____ to ____ (active)
  4. Thrombin converts ____ into ____
  5. ____ threads coat damaged area and trap blood cells to form a clot
A

platelet plug
thromboplastin
prothombrin
thrombin

fibrinogen
fibrin

fibrin

52
Q

CIRC SYSTEM

Myoglobin curve = ____, Hemoglobin curve = ____. Myoglobin has higher affinity for ____ than hemoglobin. Myoglobin has no change in O2 binding over a ____.

A

hyperbolic
sigmoidal
O2
pH range

53
Q

CIRC SYSTEM

Hemoglobin – binds CO w/ much ____ than myoglobin (it also has 4 subunits vs 1)
Myoglobin = single chain/protein subunit, stores O2 in muscle

A

greater affinity

54
Q

CIRC SYSTEM

Fetal circulation: oxygenated, nutrient-rich blood from placenta carried to fetus via ____ -> half enters ____ (allows blood to bypass the liver) -> carried to inferior vena cava -> RA -> RV -> ____ (conducts some blood from the pulmonary artery to the aorta [bypassing the lungs/fetal pulmonary circulation]) -> aorta.

Other half enters liver/portal vein -> RA -> ____ (allows blood to bypass pulmonary circulation by entering the left atria directly from the right atria since there is no gas exchange in fetal lung) -> LA -> LV -> aorta.

A

umbilical vein
ductus venosus
ductus arteriosus

foramen ovale

55
Q

CIRC SYSTEM

____ = SV (stroke volume) X HR (heart rate)

  • Stroke volume = volume of blood discharged from the ____ with each contraction.
  • Cardiac output = volume discharged from ventricle each minute.
  • Stroke volume = ____ – ____.
A

cardiac output (CO)
ventricles
end systolic volume
end diastolic volume

56
Q

CIRC SYSTEM

____ = another blood antigen; mother might attack Rh+ in 2nd fetus (____) (first child is fine but during 1st childbirth blood exposure -> antibodies to Rh attack 2nd)

A

Rh factor

erythblastosis fetalis

57
Q

CIRC SYSTEM

Double capillary beds (portal system) occur in ____, capillaries that surround ____, small intestine, liver, and ____ and anterior pituitary gland. Capillary bed pools into another capillary bed (capillary bed 1 -> drains into portal vein -> capillary bed 2 -> drains into vein that returns blood to heart) w/out first going to heart (transport products in ____ without spreading to rest of body)

A

glomerulus
loop of henle
hypothalamus
high concentration

58
Q

CIRC SYSTEM

Phosphate buffer system – maintains pH of ____ of all cells; H2PO4- and HPO42- act as acid & base (____)

A

internal fluids

amphoteric

59
Q

EXCRE SYSTEM

  1. Osmoregulation:
    a. Marine fish: body is hypotonic to environment -> water is constantly ____ by osmosis, constant ____, rarely ____, and secrete accumulated ____ through gills.

b. Fresh water fish: body is hypertonic to environment; water moves in => rarely ____, constantly ____, and
absorb ____ through gills.

A

lost
drinking
urinate
salt

drink
urinate
salt

60
Q

EXC SYSTEM

Protozoans and Cnidarians – all ____ in contact with external, aqueous environment

  • Water soluble wastes (ammonia, CO2) exit by ____
  • Protists such as Paramecium and aoebas – possesses ____ for XS H2O excretion by ____ transport
A

cells
simple diffusion
contractile vacuoles
active transport

61
Q

EXC SYSTEM

Annelids – CO2 excretion directly through ____
- ____ (metanephridia) occur in pairs within each segment of annelids (earthworms). Interstitial fluids enter a nephridium through ciliated opening
____ and concentrate through ____ due to selective secretion into surrounding coelomic fluid. Blood that surrounds tubule reabsorb.
Water, salts, urea are excreted through ____.

A
moist skin
nephridia
nephrostome
collecting tubule
excretory pore
62
Q

EXC SYSTEM

Platyhelminthes – flame cells (____) – distributed along branched tube system that permeates the flatworm
- Body fluids filtered across flame cells, whose cilia move fluids through tube system; wastes exit through pores of tube

A

protonephridia

63
Q

EXC SYSTEM

Arthropods – CO2 released from tissues -> ____ (which are continue with ext. air thru ____)
- ____: occurs in arthropods (terrestrial insects). Tubes attached to mid digestive tract (midgut) collect
body fluids from ____ that bath the cells; fluids are deposited into midgut. Fluids include ____ (in form of uric acid crystals; H2O, salt retained. As fluid passes through hindgut, retained materials pass out of walls and wastes continue down the tract for excretion through ____.

A
tracheae
spiracles
malphigian tubules
hemolymph
nitrogenous wastes
anus
64
Q

EXC SYSTEM

Excretion in Humans – lungs, liver, skin, and kidney

  • Lungs – ____ and ____ diffuse from blood and are continually exhaled
  • Liver – processes ____, blood pigment wastes, other chemicals, ____ prod.
  • Skin – sweat glands in skin excrete water and dissolved salts/regulate body temp (sweat gland fxn decreases as we age)
  • Kidney – Three regions: 1) ____, 2) ____, and 3) ____ which drains to ____. Each has many nephrons. Kidneys -> ureter -> ____ ->
    urethra. Functions to excrete waste, maintain ____ of body fluid volume and solute composition, and help control ____
A

CO2
H2O(g)

nitrogenous wastes
UREA

outer cortex
inner medulla
renal pelvis
ureter
bladder
homeostasis
plasma pH
65
Q

EXC SYSTEM

Nephrons – composed of ____ and ____; reabsorbs nutrients, salts, and water

A

renal corpuscle

renal tubule

66
Q

EXC SYSTEM

NEPHRONS

Renal corpuscle – glomerulus (sieve) surrounded by ____; ____ arteriole=into glomerulus; ____ arteriole=out of glomerulus
o After efferent arteriole passes back out of the glomerulus is just webs around the entire ____ (see above) as the peritubular capillaries (surround PCT and DCT; reabsorb stuff) and vena cava (surround LOH in medulla, maintain cxn gradient) before dumping back in to the ____ of renal vein. Meanwhile, Bowman’s capsule leads to…

A

bowman’s capsule
afferent
efferent

nephron structure
renal branch

67
Q

EXC SYSTEM

NEPHRONS
RENAL TUBULE
(1) o ____ – active ____ of glucose, ions, amino acids begins (water follows ->
cortex not ____)
– Drugs, toxins, etc secreted into ____; H+ ions secreted in as well via antiport with Na+

A

proximal convoluted tubule
reabsorption
salty
filtrate

68
Q

EXC SYSTEM

NEPHRONS
RENAL TUBULE

(2) Loop of Henle (____)
- DESCENDING – only permeable to ____ (but this ____ is picked up by vasa recta -> medulla stays
____)
- ASCENDING makes renal medulla ____–actively pumps out Na+,K+,Cl- ; impermeable to ____!
- This process allows reabsorption of 99% of filtrate -> conc. ____

A

majority of nephron
water
water
salty

salty
water
urine

69
Q

EXC SYSTEM

NEPHRONS
RENAL TUBULE

(3) Distal convoluted tubule – more ____ of glucose, ions, water, etc (cortex not ____). Filtrate: Na+ and Ca2+ get ____ into body, K+/H+/HCO3- ____ via tubule. Distal tubule empties to…

A

reabsorption
salty
reabsorbed
secreted out

70
Q

EXC SYSTEM

NEPHRONS
RENAL TUBULE

(4) Collecting duct – collects remaining filtrate. Is ordinarily ____ to water unless ____ acts on it
- Descends to medulla (salty part), where ____ hormones (____) can make MORE
____ leave from urine by increasing permeability of collecting duct -> urine even more
____. 1 CD shared by many ____

  • Also, ____ acts on DCT and CD: increase Na+ resorbtion, K+ secretion -> water passively
    follows Na+
A

impermeable
ADH

antidiuretic
ADH/vasopressin
water
concentration
nephrons

aldosterone

71
Q

EXC SYSTEM

URINE FORMATION

(1) Filtration – The fluid that goes through ____ (afferent arteriole => glomerulus => efferent) to the rest of the nephron is called ____; particles that are too large to filter through (blood and albumin) remain in ____; passive process; driven by ____ of blood. So Glomerulus -> filtrate pushed into ____.

A
glomerulus
filtrate
circulatory system
hydrostatic pressure of blood
bowman's capsule
72
Q

EXC SYSTEM

URINE FORMATION

(2) Secretion – substances such as acids, bases, and ions (K+) are secreted by both ____; secreted from ____

A

passive/active transport

peritubular capillaries

73
Q

EXC SYSTEM

URINE FORMATION

(3) Reabsorption – glucose, salts, AA, and water are ____ from filtrate & return to blood; takes place namely in ____

A

reabsorbed

proximal convoluted tubule (active)

74
Q

EXC SYSTEM

URINE FORMATION

(4) Concentration – when dehydrated volume of fluid in bloodstream is low so you need to make small amounts of concentrated urine => ____ prevents water loss by making distal tubule ____ to water /// when Blood Pressure is low => ____ increases reabsorption of Na+ by ____ which increases ____ (serum [Na+] increases BP)

A

ADH
permeable

aldosterone
distal nephron
water retention

75
Q

EXC SYSTEM

filtration occurs in ____ -> reabsorption/secretion mostly in ____ -> filtrate becomes more cxn as it moves ____ loop of Henle (water passive out of tube) -> more dilute as it moves up ____ (passive and active transport of salts out, but not water) -> DCT dumps into ____ -> filtrate more cxn again as it descends collecting duct (because surrounding medulla is ____, water leaves) -> CD leads to ____ -> empties into ____ -> drains to ureter. Keep in mind ____ means back into the body

A
renal corpuscle
proximal tubule
down
loop
collecting duct
salty
renal calyx
renal pelvis
reabsorb
76
Q

EXC SYSTEM

Juxtaglomerular Apparatus: monitors ____ pressure in DT via ____ -> secrete ____ -> angiotensin cascade -> tells ____ to make aldost

A

filtrate pressure
granular cells
renin
adrenal cortex

77
Q

EXC SYSTEM

** Selective permeability of the tubules establishes an ____ in the surrounding ____

A

osmolarity gradient

interstitial fluid

78
Q

EXC SYSTEM

*** Urine is ____ to the blood and contains a ____ urea and solute concentration.

A

hypertonic

high

79
Q

EXC SYSTEM

Osmolarity Gradient – created by exiting / entering of solutes; ____ from cortex to medulla

A

increases

80
Q

EXC SYSTEM

____ - descending loop permeable to water & ascending is permeable to salts / ions; this makes the medulla ____ and ____ water reabsorption

A

counter current multiplier
very salty
facilitates

81
Q

EXC SYSTEM

Nitrogen as a waste product: Aquatic animals excrete ____ or ____ directly into ____ , mammals convert NH3 to ____ ,
Birds/insects/reptiles convert urea to ____ (____ in water, water conservation, excreted as ____ )

A
NH3
NH4
water
urea
uric acid
insoluble
solid
82
Q

EXC SYSTEM

____ = special sac in bird egg that keeps N waste away from embryo

A

allantois

83
Q

EXC SYSTEM

Excretion in Plants – excess CO2, waste O2, and H2O (g), leave by diffusion through ____ and ____ -> This process is called ____

A

stomata
lenticels
transpiration

84
Q

DIG SYSTEM

UNICELLULAR
- Amoeba
o Food capture: ____ -> food ____
o Food ____ fuse with ____

  • Paramecium
    o ____ sweep food into ____
    o Food vacuole forms and moves toward anterior end of cell
A

phagocytosis
vacuole
vacuole
lysosome

cilia
cytopharynx

85
Q

DIG SYSTEM

INVERTEBRATES

  • ____ – cutting and grinding in mouth; churning in digestive tract
  • ____ – enzymatic hydrolysis -> smaller nutrients -> pass through semi-permeable membrane of gut cells to be further metabolized

-Cnidarians
o Hydra- ____ and ____ digestion

-Annelids
o Earthworms – \_\_\_\_ digestive tract
-- \_\_\_\_ – food storage
-- \_\_\_\_ – grind food
-- Intestine – contains \_\_\_\_ to increase surface area for absorption
  • Arthropods
    o Also have jaws for chewing and ____
A

physical breakdown
chemical breakdown

intracellular
extracellular

one-way
crop
gizzard
typholosole

salivary glands

86
Q

DIG SYSTEM

Digestion in Humans
Four groups of molecules encountered
1. \_\_\_\_ -> glucose
2. \_\_\_\_ -> amino acids
3. \_\_\_\_ -> fatty acids
4. \_\_\_\_ -> nucleotides
A

starches
proteins
fats
nucleic acids

87
Q

DIG SYSTEM

  1. Mouth - ____ breaks down (starch -> maltose), chewing creates ____ which is swallowed
A

salivary a-amylase

bolus

88
Q

DIG SYSTEM

  1. Pharynx (____) – this is where food and air passages ____; the ____, flap of tissue, blocks trachea so only solid and liquid enter…
A

throat
cross
epiglottis

89
Q

DIG SYSTEM

  1. Esophagus – tube leading to stomach, food travels by contractions (____),
A

peristalsis

90
Q

DIG SYSTEM

  1. Stomach – secretes ____ (digestive enzymes and HCl) – food enters stomach through ____. The
    stomach contains ____ glands (local secretion by way of duct) within gastric pits (indentations in stomach that denote entrance to the
    gastric glands, which contain ____, parietal cells, and mucous cells (secrete mucus to ____)
A
gastric juice
lower esophageal/cardiac sphincter
exocrine
secreting chief cells
prevent backwash
91
Q

DIG SYSTEM

STOMACH

a. Storage – ____ folds allow 2-4 liters of storage

A

accordian-like

92
Q

DIG SYSTEM

STOMACH

b. Mixing – mixes food w/ H2O and gastric juice -> ____ (creamy medium)
c. Physical breakdown – ____ break food; ____ denatures proteins & kills bacteria

A

chyme
muscles
HCl

93
Q

DIG SYSTEM

STOMACH

d. Chemical breakdown – ____ (secreted by ____) digests proteins; (pepsinogen activated by ____, which is secreted by
____)
i. ____ – caused by failure of mucosal lining to protect stomach
– Ulcers can be caused by excess stomach acid or ____ as well

A

pepsin
chief cells

HCl
parietal cells

peptic ulcers
H.pylori

94
Q

DIG SYSTEM

STOMACH

e. Controlled release – chyme -> small intestine; controlled by ____

A

pyloric sphincter

95
Q

DIG SYSTEM

STOMACH

f. Stomach cells
i. ____ – secrete mucus that lubricates & protects stomach’s epithelial lining from acid environment
ii. ____ – ex.gl. secrete pepsinogen (zymoegn precursor to ____).
– Pepsinogen activated to pepsin by ____ in stomach; once active begins ____
iii. ____ – Secrete HCl; intrinsic factor (B-12 absorption)
iv. ____ – secrete gastrin, a large peptide hormone which is absorbed into blood -> stims ____ to secrete HCl
v. Affected by: ____ increases secretion of all cell types, ____ and ____ increase HCl secretion

A
mucous cells
chief cells
pepsin
low pH
protein digestion
parietal cells
g cells
parietal cell
a-chol
gastrin
histamine
96
Q

DIG SYSTEM

Small intestine – food goes from stomach to small intestine through the ____ - first 25cm (____), continues breakdown
of starches and proteins as well as remaining food types (fats and nucleotides); ____ between it and large intestine. Structure is duodenum (most ____), jejunum, then ileum (jej and il mostly ____). 90% of digestion and absorption occurs in ____; completes.

A

pyloric sphincter
duodenum

ileocecal valve
digestion
absorption
small intestine

97
Q

DIG SYSTEM

SMALL INTESTINE

a. Structure – Wall has finger-like projections called ____ that increase the surface area for greater digestion/absorption. Each villi has a ____ (lymph vessel surrounded by capillary network; both fxn for nutrient absorption). Villi have ____, more SA.
i. ____ secrete mucus to lubricate and protect from mech/chem damage
ii. Duodenum has a ph ~6 mainly due to ____ secreted by ____

A

villi
lacteal
microvilli

goblet cells
bicarbonate ions
pancreas

98
Q

DIG SYSTEM

SMALL INTESTINE

b. Enzyme origin
i. Small intestine – ____ enzymes: proteases, maltase and lactase, phosphatases/nucleosidases (nucleotides); lipase

A

proteolytic

99
Q

DIG SYSTEM

SMALL INTESTINE

c. Pancreas – secretes ____; also acts as ____ gland releasing major enzymes from ____ via pancreatic duct -> duodenum
- Trypsin & chymotrypsin (proteases), lipase, pancreatic amylase, deoxy&ribonucleases
- All exist as ____ first. Trypsin gets activated, then activates the other enzymes - These enzymes in alkaline solution (____ -> ____)

A
bicarbonate
exocrine
acinar cells
zymogens/proenzymes (inactive)
pancreatic duct
duodenum
100
Q

DIG SYSTEM

SMALL INTESTINE

d. Liver – produces ____ (no ____, emulsifies fats) stored in ____, flows thru bile duct which merges with ____

A

bile
enzymes
gall bladder
pancreatic duct

101
Q

DIG SYSTEM

SMALL INTESTINE

e. Remainder of small intestine (6m) absorbs breakdown products (____ and ____)
i. Amino acids and sugars -> ____ ; fatty acids and glycerol -> ____. System

A

villi
microvilli
capillaries
lymph

102
Q

DIG SYSTEM

SMALL INTESTINE

f. Chyme moves through intestines via ____ as well. ____ (2nd type of intestinal motion) mixes chime w/ dig. juices

A

peristalsis

segmentation

103
Q

DIG SYSTEM

  1. Large intestine (colon) – reabsorption of water and salts to form ____; 1.5m long
    a. Feces stored at end of L.I. in the ____ -> excreted through ____
    b. At beginning is ____, which in herbivores is large ____ (cellulose ____) with the help of bacteria
    c. Bacteria (e.g. E.Coli) a ____ in large intestine = main source of ____ (also Vitamin B)
A
feces
rectum
anus
appendix
cecum
digestion
symbiont
vitamin K
104
Q

DIG SYSTEM

ECL cells are neuroendocrine cells in the digestive tract; ____ stimulates them to release ____ which in turn stimulates parietal cells to produce ____

A

gastrin
histamine
gastric acid

105
Q

DIG SYSTEM

Hormones involved in the digestive process

  1. Gastrin – produced by ____ when food reaches or upon sensing of food; more above
  2. Secretin – produced by cells lining ____ when food enters; stimulates pancreas to produce ____ (____ the chime)
  3. Cholecystokinin – produced by ____ in response to ____; stimulates gallbladder to release ____ and ____ to release its enzymes
  4. Gastric Inhibitory Peptide – produced in response to ____ in duodenum; ____ of stomach motor activity
A

stomach lining

duodenum
bicarbonate
neutralizes

S.I.
fats
bile
pancreas

fat/protein digestates
mild decrease

106
Q

DIG SYSTEM

Digestion in plants and fungi
Plants have no ____, but intracellular processes similar to ____ do occur

Intracellular digestion – store primarily ____ in seeds, stems, and roots; when nutrients are required, polymers are broken down (into glucose, fatty acid, glycerol, and amino acids) by enzymatic ____

Extracellular digestion – several plants must obtain nutrient from environment

  • Fungi – ____ of bread mold, secrete enzymes into bread, producing simple digestive products which are then absorbed by ____ into rhizoid
  • Venus flytrap – enzymes digest trapped fly (serves as ____ source); *still ____
A

digestive system
animals

starch
hydrolysis

rhizoids
diffusion
nitrate
autotrophic

107
Q

DIG SYSTEM

LIVER FXNS

  • Blood ____
  • Blood Filtration – ____ phagocytize bacteria picked up in intestines
  • Carbohydrate Metabolism – Liver maintains normal blood glucose levels via ____ (production of glycogen and glucose from
    noncarb precursors), ____, and storage of glycogen
    – All carbs absorbed into blood are carried by ____ to the liver. Absorbed gal and fru converted to glu, then stored as ____.
A

storage
kupfer cells

gluconeogenesis
glycogenesis
portal vein
glycogen

108
Q

DIG SYSTEM

LIVER FXNS

  • Protein metabolism – Liver ____ AA’s, forms ____ from ammonia in blood, synths plasma proteins, synths nonessential AAs
    • Detoxification – Detox’d chemicals, excreted by liver as part of ____ (or polarized to be excreted by ____)
  • Erythrocyte destruction – ____ destroy irregular erythrocytes (but most are destroyed by ____)
  • Vitamin Storage – Stores ____. Also stores ____ by combining it with apoferritin -> ____
A

deaminates
urea
bile
kidneys

kupfer cells
spleen

vita A, D, B12
iron
ferritin

109
Q

DIG SYSTEM

LIVER FXNS

  • All carbs absorbed into blood are carried by ____ to the liver
  • Glycogenesis (formation of ____) and ____ (if blood glucose levels ____ -> glycogen broken down to glu for release)
  • When liver mobilizes fat or protein for energy, blood acidity ____ (____ are produced -> ketosis/acidosis results)
  • Blood supply: hepatic portal vein supplies blood as does ____ (oxygenates liver); blood leaves via ____ -> ____
  • Digestive (produces ____); Transport (synthesizes ____ proteins important in ____)
A

portal vein

glycogen
glycogenolysis
decrease

increases
ketone bodies

hepatic artery
hepatic vein
vena cava

bile
blood plasma
clotting