Ch 10 Flashcards
What HPV causes Verruca Vulgaris
2
4
6
40
What is the most common color of V V oral lesions
White
What is the differential for Squamous papilloma
Verruca Vulgaris
Condyloma Acuminatum
Verruciform Xanthoma
What HPV is squamous papilloma caused by
6
11
What is the most common site for V V
hands
What is another name for condyloma cuminatum
venereal wart (STD)
What HPV cause Condyloma cuminatum
2
6 and 11 most common
16, 18, 31 high risk
53
54
What is the average size of condyloma acuminatum
1-1.5cm twice as large as the others
What two HPV represent increased risk for squamous cell carcinoma in anogenital area
16
18
what is another name for multifocal epithelial hyperplasia
Heck’s disease
What HPV cause multifocal epithelial hyperplasia
13
32
What is the Tx for multifocal epithelial hyperplasia
Nothing, they spontaneously regress.
What virus type is molluscum contagiousum caused by
DNA poxvirus
What is a histopathology sign of molluscum contagiousum
molluscum bodies/ Henderson-Paterson bodies
What are xanthoma cells
lipid-laden histiocytes
What for of seborrheic keratosis occurs in aa
Papulosa nigra
What is the sudden appearance of numerous seborrheic keratoses called
Leser-Trelat sign
Actinic Keratosis is caused by
Cumulative UV radiation
Metastatic spread is largely via
Lymphatics
What is TNM
o T = size of primary local tumor in centimeters
o N = Involvement of local lymph nodes
o M = Distant metastasis
What is field cancerization
tendency towards development of multiple mucosal cancers
What is the lip version of actinic keratosis called
Actinic cheilosis
When should actinic cheilosis should be biopsied
Induration
thickening
Ulceration
What syndrome pts have an increased risk for SCCA
Plummer-Vinson
What are the most common intraoral SCCA sites in order
1) Tongue: posterior lateral and ventral
2) FOM
3) Soft palate
4) Gingiva
Lymphatic nodes that have been infected by SCCA present as
Firm to stony hare
Painless
Enlarged
Fixed
What are the most common sites for verrucous carcinoma
Mandibular vestibule
Gingiva
Nashopharyngeal carcinoma is associated with what virus
EBV
Consumption of what might lead to nasopharyngeal carcinoma
salt fish with N-nitrosamines
What cancer is the most common
Basal cell carcinoma
What is the most common form of basal cell carcinoma
nodular; noduloulcerative
What does basal cell carcinoma look like
papule with telangiectatic blood vessels, umbilicated with rolled borders.
What is the ABCDE of melanona
Asymmetry; one half is different from the other Border; Irregular, notched or blurry Color; more than one Diameter; larger than 6mm Evolving lesions
What skin cancer accounts for the most deaths
Melanoma; third most common skin cancer but accounts for the most deaths.
What two directional patterns does melanoma present
Radial; horizontal spread through basal layer–> flat lesion
followed by
Vertical; invasion of underlying connective tissue–> Tumor
How big of a surgical excision margin is used for melanoma
3-5 cm
What is the BANS of melanoma
Back; Interscapular area
Arm; posterior upper
Neck; Posterior and lateral
Scalp
What is the prognosis for oral melanoma
extremely poor
What are the most common sites for squamous papilloma
Tongue
lips
soft palate
How does squamous papilloma present clinically
Painless
usually pedunculated
Exophytic
white, red or mucosal color
Where is the most common site for verruciform xanthoma
gingiva
The blue color of a blue nevus is due to
Tyndall effect
What is the definition of leukoplakia
an intraoral white plaque that does not rub off and cannot be identified as any other well known entity.
What are some white lesions that can be scraped off
Materia alba white coated tongue burn Pseudomembranous candidiasis sloughing from toothpaste
What is the etiology of leukoplakia
tobacco alcohol sanguinaria UV rad microorganisms trauma
Where are 70% of leukoplakia lesions found
lip vermilion
buccal mucosa
gingiva
Leukoplakia with 90% dysplasia or carcinoma is found in
Lip vermillion
lateral/ventral tongue
FOM
lesions that demonstrate scattered red patches are termed
erythroplakia
Red and white intermixed lesions are termed
erythroleukoplakia
What does PVL stand for
Proliferative verrucous leukoplakia
Does PVL have an association with tobacco use
No
What % of leukoplakias become SCCA and within what time frame
5% within 2-4 yrs
What factors increase the risk for cancer in leukoplakia
persistent over several years
female ptn
Non-smoker
FOM or ventral tongue lesions
Smokeless tobacco keratosis presents with NO
Induration
ulceration
Pain
What disease is linked to chronic placement of betel quid or paan
Oral submucous fibrosis
What is quid
Areca nut slaked lime betel leaf tobacco sweteners
What is the CC of oral sub mucous fibrosis
trismus
mucosal pain from eating spicy foods
What are 12 possible contributors to SCCA
o Tobacco o Betel Quid o Alcohol o Phenolic agents o Radiation o Iron deficiency o Vitamin-A deficiency o Syphilis o Oncogenic viruses o Immunosuppression o Oncogenes o Tumor suppressor genes
What is the relative risk fro oral SCCA for a smoker
2ppd= 5 4ppd= 17
Wood industry workers are exposed to —- leading to SCCA
phenoxyacetic acids
Vitamin A deficiency leads to excessive prod of
keratinization
What HPV viruses are considered oncogenic
16
18
31
33
Distant metastasis is most commonly found in
Lungs
Liver
Bones
Meaning of X following TNM
No available information
Meaning of O following TNM
No evidence of distant metastasis
What carcinoma has a “deceptively benign” microscopic appearance
Verrucous carcinoma
Melanoma invasions > ___ mm in oral mucosa has poor diagnosis
0.5 mm
What are the histologic categories for leukoplakia
Mild 1/2
Carcinoma in situ
