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Pathology > Ch 10 > Flashcards

Ch 10 Flashcards

1
Q

What HPV causes Verruca Vulgaris

A

2
4
6
40

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2
Q

What is the most common color of V V oral lesions

A

White

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3
Q

What is the differential for Squamous papilloma

A

Verruca Vulgaris
Condyloma Acuminatum
Verruciform Xanthoma

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4
Q

What HPV is squamous papilloma caused by

A

6

11

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5
Q

What is the most common site for V V

A

hands

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6
Q

What is another name for condyloma cuminatum

A

venereal wart (STD)

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7
Q

What HPV cause Condyloma cuminatum

A

2
6 and 11 most common

16, 18, 31 high risk
53
54

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8
Q

What is the average size of condyloma acuminatum

A

1-1.5cm twice as large as the others

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9
Q

What two HPV represent increased risk for squamous cell carcinoma in anogenital area

A

16

18

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10
Q

what is another name for multifocal epithelial hyperplasia

A

Heck’s disease

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11
Q

What HPV cause multifocal epithelial hyperplasia

A

13

32

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12
Q

What is the Tx for multifocal epithelial hyperplasia

A

Nothing, they spontaneously regress.

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13
Q

What virus type is molluscum contagiousum caused by

A

DNA poxvirus

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14
Q

What is a histopathology sign of molluscum contagiousum

A

molluscum bodies/ Henderson-Paterson bodies

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15
Q

What are xanthoma cells

A

lipid-laden histiocytes

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16
Q

What for of seborrheic keratosis occurs in aa

A

Papulosa nigra

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17
Q

What is the sudden appearance of numerous seborrheic keratoses called

A

Leser-Trelat sign

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18
Q

Actinic Keratosis is caused by

A

Cumulative UV radiation

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19
Q

Metastatic spread is largely via

A

Lymphatics

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20
Q

What is TNM

A

o T = size of primary local tumor in centimeters
o N = Involvement of local lymph nodes
o M = Distant metastasis

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21
Q

What is field cancerization

A

tendency towards development of multiple mucosal cancers

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22
Q

What is the lip version of actinic keratosis called

A

Actinic cheilosis

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23
Q

When should actinic cheilosis should be biopsied

A

Induration
thickening
Ulceration

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24
Q

What syndrome pts have an increased risk for SCCA

A

Plummer-Vinson

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25
Q

What are the most common intraoral SCCA sites in order

A

1) Tongue: posterior lateral and ventral
2) FOM
3) Soft palate
4) Gingiva

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26
Q

Lymphatic nodes that have been infected by SCCA present as

A

Firm to stony hare
Painless
Enlarged
Fixed

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27
Q

What are the most common sites for verrucous carcinoma

A

Mandibular vestibule

Gingiva

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28
Q

Nashopharyngeal carcinoma is associated with what virus

A

EBV

29
Q

Consumption of what might lead to nasopharyngeal carcinoma

A

salt fish with N-nitrosamines

30
Q

What cancer is the most common

A

Basal cell carcinoma

31
Q

What is the most common form of basal cell carcinoma

A

nodular; noduloulcerative

32
Q

What does basal cell carcinoma look like

A

papule with telangiectatic blood vessels, umbilicated with rolled borders.

33
Q

What is the ABCDE of melanona

A 
Asymmetry; one half is different from the other
Border; Irregular, notched or blurry
Color; more than one 
Diameter; larger than 6mm
Evolving lesions
34
Q

What skin cancer accounts for the most deaths

A

Melanoma; third most common skin cancer but accounts for the most deaths.

35
Q

What two directional patterns does melanoma present

A

Radial; horizontal spread through basal layer–> flat lesion
followed by
Vertical; invasion of underlying connective tissue–> Tumor

36
Q

How big of a surgical excision margin is used for melanoma

A

3-5 cm

37
Q

What is the BANS of melanoma

A

Back; Interscapular area
Arm; posterior upper
Neck; Posterior and lateral
Scalp

38
Q

What is the prognosis for oral melanoma

A

extremely poor

39
Q

What are the most common sites for squamous papilloma

A

Tongue
lips
soft palate

40
Q

How does squamous papilloma present clinically

A

Painless
usually pedunculated
Exophytic
white, red or mucosal color

41
Q

Where is the most common site for verruciform xanthoma

A

gingiva

42
Q

The blue color of a blue nevus is due to

A

Tyndall effect

43
Q

What is the definition of leukoplakia

A

an intraoral white plaque that does not rub off and cannot be identified as any other well known entity.

44
Q

What are some white lesions that can be scraped off

A 
Materia alba
white coated tongue
burn
Pseudomembranous candidiasis
sloughing from toothpaste
45
Q

What is the etiology of leukoplakia

A 
tobacco
alcohol
sanguinaria
UV rad
microorganisms
trauma
46
Q

Where are 70% of leukoplakia lesions found

A

lip vermilion
buccal mucosa
gingiva

47
Q

Leukoplakia with 90% dysplasia or carcinoma is found in

A

Lip vermillion
lateral/ventral tongue
FOM

48
Q

lesions that demonstrate scattered red patches are termed

A

erythroplakia

49
Q

Red and white intermixed lesions are termed

A

erythroleukoplakia

50
Q

What does PVL stand for

A

Proliferative verrucous leukoplakia

51
Q

Does PVL have an association with tobacco use

A

No

52
Q

What % of leukoplakias become SCCA and within what time frame

A

5% within 2-4 yrs

53
Q

What factors increase the risk for cancer in leukoplakia

A

persistent over several years
female ptn
Non-smoker
FOM or ventral tongue lesions

54
Q

Smokeless tobacco keratosis presents with NO

A

Induration
ulceration
Pain

55
Q

What disease is linked to chronic placement of betel quid or paan

A

Oral submucous fibrosis

56
Q

What is quid

A 
Areca nut
slaked lime
betel leaf
tobacco 
sweteners
57
Q

What is the CC of oral sub mucous fibrosis

A

trismus

mucosal pain from eating spicy foods

58
Q

What are 12 possible contributors to SCCA

A 
o	Tobacco 
o	Betel Quid
o	Alcohol
o	Phenolic agents
o	Radiation
o	Iron deficiency
o	Vitamin-A deficiency
o	Syphilis
o	Oncogenic viruses
o	Immunosuppression
o	Oncogenes 
o	Tumor suppressor genes
59
Q

What is the relative risk fro oral SCCA for a smoker

A 
2ppd= 5
4ppd= 17
60
Q

Wood industry workers are exposed to —- leading to SCCA

A

phenoxyacetic acids

61
Q

Vitamin A deficiency leads to excessive prod of

A

keratinization

62
Q

What HPV viruses are considered oncogenic

A

16
18
31
33

63
Q

Distant metastasis is most commonly found in

A

Lungs
Liver
Bones

64
Q

Meaning of X following TNM

A

No available information

65
Q

Meaning of O following TNM

A

No evidence of distant metastasis

66
Q

What carcinoma has a “deceptively benign” microscopic appearance

A

Verrucous carcinoma

67
Q

Melanoma invasions > ___ mm in oral mucosa has poor diagnosis

A

0.5 mm

68
Q

What are the histologic categories for leukoplakia

A

Mild 1/2

Carcinoma in situ

Pathology (17 decks)

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