Cervical Dysplasia

Question 1

What are the histological gradings of cervical dysplasia?

Answer 1

HPV, CIN 1 - 3

Question 2

What are the cytological gradings of cervical dysplasia? and how do they correlate to the histological grading

Answer 2

low grade squamous intraepithelial lesion (HPV+CIN1)

High grade, corresponding to CIN2 and 3

Question 3

Which strain of HPV accounts for most of the dysplasia cases

Answer 3

HPV 16 and 18

Question 4

Which age group is at the highest risk for HPV infection

Answer 4

20-24

Question 5

HPV has early and late genes. What do the late genes encode? What do the early genes encode?

Answer 5

late - capsule proteins

early - proliferative proteins

Question 6

T/F The cervical epithelium needs to be damaged before HPV can cause damage

Answer 6

True

Question 7

Three important proteins are important in HPV infection. What are they and what are their functions

Answer 7

E2 - suppress E6 and E7

when inhibition is lifted (E2 incorporated into host genome)

E6 - suppress p53
E7 - suppress retinoblastoma gene

Question 8

Which zone in the cervix is most prone to HPV infection

Answer 8

Transitional zone

Question 9

Can we get glandular dysplasia in the cervix

Answer 9

No, only adenocarcinoma in situ

Question 10

How are CIN1, 2, 3 differentiated

Answer 10

There are three layers above the basal lamina on transitional zone
CIN1 - only affects the basal layer
CIN2- affecting middle layer
CIN3- affecting the entire thickness