centeral a-2 agonists Flashcards
1
Q
MOA
A
acts centrally to stimulate alpha receptors decrease in sympathetic outflow and decreased blood pressure
2
Q
drug names
A
- Methyldopa
- Clonidine
- Clonidine patch
- Guanabenz
- Guanfacine
3
Q
indication
A
- No recommendations at this time
* Useful in hypertensive urgency
4
Q
adverse effect
A
- Transient sedation initially
- Hepatotoxicity, hemolytic anemia, peripheral edema (methyldopa)
- Orthostatic hypotension (methyldopa, clonidine)
- Dry mouth, muscle weakness (clonidine)
- Sexual dysfunction
5
Q
comments
A
- Avoid in HF
- Rebound HTN if withdrawn quickly
- Methyldopa: 1st line in pregnancy
- Tolerance may occur 2-3 months after start of methyldopa; increase dose or add diuretic
- Contraindications:
- Hypersensitivity
- Concurrent use of MAO inhibitors (methyldopa)
- Hepatic disease (methyldopa)