centeral a-2 agonists Flashcards

1
Q

MOA

A

acts centrally to stimulate alpha receptors  decrease in sympathetic outflow and decreased blood pressure

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2
Q

drug names

A
  • Methyldopa
  • Clonidine
  • Clonidine patch
  • Guanabenz
  • Guanfacine
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3
Q

indication

A
  • No recommendations at this time

* Useful in hypertensive urgency

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4
Q

adverse effect

A
  • Transient sedation initially
  • Hepatotoxicity, hemolytic anemia, peripheral edema (methyldopa)
  • Orthostatic hypotension (methyldopa, clonidine)
  • Dry mouth, muscle weakness (clonidine)
  • Sexual dysfunction
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5
Q

comments

A
  • Avoid in HF
  • Rebound HTN if withdrawn quickly
  • Methyldopa: 1st line in pregnancy
  • Tolerance may occur 2-3 months after start of methyldopa; increase dose or add diuretic
  • Contraindications:
  • Hypersensitivity
  • Concurrent use of MAO inhibitors (methyldopa)
  • Hepatic disease (methyldopa)
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