CCB drugs

Question 1

Non-
dihydropyridine
MOA

Answer 1

CCB
Non-
dihydropyridine
a slow calcium channel blocker that blocks calcium ion influx during depolarization of cardiac and vascular smooth muscle. It decreases peripheral vascular resistance and causes relaxation of the vascular smooth muscle resulting in a decrease of both systolic and diastolic blood pressure

Question 2

Non-
dihydropyridine
Drug names

Answer 2

• Diltiazem long-acting

* Verapamil sustained-release

Question 3

Non-
dihydropyridine
indication

Answer 3

• High coronary disease risk (verapamil-trandolapril )

Question 4

Non-
dihydropyridine
adverse effect

Answer 4

• Bradycardia
• Heart block
• Constipation
• Hypotension
• Peripheral edema
• HA
• Flushing

Question 5

Non-
dihydropyridine
monitoring

Answer 5

• Heart rate: caution with HR <60

Question 6

Non-
dihydropyridine
comments

Answer 6

• Use caution in concomitant use with B-blocker  heart block
• Potent CYP inhibitors: DDI’s
Contraindication:
• Hypersensitivity
• Sinus node dysfunction/severe sinus bradycardia (w/o pacemaker)
• Atrial fibrillation/flutter
• Severe hypotension (systolic <90mmHg)
• Severe L ventricular dysfunction (EF <40%)

Question 7

Dihydropyridines

MOA

Answer 7

Inhibits calcium ion from entering the slow channels of vascular smooth muscle and myocardium during depolarization  relaxation of coronary vascular smooth muscle and coronary vasodilation
- acts on vascular smooth muscle to produce peripheral arterial vasodilation

Question 8

Dihydropyridines

drug names

Answer 8

• Amlodipine
• Felodipine
• Isradipine SR
• Nicardipine SR
• Nifedipine long-acting
• Nisoldipine

Question 9

Dihydropyridines

indication

Answer 9

• First line option

Question 10

Dihydropyridines

adverse effect

Answer 10

• Gingival hyperplasia
• Reflex tachycardia (SOB)
• Peripheral edema
• Constipation

Question 11

Dihydropyridines

comment

Answer 11

• Start at low dose in elderly pts