ARB Flashcards
1
Q
MOA
A
ARB
a reversible, non-competitive, angiotensin II receptor antagonist. It deters vasoconstriction and aldosterone-secreting effects by specifically intercepting the binding of angiotensin II to the AT(1) receptor
2
Q
Drug names
A
- Candesartan
- Eprosartan
- Irbesartan
- Losartan
- Olmesartan
- Telmisartan
- Valsartan
3
Q
indication
A
- Heart failure (valsartan, candesartan)
- High coronary disease risk (losartan)
- DM
- CKD (irbesartan, losartan)
4
Q
adverse effect
A
- Hyperkalemia
- Increase in sCr (<35% acceptable)
- Angioedema (less than ACEI)
- Hypotension/syncope
- Cough
- rash
5
Q
monitoring
A
- Electrolytes (K)
- Renal function (sCr, BUN)
- 7-14 days after initiation/dose change
6
Q
comment
A
Contraindication:
• Pregnancy (avoid in 2nd/3rd trimesters)
• Angioedema
• Bilateral renal artery stenosis