ARB Flashcards

1
Q

MOA

A

ARB
a reversible, non-competitive, angiotensin II receptor antagonist. It deters vasoconstriction and aldosterone-secreting effects by specifically intercepting the binding of angiotensin II to the AT(1) receptor

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2
Q

Drug names

A
  • Candesartan
  • Eprosartan
  • Irbesartan
  • Losartan
  • Olmesartan
  • Telmisartan
  • Valsartan
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3
Q

indication

A
  • Heart failure (valsartan, candesartan)
  • High coronary disease risk (losartan)
  • DM
  • CKD (irbesartan, losartan)
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4
Q

adverse effect

A
  • Hyperkalemia
  • Increase in sCr (<35% acceptable)
  • Angioedema (less than ACEI)
  • Hypotension/syncope
  • Cough
  • rash
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5
Q

monitoring

A
  • Electrolytes (K)
  • Renal function (sCr, BUN)
  • 7-14 days after initiation/dose change
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6
Q

comment

A

Contraindication:
• Pregnancy (avoid in 2nd/3rd trimesters)
• Angioedema
• Bilateral renal artery stenosis

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