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Cell Bio Final > Cell Signaling Part 2 > Flashcards

Cell Signaling Part 2 Flashcards

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Biology 101 flashcards
1
Q

transmembrane proteins that display their ligand binding domains on the outer surface of the plasma membrane

A

enzyme coupled receptors

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2
Q

largest class of enzyme coupled receptors

A

receptor tyrosine kinase

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3
Q

ligand binding allows —- formation which results in —-

A

dimer, kinase activation

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4
Q
  • a small GTP binding protein that is bound by a lipid tail to the cytoplasmic face of the plasma membrane
  • a monomeric GTPase
A

Ras

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5
Q

virtually all RTK’s actiavte

A

Ras and PDGF

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6
Q

mediate cell proliferation in wound healing and nerve growth factor receptors

A

PDGF

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7
Q

Ras-Gef activates or deactives Ras?

A

activates (turns on)

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8
Q

Ras-Gap activates of deactivates Ras?

A

deactives

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9
Q

upon activation of Ras, it will activate what?

A

MAP Kinase Module

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10
Q

MAP kinases change what two things

A

protein activity, and gene expression

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11
Q

growth factor signaling

A

ras/raf/mek/erk/transcription factor activation

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12
Q

RTK’s activate to promote cell growth and survival

A

PI3K pathway

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13
Q

PI3K pathway

A

Signal — pip2 - PI3K - pip3 (PTEN) - AKT - MTOR - C1 AND C2

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14
Q

rapator

A

c1

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15
Q

rictor

A

c2

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16
Q

insulin signaling

A

pi3k/akt (draw out)

17
Q

54 kDa lipidphosphatase

the second most frequently mutated gene in human cancer

functions to antagonize PI3K/Akt signaling

A

PTEN

18
Q

cytokine signaling

A

jak/stat (draw out)

19
Q

signaling through interferons and hematopoietic receptors occur through the

A

JAK-STAT pathway

20
Q

inhibitors of the JAK-STAT pathway

A
  • protein inhibitor of activated STAT (PIAS)

- suppressor of cytokine signaling (SOCS)

21
Q

family of 8 mobile transcription factors

A

smad family proteins

22
Q

3 different types of smads

A

r
co
I

23
Q
  • regulated by phosphorylation

- smad 1 2 3 5 8

A

r smads

24
Q

is not phosphorylated itself

smad 4

A

co smad

25
Q

inhibitory - present other scads from phosphorylation

smad 6 7

A

I-smad

26
Q

smad’s are used in what signaling

A

transforming growth factor -beta (TGF-beta)

27
Q

TGF-b signaling

A
  • ligand binds and is phosphorylated smad 2 or 3
  • joins with 4 to make complex
  • can enter nucleus for transcription
28
Q

cells transmit information from ER to nucleus

A

regulated intramembrane proteolysis

29
Q

No phosphates being shuttled around
Notch signaling
Amyloid precursor protein (APP)
Sterol synthesis

A

regulated intramembrane proteolysis

30
Q

Communication and interconnectivity between signaling pathways

A

cross talk

31
Q

Notch1 Intersection with

A

mTOR and PTEN

Cell Bio Final (8 decks)

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