Cell Bio VII Flashcards
Nucleostemin
p53 binding protein found in undifferentated cells. Decreases as cells become differentiated. Presence in cancer cells may play a role in unchecked proliferation.
Colchicine, vicristine, and vinblastine inhibit what
polymerization of microtubules
Taxol
promotes polyermization and inhibits depolymerization
Stages of Mitosis
Metaphase, Anaphase, Telophase, Cytokinesis
Metaphase
Chromosomes line up at equator. Kintochore microtubles attach sister chromatids to opposite poles of the spindle
Anaphase
sister chromatids separate, form 2 daughter chromosomes where are pulled towards the poles. Kinetochore microtubules get shorter, spindle poles move apart
Telophase
Sister chromatids arrive at poles of the spindle and decondense. New nuclear envelope forms around each set
Cytokinesis
Cytoplasm is divided into two by contractile ring made up of actin and myosin filaments that pinch the cell in two, creating two daughter cells, each with one nucleus
Cytochalasin B
Inhibits polymerization of actin microfilaments
Telomeres in stem cells
Telomerase is present, so length of telomere is maintained
Telomeres in somatic cells
Telomerase is not present. Length of telomere gets reduced. Chromosome becomes unstable, eventually apoptosis occurs
Two walls of cell death
neurosis and apoptosis
Necrosis
more violent, cell explodes, ends up with an immune response
Apoptosis
less violent, no immune response
Phosphatidylserine
Gets flipped from the cytosolic monolayer to the extracellular monolayer where it acts as a target for apoptosis
