Cell Bio V Flashcards
Coating Protein I
Retrograde movement, from golgi back to ER
Coating Protein II
entrograde movement, from ER to golgi
SNAREs
used for direct movement
v-SNARE
recognizes the t-SNARE at the golgi
Reasons why we need retrograde flow
- Maintain membrane balance
- Recycle SNAREs so you don’t have to reuse them
- In case of misdelivery
Botulinum toxin A
disrupts neurotransmission, gets rid of target SNARE. Causes muscle paralysis (botox)
Mitochondrium
- Has outer and inner membrane
- Inner membrane has folding which are called cristis
- Not all cells have mitochondrium
- Have to stain in order to see
High amounts of cristi means
making a high amount of ATP
Low amounts of cristi means
making a low amount of ATP
Where do CO and cyanide poisoning have an affect
enzymes on the inner MM
Palocyte arrangemnt
looks like picket fense
Tubular cristae
- Hallmark feature of cells that synthesize steriod hormones
- Will also find precursors of cholesterol (lipid droplets)
What does steriod hormone synthesis require?
mitochondrial and sER enzymes
MERRF
- Has red appearing mitochondria
- Has parking lot inclusions in mitochondria
Functions of peroxisomes
- beta oxidation of FFAs
- plasmalogen synthesis
- regulate H2O2
- kill pathogens
- oxidize EtOH
Zellweger syndrome
impaired import of enzymes into peroxisomes
Cytoskeleton elements
microtubules and filaments
Types of filaments
actin, intermediate, myosin
Kinesin
microtubule motor. Takes synaptic vesicle from negative to positive end of the microtubule
