cell bio final Flashcards
the phase of the eukaryotic cell cycle between the end of cytokinesis and the start of DNA synthesis
a. cdk-activating kinase
b. S phase
c. M phase
d. G1
e. cyclin-dependent kinase
f. cyclin inhibiting protein kinase
g. APC/C
h. Cdc25
D
A member of the family of protein kinases that have to be complexed with a cyclin protein in order to act
a. cdk-activating kinase
b. S phase
c. M phase
d. G1
e. cyclin-dependent kinase
f. cyclin inhibiting protein kinase
g. APC/C
h. Cdc25
e
the ubiquitin ligase that promotes the destruction of a specific set of proteins, thereby promoting the separation of sis chromatids and completion of m phase
a. cdk-activating kinase
b. S phase
c. M phase
d. G1
e. cyclin-dependent kinase
f. cyclin inhibiting protein kinase
g. APC/C
h. Cdc25
G
mitogens are added to medium of cultured human cells that are synchronized in mitosis. the mitogen is washed away after these cells have passed the restriction point in the cell cycle. these cells will progress through the cell cycle, then arrest in which phase?
a. s phase
b. g2
c. mitosis
d. g0/g1
e. these cells will progress repeatedly through the cell cycle without arresting
d
t or f: the concentration of cyclins fluctuates throughout the cell cycle, while CDK concentrations dont
t
how are mitotic cyclin/cdk complexes activated
a. phosphorylation of cdk
b. dephosphorylation of cdk
c. both phosphorylation and dephospho rylation of cdk
d. release and degradation of inhibitory protein from cdk
a
how does nuclear envelope dissociate during mitosis
a. ubiquitin ligases degrade nuclear pore proteins
b. dephosphorylation causes nuclear pore proteins to degrade
c. phosphorylation causes nuclear pore proteins to degrade
d. microtubule formation causes nuclear pore proteins to degrade
c
what is the function of e2f in the cell cycle
a. acts as inhibitor of Rb protein
b. ubiquitin ligase for s-phase cyclins
c. acts to phosphorylate and activate S-phase cyclins
d. is a TF
e. is a phosphatase
d
what is the function of a Cdc in the cell cycle
a. acts as inhibitor of Rb protein
b. ubiquitin ligase for s-phase cyclins
c. acts to phosphorylate and activate S-phase cyclins
d. is a TF
e. is a phosphatase
e
which one of the following is encoded by a tumor suppressor gene?
a. fos
b. myc
c. ras
d. Rb
e. HER2
D
describes a tumor/tumor cell that can invade surrounding tissue or form tumors at other sites in the body
a. sarcoma
b. carcinoma
c. leukemia
d. benign
e. malignant
f. metastatic
e
a cancer arising from epithelial cells
a. sarcoma
b. carcinoma
c. leukemia
d. benign
e. malignant
f. metastatic
b
describes a tumor that is self-limiting in growth and non-invasive
a. sarcoma
b. carcinoma
c. leukemia
d. benign
e. malignant
f. metastatic
d
where does the mutation in Ras most often occur?
a. a chromosomal translocation, in which part of the Ras gene is fused to the immunoglobulin heavy chain
b. a chromosomal deletion, in which the ligand-binding domain is removed
c. a point mutation in the transmembrane domain of Ras
d. a point mutation in the GTP binding domain
e. a point mutation in the Raf binding site
D
true or false: all carcinogens are mutagens
f
