CDA - Glaucoma Flashcards

1
Q

What are some red flag indicators for headache?

A
  • Sudden onset especially if no POH
  • Severe debilitating pain +/- wakes at night
  • Progressive
  • Worse when bending, sneezing
  • Worse in the morning
  • young obese female (pseudotumor cerebri, IIH)
  • new >50 years of age (Giant cell arteritis)
  • history of recent trauma (IIH)
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2
Q

Red flag indicators for headache and associated symptoms?

A
  • Fever (meningitis)
  • Vomiting (IIH)
  • migraine (IIH)
  • Seizures (epilepsy, haemorrhage, infection)
  • diplopia, CN palsy, blurry VA –> GCA, IIH, stroke)
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3
Q

What tests would you do for a patient with a headache?

A

Vision, VA
Pupils
Colour vision (Ishihara)
Dilated Fundus examination, optic nerve assessment
Visual field –> associated IIH, papilledema, optic atrophy/ neuropathy
OCT –> IIH, Papilledema, optic atropy, optic neuropathy

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4
Q

List some DDx for a patient c/o “blurry vision in both eyes and headaches”
Patient is a 31y.o Female
Obese

A
  • Bilateral optic nerve swelling
  • IIH
  • Papilledema
  • Severe hypertension
  • Papillitis
  • Optic neuritis
  • Optic nerve glioma
  • Acute angle closure glaucoma
  • Glaucoma suspect
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5
Q

31 year-old female social worker who presents with 2 month history of fluctuating vision in both eyes. The blurriness has become more permanent in the R>L for the last 3 weeks. Vision is worse when lying down; at times her vision goes completely dark in both eyes. Patient denies flashes or floaters. She has noticed some diplopia side to side when watching TV, occasionally, in the last 3 months.

She also reports headaches - intense and persistent- over her whole head for the last month. She though maybe due to the blurry vision. Headaches are also worse when lying down. She can also hear a whooshing sound in her ears once-in-a-while “as if I was listen to the waves”.

List the more likely DDx

A
  • Inner ear infection
  • IIH
  • Optic nerve head swelling
    Papillitis
    Severe hypertension
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6
Q

Further history and results:
VA reduced in LE 6/60 and RE 6/6
L RAPD present
Nil other POH, GH,
CT D and N: //
VF: significant decrease of VF in OU with preserved central vision
MRI: large supraselllar mass abutting the R optic nerve and displacing the L optic nerve

A

Diagnosis
Bilateral optic nerve head swelling, due to intracranial mass

Tx: referral and evaluation by neurosurgeon.
Acetazolamide (Diamox) to reduce the intracranial pressure
Lifelong permanent vision loss

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7
Q

Define glaucoma

A

Optic atrophy
Optic neuropathy with progressive ONH damage and characteristic VF loss

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8
Q

What is the 1 modifiable factor you can change with glaucoma?

A

IOP

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9
Q

How would you explain this?
Where would the subsequent VF loss be at?

A

It is glaucomatous ONH
C/D 0.8
the arrow points to a notch (remember: the inferior and superior poles of the ONH show signs of atrophy first)
VF loss –> superior arcuate loss

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10
Q

Are these two ONH glaucomatous?

A

NO
They are normal ONH because:
- we need to factor in the neuroretinal rim and ask ourselves does it follow the ISNT rule
- the ISNT rule: the rim is thickest at its inferior, superior, nasal and temporal.
- if the ONH follows the ISNT rule, then it isnt glaucomatous (Does not apply to all cases, but most)

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11
Q

Which field represents the L VF and R VF?
How far does the normal VF extend superiorly, inferiorly, nasally and temporally?
How far away from the centre is the blind spot?

A

The blind spot is approx 15 degrees temporal to the centre.

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12
Q

Overview of VF loss and how a nasal step can become much worse if left untreated

A
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13
Q

What is this?
Where is it found more often?

A

Sampaolesi line
Line of pigment present anterior (above on gionioscopy) to Schwalbe’s line in the angle.

It is more common in PXS (pseudoexfoliation syndrome) and less in pigment dispersion syndrome.

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14
Q

What is this?
Where is it more commonly found?

A

Scheie stripe
More commonly found in PDS/PG.
Pathogonomonic

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15
Q

What is this?
Where is it found?

A

Fibrillar material on anterior capsule in a target like distribution.
More so in PXS
The movement of iris across the capsule as the pupil dilates and constricts –> causes distribution of the material

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16
Q

The difference between PXS and PDS/PG

A
17
Q

PXS and the Scandinavian population

A

approx 50% of all AOG cases among Scandinavians are PXS

18
Q

What is pilocarpine? How does it work?

A

Pilocarpine is a muscarinic agonist.
It activates the muscarinic AChR which constricts pupils.
Leads to increased TRABECULAR outflow

19
Q

What are carbonic anhydrase inhibitors

A

E.g. is Dorzolamide
Decreases aqueous humour secretion
Brinzolamide

20
Q

How do prostaglandins help in IOP Mx?

A

increase uveoscleral outflow
e.g. brimatoprost
Latanoprost
Travoprost

21
Q

Mechanism of action of B-adrenergic antagonist

A

Decrease aq humour production
e.g.
Timolol
Betaxolol

22
Q

Mechanism of action of a-2 adrenergic receptor agonist

A

Decrease aq humour production
increase uveoscleral outflow
e.g.
Brimonidine

23
Q

How does central corneal thickness affect IOP?

A

Average corneal thickness is 550um
Greater CCT ==> overestimation of IOP
reduced CCT ==> underestimation of IOP