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Kaplan: Immunology > CD Markers > Flashcards

CD Markers Flashcards

1
Q

Another name for CD2?

A

LFA-2

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2
Q

Where is CD2 expressed?

A

T cells, thymocytes, NK cells

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3
Q

What are some known functions of CD2?

A

adhesion molecule

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4
Q

Where is CD 3 expressed?

A

T cells, thymocytes

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5
Q

What is the function of CD3?

A

signal transduction by the TCR

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6
Q

Where is CD4 expressed?

A

Th cells, thymocytes, monocytes, and macrophages

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7
Q

Function of CD4?

A

coreceptor for TCR-MHC class I-restricted T cells

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8
Q

Where is CD8 expressed?

A

CTLs, some thymocytes

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9
Q

What is the function of CD8?

A

coreceptor for MHC class I - restricted T cells

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10
Q

Where is CD14 expressed?

A

monocytes, macrophages, granulocytes

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11
Q

What is another name for CD14?

A

LPS receptor

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12
Q

Function of CD 14?

A

binds LPS

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13
Q

What is another name for CD16?

A

Fc receptor

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14
Q

Where is CD16 expressed?

A

NK cells, macrophages, neutrophils

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15
Q

Function of CD16?

A

opsonization of ADCC

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16
Q

Where is CD18 expressed?

A

leukocytes

17
Q

What is the function of CD18?

A

cell adhesion molecule (missing in leukocyte adhesion deficiency)

18
Q

Where is CD19 found?

19
Q

What is the function of CD19?

A

co-receptor with CD21 for B-cell activation (signal transduction)

20
Q

Where is CD20 expressed?

A

most or all B cells

21
Q

What is the function of CD20?

A

unknown role in B-cell activation

22
Q

Where is CD21 expressed?

A

mature B cells

23
Q

Other name for CD21?

A

CR2, C3d receptor

24
Q

What is the function of CD21?

A

receptor for complement fragment C3d, forms co-receptor complex with CD19, EBV receptor

25
Q

CD25 is expressed where?

A

activated Th cells and Treg

26
Q

What is the function of CD25?

A

Alpha chain of IL-2

27
Q

Where is CD28 expressed?

28
Q

What is the function of CD28?

A

T-cell receptor for co-stimulatory molecule B7

29
Q

Where is the CD34 marker found?

A

precursors of hematopoietic cells, endothelial cells in HEV

30
Q

What are the functions of CD34?

A

cell-cell adhesion, binds L-selectin

31
Q

Where are CD40 markers found?

A

B cells, macrophages, dendritic cells, endothelial cells

32
Q

What is the function of CD40?

A

Binds CD40L, role in T-cell- dependent B cell, macrophage, dendritic cell and endothelial cell activation

33
Q

Where are CD56 markers found?

34
Q

Function of CD56?

A

cell adhesion

35
Q

Where are CD152 markers expressed?

A

Activated T cells

36
Q

Another name for CD152 markers?

37
Q

Function of CD152 markers?

A

negative regulation: competes with CD28 for B7 binding

Kaplan: Immunology (16 decks)

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