CC: Uremia Flashcards
What is azotemia?
High Blood Nitrogen
What is uremia?
Clinical disease resulting from azotemia.
Is an azotemic animal always uremic?
Nope.
Is a uremic animal always azotemic?
Yup.
What was up with Opus’s urinalysis?
SG: 1.012 (low for being dehydrated)
pH 6.5
RBC: 9-10 (shouldnt be any)
WBC: 2-3 (shouldn’t be any)
What was up with Opus’s chemistry profile?
Hyperproteinemia
really really high BUN
really really high Creatinine
really high Phosphorous
Signs pointing towards kidney problems
Where is urea produced?
LIVER, only the LIVER. nowhere but the LIVER!
Is urea production variable?
Yup.
What’s the substrate source for urea?
Protein
How is urea made?
Urea Cycle in the liver!
Where is creatinine produced? Is its procution constant? what’s its substrate source?
Muscle; constant; muscle; excreted in urine
How do you get increased production of urea?
high protein diet GI hemorrhage fever tissue trauma (inc. released AAs) drugs: Corticosteroids (cortisol), tetracycline Protein Catabolism
What are reasons for decreased production of urea?
Low protein diet
Hepatic insufficiency
Polyuria-polydipsia (drinking a lot will dilute the concentration and make it appear low)
What are causes of elevated Creatinine?
Pre-renal: low flow of blood (not able to filter)
Renal: loss of glomerular function (poor/not filtering)
Post-renal: obstruction (can’t get out)
What are causes of decreased creatinine?
Loss of Muscle mass
Cachexia - muscle wasting
cancer and starvation can cause this