CC: Polysaccharide Storage Myopathy Flashcards
What was wrong with this horse?
GLYCOGEN SYNTHASE was always on. So glucose levels in the body were constantly being depleted but since she was exercising consistently she was continually breaking down the glycogen. When she rested for the foot abscess the pathology was able to make a significant impact on the horses health.
The buildup of glycogen destroyed her muscle cells.
How should she be treated?
HAY feed + no grain = minimize carbs for glycogen synthesis
Rest but not too long, couple days.
Other therapeutics like NSAIDs, fluid and anxiety relief
DAILY exercise and routine to break down glycogen
Why is HYPERGLYCEMIA so bad?
Glucose is an ALDEHYDE SUGAR – VERY Reactive
In the CNS, because they are highly reactive, they tend to form crosslinks –> they Bind and will spontaneously add themselves to molecules especially PROTEINS
Glycosylated Proteins at a rate faster than can be corrected. Changing their structure changes their function. Extremeties take the biggest hit, FEET most common and Fingers.
Glycosylated axons will no longer carry depolarizations ==> NEUROPATHY
Kidneys will also take a hit -> Kidney failure in diabetics. Mess up endothelium of capillary surfaces.
Reduced circulation and innervation can lead to no sensation of gangrene onset
