CB7

Question 1

haemostasis is about finding the balance between _____ and ______

Answer 1

bleeding and coagulation

Question 2

what are 5 important things the body must do when injury occurs?

Answer 2

Question 3

deep vein thrombosis is caused by _______

Answer 3

blood stasis, when blood pools in an area of your body

Question 4

DVT clots form in the ______ veins, usually in the _____

Answer 4

deep, leg

Question 5

a DVT clot is very dangerous if it becomes _________, enters the _______, and gets lodged in the _______

Answer 5

detatched, bloodstream, lungs

Question 6

what is a pulmonary embolism (PE)

Answer 6

pulmonary artery gets blocked due to a clot, usually from a DVT clot

Question 7

__-__% of people with DVT/PE die within months of diagnosis

Answer 7

10-30

Question 8

what is a myocardial infarction?

Answer 8

it is when the coronary artery gets blocked by a clot

Question 9

where does the clot in a myocardial infarction usually originate from?

Answer 9

atherosclerotic plaque

Question 10

what happens to the heart tissue that is normally supplied from the occluded blood vessel?

Answer 10

it dies

Question 11

______________ is the leading killer of men and women in the US

Answer 11

myocardial infarction

Question 12

an ischemic stroke occurs when an _______ to the brain is blocked, depriving the brain of _____________. This kills brain _______.

Answer 12

artery, oxygenated blood, tissue

Question 13

know everything about coagulation cascade

Question 14

what are the 3 central roles of thrombin?

Answer 14

activates platelets, cleaves fibrinogen to fibrin, and feedback amplification (FV, FVIII, FXI)

Question 15

what are the similarities (4) between procoagulants and anticoagulants

Answer 15

made by liver and released into plasma, vitamin K helps it function, made of similar domains, activation might include cleavage of an activation peptide

Question 16

before it gets released into the plasma, Gla (gamma-carboxyglutamic acid) undergoes ________

Answer 16

post-translational modification

Question 17

Gla domains are _________ dependent

Answer 17

vitamin k

Question 18

Gla is essential for normal functional activity such as __________

Answer 18

binding to phospholipid membranes

Question 19

warfarin prevents ______ domain function in _______ enzymes

Answer 19

Gla, coagulation

Question 20

coagulation facts 5 and 8 act as ______ rather than serine proteases

Answer 20

cofactors

Question 21

not all coagulation proteins are ______

Answer 21

enzymes