Case of Worried Midwife

Question 1

acute myeloid leukaemia signs?

Answer 1

thrombocytopenia, neutropenia, primitive myeloid blast cells, auer rods

Question 2

AML markers?

Answer 2

CD33 and CD 117

Question 3

neutropenic fever antibiotics

Answer 3

tazocin teicoplanin

Question 4

APML RARA treatment

Answer 4

all-trans retinoic acid vitamin A
arsenic

Question 5

retinoic acid can cause?

Answer 5

release of wbc which settle in lungs resulting in ATRA syndrome

Question 6

tersons syndrome

Answer 6

intraocular haemorrhage following subarrachnoid haemorrhage

Question 7

what is APML complicated with?

Answer 7

DIC

Question 8

APML mutation

Answer 8

translocation 15 and 17
PML and RARA

Question 9

what is indicative of chronic myeloid leukaemia?

Answer 9

lots of myeloid cells at different stages of maturation

Question 10

CML mutation

Answer 10

translocation 9 and 22 BCR-ABL philadelphia chromosome

Question 11

How to block ABL mutation

Answer 11

tyrosine kinase inhibitor imatinib

Question 12

How do you monitor unfractionated heparin?

Answer 12

APTT

Question 13

warfarin inhibits which factors?

Answer 13

2,7,9 and 10

Question 14

factor 10 inhibitors?

Answer 14

apixaban rivoraxaban

Question 15

direct thrombin inhibitor/ factor 2?

Answer 15

dabigatran

Question 16

how does clopidogrel work?

Answer 16

inhibits binding of ADP to P2Y12 receptor

Question 17

prothrombinase contains?

Answer 17

factor 10 and 5 and calcium and phospholipid