Case of Unrelenting Diarrhoea Flashcards
1
Q
definition of diarrhoea?
A
increase in frequency over 3 and increase in volume 250g
2
Q
which cells are predominantly present on right side of colon?
A
paneth cells
3
Q
what does normal large intestine have
A
more plasma cells at top of crypt, more on right
4
Q
what do you see in acute colitis?
A
oedema, active inflammation neutrophil polymorphonuclear cells, absence of paneth cell hyperplasia, no fibrosis, no ulcer associated cell lineage, retention of normal crypt architecture
5
Q
features of chronic colitis?
A
distortion of crypt architecture, loss of inflammatory gradient, basal plasmacytosis, paneth cell and neuroendocrine hyperplasia, ulcer associated lineage and fibrosis
6
Q
what is contraindicated in pregnancy?
A
ACEi and ARBs
7
Q
what is highly teratogenic?
A
isotretinoin
