Case Of Man Who Wanted To Know Future

Question 1

How does PET/FDG imaging work?

Answer 1

Cancers metabolise glucose at a faster rate. Give flourodeoxyglucose, which releases photons 2

Question 2

Pain killing properties from willow component?

Answer 2

Salicin

Question 3

Aspirin comes from?

Answer 3

Spiraea ulmaria

Question 4

Aspirin can cause?

Answer 4

Gastroenteritis

Question 5

Opium is derived from?

Answer 5

Papaver somniferum

Question 6

Difference in opiate and opioid?

Answer 6

Opioids are synthetic/natural substance
Opiates - derived naturally from opium poppy

Question 7

NSAIDs take how long for full effect analgesic?

Answer 7

1 week

Question 8

How long does it take for NSAID full anti inflammatory effect?

Answer 8

3 weeks

Question 9

How do NSAIDs work as anti-pyretics?

Answer 9

In a inflammatory reaction IL1 releases prostaglandins which elevate hypothalamic set point for temperature control

NSAIDs prevent this

Question 10

Cut off for using alternative oxycodone?

Answer 10

35 ml/min eGFR

Question 11

What do NSAIDs do in kidney?

Answer 11

Dilate afferent arteriolar

Question 12

Higher doses of codeine cause problems?

Answer 12

Constipation

Question 13

What does diclofenac do to stomach lining?

Answer 13

Prostaglandin inhibitors, which are gastroprotective

Question 14

Why does NSAIDs worsen asthma?

Answer 14

Inhibition of COX1, activates lipoxygenase pathway which increases leukotrienes that induced bronchospasm

Question 15

Prostacyclin causes?

Answer 15

Vasodilation, inhibition of platelet aggregation

Question 16

Issues with cox 2 selective meds?

Answer 16

Imbalance
Vasoconstriction, platelet aggregation
Can cause clots MI etc

Question 17

What would you prescribe if having morphine for the first time? Constipation?

Answer 17

Osmotic laxative
And antiemetic-metocloperamide

Question 18

Which drugs can cause gout?

Answer 18

Bendroflumethiazide

Question 19

Treatment of gout

Answer 19

1. NSAIDs
   If contraindicated-colchicine