Case of Headache

Question 1

phases of migrane?

Answer 1

prodrome, aura, migraine attack, postdrome

Question 2

predisposing factors to migraine?

Answer 2

genetic 38 genomic loci associated, familial hemiplegic migraines

Question 3

how do gene mutations cause migraines?

Answer 3

increase glutamate release therefore enhanced neuronal activation and lowers threshold for cortical spreading depression

Question 4

prodrome of migraine?

Answer 4

fatogue/cognitive change
homeostatic alterations
sensory sensitivities/non painful migranous symptoms

Question 5

aura of migraine ?

Answer 5

zig zag lines, visual fortification, speech dysphasia, sensory disturbance

Question 6

what causes cortical spreading depression?

Answer 6

increased extracellular potassium and glutamate secretion

Question 7

how to prevent migraines?

Answer 7

topiramate, amitryptylline propanolol

Question 8

where is CGRP released from?

Answer 8

c and adelta fibres
and acts on CGRP receptors