Case Of Samba Playing Grandma Flashcards
CLL markers diagnosis?
Clonal and atypical, CD5 T cell and CD19 B cell marker
How to stage CLL?
Binet staging
B symptoms?
Weight loss 10 % in 6 months, night sweats, fevers
When your lymphocytes increases how does it affect your bone marrow?
Low Hb, low platelets
Which mutations detected in CLL in FISH?
17 p loss
P53 mutation
13q deletion
Briton tyrosine kinase inhibitor cause?
Prevents B cells dividing , B cells die
Antiapoptotic protein which causes leukaemia?
Bcl2
Venetoclax inhibits bcl2
Tumour lysis syndrome?
Drugs which cause apoptosis
High potassium high phosphate low calcium raised creatinine
Chronic lymphocytic leukaemia?
Lots of lymphocytes >5 x 10 9/ l
Splenomegaly lymphadenopathy
staged according to binet system
CLL treatment indicated for marrow failure (cytopenias)?
if p53 wild type: chemo-immunotherapy regime- fludarabine, cyclophosphamide rituximab (anti-CD20 MAB)
if not fit then bendamustine/rituximab or chlorambucil/obinutzumab
if p53 deleted or mutated or relapsed then ibrutinib
venetoclax
idelalisib PI3K inhibitor (b cell receptor signalling protein)
if CLL complicated by AIHA or ITP then steroids prednisolone
LDH is a good example of?
cell turnover
left shift of blood film?
more myelocytes, erythroblast (nucleated rbc) teardrop cells
high b12
primary myelofibrosis?
jak2 mutation - signalling cells
v617- base substitution
myeloproliferative disorders?
thrombocytosis, polycythaemia vera and myelofibrosis
activation of erythropoietin signal transduction via?
JAK 2 tyrosine kinase
