Case 9- symptoms and treatment of mood disorders Flashcards
Symptoms of depression
- Emotional symptoms- sadness, lack of interest, feeling of guilt and suicidal thoughts.
- Physical symptoms- lack of energy, decreased concentration, change in appetite, change in sleep and change in psychomotor skills. Mostly psychomotor retardation
- Associated symptoms- excessive worry over physical health, pain (chronic pain), anxiety or phobias, brooding, obsessive rumination (worrying if you have turned off the stove or contamination) and irritability
DSM
Produced by the American psychiatric association. Is used most commonly in research. NICE advices DSM-5 for diagnosis. Objective with symptom count
ICD
Produced by WHO is used more commonly in diagnosis. Is based on description of symptoms without symptom count, depression is an exception,
Criteria for an episode of depression DSM-5
5 or more of the following symptoms over a two week period, must have one of the first two symptoms
- Depressed mood
- Reduced interest or pleasure in all activities
- Weight loss, decreased or increased appetite.
- Insomnia or hypersomnia
- Psychomotor agitation or retardation
- Fatigue or loss of energy
- Feelings of worthlessness or inappropriate guilt
- Diminished ability to think or concentrate
- Recurrent thoughts of death or suicide
icd-11 criteria for an episode of depression
ICD-11 is the same as DSM-5 but adds another symptom, feelings of hopelessness. In ICD-10 depression was defined as mild if you had just 4 of the symptoms, moderate with 5 or 6 and severe with over 7. You therefore need less symptoms in ICD-10 to be diagnosed with depression compared to the DSM-5. Using this criteria there are 4-5 times the number of people with depression.
Side effects for antidepressants
Hyponatraemia, Suicidal behaviour, Serotonin syndrome.
Side effects for antidepressants- Hyponatraemia
Usually in the elderly, more frequent in SSRI’s. The patient will appear drowsy and confused with convulsions.
Side effects for antidepressants- suicidal behaviour
Children, young adults and people with a history of suicidal behaviour are most at risk. Patients should be monitored especially at the start of treatment and if the dose changes
Side effects- Serotonin syndrome
Uncommon drug reaction caused by excessive central and peripheral serotonergic activity. Severe toxicity usually occurs with a combination of serotonergic drugs, one of which is generally an MAOI. Symptoms:
• Neuromuscular hyperactivity- tremors, hyperreflexia, rigidity
• Autonomic dysfunction- tachycardia, blood pressure change, shivering, hyperthermia, diarrhoea
• Altered mental state
How to treat Serotonin syndrome
Supportive care and remove the serotonergic medication
Examples of Tricyclic antidepressants
Imipramine, amitriptyline and clomipramine
Mechanism of action of TCA’s
They block the uptake of amines by nerve terminals. They do this by competing for the binding site of the amine transporter, this inhibits noradrenaline and 5-HT uptake.
Two types of TCA’s
TCA’s can have sedating properties or not. Agitated and anxious patients respond best to the sedative compounds. Withdrawn and apathetic patients benefit from the less sedating drugs. TCA’s are widely used despite the risk.
Pharmacokinetics of TCA’s
Once daily administration usually at night. They have a long half-life and are orally rapidly absorbed. They have a very large volume of distribution and low rates of elimination due to plasma protein and tissue binding.
Response to TCA’s
10-20% of patients don’t respond to drug treatment but could be due to inadequate dosage. They have a high risk of toxic effects, Haemodialysis is ineffective at increasing drug elimination if there is an overdose
TCA metabolism
TCA’s undergo Liver metabolism via N-demethylation and hydroxylation producing active metabolites and the plasma concentration of metabolites is comparable to parent drug. There is wide variation in metabolism between individuals. Inactivation is by glucuronide conjugation of the hydroxylated metabolites and is excreted in the urine.
Risks of TCA’s
Half life is longer in elderly patients so low doses should be used initially.
TCA’s have a narrow therapeutic window.
TCA’s are more likely to be discontinued because of side-effects. There is a significant risk of toxicity in over dosage (cardiotoxicity).
TCA side effects
Sedation (acts as a Histamine H1 antagonist), postural hypotension (it is an Alpha 1 antagonist), dry mouth, blurred vision and constipation (muscarinic block).
TCA drug interaction
Alcohol, anaesthetics, hypotensive drugs and NSAIDS. Should not be given with monoamine oxidase inhibitors
Examples of Monoamine-oxidase inhibitors
Phenelzine, tranylcypromine, isocarboxazid, moclobemide
Pharmacokinetics of Monoamine-oxidase inhibitors
Blocks the action of monoamine oxidase enzymes which break down neurotransmitters
When to prescribe MAOI
They are used less frequently due to adverse effects and interactions but may be prescribed when TCA’S are unsuccesful. Phobic patients and depressed patients with atypical hypochondriacal disorder may respond better to MAOI’s. Moclobemide may used for major depression and social phobia. Used in patents who don’t respond to other antidepressants
Risks of MAOI
If stopping a MAOI other antidepressant treatment should not be started for 2 weeks due to lag effect of the drug (washout period)