Cardiovascular System Pt.1 Flashcards

1
Q

Cardiovascular system is made up of…

A

Heart, blood vessels, & Blood
[heart pumps blood into blood vessels throughout the body]

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2
Q

Heart
(Shape and location)

A

🔸️cone-shaped organ
🔸️located slightly to the left side in the thoracic cavity
(in mediastinum)
🔸️rests on the diaphragm
🔸️Apex

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3
Q

Apex of the heart is…

A

🔸️Inferior aspect
🔸️The point of the heart
🔸️Left ventricle

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4
Q

What is mediastinum?

A

a central compartment in the thoracic cavity that houses various organs and structures.

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5
Q

Chambers of the heart are?

A

RA (right atrium) superior
LA (left atrium) superior
RV (right ventricle) inferior
LV (left ventricle) inferior

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6
Q

Atrioventricular sulcus

A
  • external indentation between the atria and ventricles
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7
Q

Interventricular sulcus

A
  • external depression between RV and LV
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8
Q

Veins

A
  • carry blood to heart
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9
Q

Arteries

A

carry blood away from the heart

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10
Q

Great vessels
(Definition)

A

main veins and arteries that bring blood to and from heart

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11
Q

What are the 5 greater vessels?

A

🔸️SVC -Superior Vena Cava
🔸️IVC -Inferior vena Cava
🔸️pulmonary V (veins)
🔸️pulmonary A (artery)
🔸️aorta

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12
Q

SVC -Superior Vena Cava

A

Carries deoxygenated blood from the upper body to the right atrium

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13
Q

Inferior vena cava:

A

Carries deoxygenated blood from the lower body to the right atrium

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14
Q

Pulmonary artery:

A

Carries deoxygenated blood from the right ventricle to the lungs

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15
Q

Pulmonary veins:

A

Carry oxygenated blood from the lungs to the left atrium

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16
Q

Aorta:

A

The largest artery in the body, carrying oxygenated blood from the left ventricle to the rest of the body

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17
Q

Pulmonary circuit:

A

Right side of heart (pulmonary pump) pumps blood to lungs

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18
Q

Pulmonary arteries

A

deliver oxygen-poor (deoxygenated) blood to lungs

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19
Q

Gas exchange

A

between alveoli and pulmonary capillaries

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20
Q

Alveoli

A

tiny, balloon-shaped air sacs located at the end of the bronchioles in the lungs

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21
Q

pulmonary capillaries

A

tiny blood vessels located in the lungs that facilitate gas exchange between the bloodstream and the alveoli (air sacs).

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22
Q

Pulmonary veins

A

deliver oxygen-rich (oxygenated) blood to the left side of the heart from the lungs

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23
Q

Systemic Circuit: What are the 4 things.

A

Systemic pump
Systemic arteries
Gas exchange
Systemic veins

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24
Q

Systemic pump

A

(left side of heart)
-receives oxygenated blood from pulmonary veins and pumps it to rest of body

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25
Q

Systemic arteries

A

pump oxygen-rich (oxygenated) blood to the body (not lungs)

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26
Q

Gas exchange in the systemic circuit happens?

A

at systemic capillaries

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27
Q

Systemic veins return

A

Oxygen-poor (deoxygenated) blood to RA

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28
Q

Pulmonary circuit is low or high pressure circuit? And pumps blood where?

A

-low-pressure circuit
pumps blood only to lungs

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29
Q

Systemic circuit is low or high pressure circuit? And pumps blood where?

A

high-pressure circuit
pumps blood to rest of body

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30
Q

FUNCTIONS OF THE HEART

A

🔸️maintain BP (blood pressure)
🔸️Atria produce hormone: atrial natriuretic peptide (ANP)

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31
Q

Rate & force (heart function)

A

contraction influence BP and blood flow to organs

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32
Q

Atria produce hormone?
And what does it do?

A

🔸️atrial natriuretic peptide (ANP)
🔸️ ANP lowers BP by decreasing Na+(sodium) retention in kidneys →decr. osmotic H2O reabsorption

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33
Q

Pericardium

A

membrane surrounding heart

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34
Q

The 4 types of pericardium that surround the heart are…

A

Fibrous pericardium
Serous pericardium
Parietal pericardium
Visceral pericardium

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35
Q

Fibrous pericardium

A

outermost layer

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36
Q

Serous pericardium produces?

A

produces serous fluid

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37
Q

Parietal pericardium

A

Lines the pericardial cavity

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38
Q

Visceral pericardium

A

aka epicardium
Surface of heart

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39
Q

Pericardial cavity has what kind of fluid and what does this fluid do?

A

🔸️contains serous fluid (pericardial fluid)
🔸️acts as a lubricant, decreasing friction.

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40
Q

HEART WALL is made up of…

A
  1. Epicardium
  2. Myocardium
  3. Endocardium
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41
Q

Epicardium

A

🔸️outmost layer (surface of the heart)🔸️Also known as visceral pericardium

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42
Q

Myocardium

A

(most of the tissue in the heart)
🔸️middle muscle layer
[What type of muscle??]
Cardiac muscle (most of heart)
🔸️fibrous skeleton (dense irregular collagenous CT)

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43
Q

Endocardium

A

innermost endothelial layer

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44
Q

Myocardium has what type of muscle?

A

Cardiac muscle (most of heart)

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45
Q

Cardiac muscle is made up of?

A

fibrous skeleton (dense irregular collagenous CT)

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46
Q

CORONARY CIRCULATION

A

Coronary vessels (supply heart wall):
Branch off ascending aorta:
1. Right Coronary artery
2. left coronary artery

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47
Q

Right Coronary artery

A

→ post. interventricular (post. descending a.)
→ marginal branch

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48
Q

left coronary artery

A

🔸️circumflex branch
🔸️ant. interventricular
🔸️LAD (left ant. descending)

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49
Q

What are the 3 coronary veins?

A

Great cardiac vein
Small cardiac vein
Middle cardiac vein

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50
Q

Heart consists of four chambers:

A

RA (right atrium) superior
LA (left atrium) superior
RV (right ventricle) inferior
LV (left ventricle) inferior

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51
Q

RA (right atrium) superior & LA (left atrium) superior
What do the do?

A
  • 2 Atria
    -receive blood from veins
  • pump through atrioventricular (AV) valves into ventricles
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52
Q

RV (right ventricle) inferior & LV (left ventricle) inferior do what?

A
  • 2 Ventricles
    -ejects blood into arteries
  • carry blood through systemic or pulmonary circuit
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53
Q

(CAD)
What is it?

A

🔸️Coronary artery disease
🔸️buildup of plagues (fatty material) in coronary arteries
🔸️decreases blood flow to myocardium →myocardial ischemia
🔸️leading cause of death worldwide

54
Q

Coronary artery disease (CAD)
Symptoms:

A

-Symptoms: angina pectoris (chest pains)

55
Q

myocardial ischemia
What is it?

A

A condition caused by decreased blood flow to myocardium

56
Q

(MI) or heart attack

A

🔸️Myocardial infarction
🔸️The most dangerous potential consequence of CAD
🔸️Occurs when plaques in coronary arteries rupture
🔸️Clot forms → myocardial tissue infarct (dead tissue)

57
Q

Myocardial infarction (MI) or heart attack
Symptoms:

A

🔸️Symptoms include
chest pain radiating to left arm shortness of breath,
sweating,
anxiety,
and nausea and/or vomiting
🔸️Women may present with back, Jaw, or arm pain instead

58
Q

Myocardial infarction (MI) or heart attack
Risks and after effects

A

Risk factors include
smoking,
incr. BP,
poorly controlled diabetes,
high levels of certain lipids,
obesity

59
Q

Angiography

A

diagnostic test for CAD

60
Q

Myocardial infarction (MI) or heart attack
Treatments

A

🔸️modify Lifestyle
🔸️medications
🔸️then invasive treatments

61
Q

Coronary angioplasty

A

balloon is inflated in blocked artery, and Stent is inserted

62
Q

Coronary artery bypass grafting (CABG)

A
  • other vessels are grafted onto diseased coronary artery to bypass blockage
63
Q

Pectinate muscles -

A

muscular ridges inside RA

64
Q

Interatrial septum -

A

wall between RA & LA

65
Q

Fossa ovalis -

A

indentation in interatrial septum; remnant of opening from fetal circulation

66
Q

Trabeculae carneae -

A

ridged surface in ventricles “beams of flesh”

67
Q

ELECTROPHYSIOLOGY

A

🔸️Cardiac muscle exhibits autorhythmicity
🔸️Cardiac muscle cells contract in response to electrical excitation in the form of APs
🔸️Cardiac muscle cells do not require stimulation from the nervous system to generate APS
*They get the AP from themselves

68
Q

Pacemaker Cells

A
  • specialized cardiac muscle cells (=1% of cardiac muscle cells)
  • coordinate cardiac electrical activity
  • rhythmically and spontaneously generate APS to other types of cardiac muscle cells (contractile cells = 99% of cardiac muscle)
69
Q

Cardiac muscle cells
Are made of?

A

🔸️Striated (Bands of light & dark)
🔸️branched
🔸️uninucleated
🔸️intercalated discs
🔸️generate tension through sliding-filament mech.
Ex. of Structure-Function Core Principle

70
Q

Cardiac conduction system

A
  • Pacemaker cells undergo rhythmic, spontaneous depolarizations → APs
71
Q

Functional syncytium

A
  • Permits heart to contract as a unit and produce a coordinated heart beat
72
Q

Plateau phase

A

lengthens cardiac AP slow’s HR providing time required for heart to fill with blood;
also increases the strength of the heart’s contraction

73
Q

Refractory period

A

🔸️in cardiac muscle cells is so long that cells can not maintain a sustained contraction
🔸️allows heart to relax & ventricles to refill before cardiac muscle cells are stimulated to contract again

74
Q

Sinoatrial node (SA node)

A

🔸️Main pacemaker
🔸️ located in upper RA
🔸️60 to 100 bpm influenced by SNS & PSN

75
Q

Atrioventricular node (AV node)

A

🔸️ located near tricuspid valve

🔸️40 bpm
🔸️AV node delay

76
Q

Purkinje fiber system

A

🔸️Atrioventricular bundle (Av bundle
🔸️Right and left bundle branch
🔸️Purkinje fibers
- located in ventricular walls

77
Q

AV node delay

A

🔸️allows atria to depolarize (and contract) before ventricles, giving ventricles time to fill with blood
🔸️also helps to prevent current from flowing backward from Av bundle into AV node and atria

78
Q

Sinus rhythms =

A

electrical rhythms generated & maintained by SA node

79
Q

Electrocardiogram (ECG)- EKG (rest of world)

A

🔸️graph of electrical activity in cardiac muscle cells over time
-🔸️electrodes placed on patient’s skin (6 on chest, 2 on each leg)
🔸️detects disturbance in electrical rhythm = dysrhythmia or arrhythmia (= no rhythm)

80
Q

arrhythmia

A

(= no rhythm)

81
Q

ECG represents

A
  • depolarization or repolarization of parts of heart
82
Q

P wave represents

A

depolarization of atria

83
Q

QRS complex represents

A

🔸️ventricular depolarization

84
Q

T wave represents

A

ventricular repolarization

85
Q

Atrial fibrillation

A

🔸️generally not life threatening
🔸️atrial contraction isn’t necessary for ventricular filling
🔸️ECG tracing “irregularly irregular” rhythm (one that has no discernible pattern) that lacks P waves

86
Q

Ventricular fibrillation (v-fib)

A

🔸️immediately life-threatening
🔸️ECG exhibits chaotic activity

87
Q

defibrillation

A

🔸️ (an electric shock to heart) depolarizes all ventricular muscle cells simultaneously
🔸️SA node will resume pacing heart after shock is delivered (ideally)

88
Q

“Flat-lining” is also known as…

89
Q

defibrillation is not used for asystole because…

A

heart is not fibrillating and there is no electrical activity to reset

90
Q

asystole is treated

A

with CPR and pharmacological agents that stimulate heart such as atropine and Epi

91
Q

Mechanical physiology

A
  • actual processes by which blood fills and is pumped out of chambers
92
Q

Heartbeat

A

Cardiac muscle cells contract as a unit to produce coordinated contractions

93
Q

Cardiac cycle

A
  • sequence of events that take place from one heartbeat to next (systole followed diastole for each chamber)
94
Q

Gradients Core Principle

A

as ventricles contract and relax, pressure in chambers changes, causing blood to push on valves and open or close them:
Ventricular systole
Ventricular diastole

95
Q

Ventricular systole
(contraction phase)

A
  • Both of AV valves are forced shut by blood pushing against them
  • Both of semilunar valves are forced open by outgoing blood
96
Q

Ventricular diastole
(relaxation phase) -

A

Press. In ventricles falls below those in atria and in pulmonary trunk and aorta
→ forces AV valves open, allowing blood to drain from atria into relaxed ventricles

97
Q

Stethoscope

A
  • used to listen to (auscultate) rhythmic heart sounds:
    🔸️S1 (“lub”) = AV valves close
    🔸️S2 (“dub”)= Semilunar valves close
98
Q

S1 (“lub”)

A

= AV valves close

99
Q

S2 (“dub”)=

A

Semilunar valves close

100
Q

Heart rate (HR) is how many bpm?

A

60-80 cardiac cycles or bpm

101
Q

Stroke volume

A

70 ml/beat (amt. of blood ejected from each ventricle in a beat)

102
Q

What does (CO) stand for?

A

Cardiac output
vol. of blood pumped into pulmonary & systemic circuits in 1 min. (ml/min.)

103
Q

DETERMINATION OF CARDIAC OUTPUT (formula)

A

🔸️heart rate x stroke volume= C.O.
🔸️72 beats/min x 70 ml/beat = 5040 ml/min = 5 liters/min (C.O.)

104
Q

Resting C.O. is how many liters/ min? And how many goes through the circuits?

A
  • averages about 5 liters/min;
    🔸️RV pumps 5 liters into pulmonary circuit
    🔸️LV pumps same amt. to systemic circuit
105
Q

In myocardial infarction, dead cells are replaced with

A

🔸️ scar tissue

106
Q

Death of part of myocardium increases the

A

workload for remaining heart muscles

107
Q

Atrial repolarization is masked by…

A

QRS complex

108
Q

The two AV valves are?

A

the tricuspid valve and the mitral valve.

109
Q

The two Semilunar valves are?

A

Pulmonary valve and aortic valve

110
Q

FACTORS THAT INFLUENCE STROKE VOLUME
Frank-Starling law

A

🔸️Increased ventricular muscle cells stretch, leads to forceful contraction
🔸️Ensures that vol. of blood discharged from heart is equal to vol. that enters it
🔸️Important during exercise, when C.O. must increase to meet the body’s needs

111
Q

FACTORS THAT INFLUENCE HEART RATE

A

HR due to rate at which SA node generates APS

112
Q

chronotropic agents

A

Factors that influence rate at which SA node depolarizes

113
Q

Positive chronotropic agents

A

SNS, some hormones, increased body temp.

114
Q

Negative chronotropic agents

A

PSN, decreased body temperature

115
Q

REGULATION OF CARDIAC OUTPUT

A

Heart is autorhythmic but still requires regulation to ensure C.O. meets body’s needs at all times
Regulated by nervous (ANS) and endocrine systems

116
Q

SNS (NEpi) ↑HR then it

A

↑ force of contraction

117
Q

PSN (ACH) ⬇️ HR then

A

⬇️ force of contraction

118
Q

Hormonal regulation

A

Adrenal medulla

119
Q

Adrenal medulla

A

affected by SNS → Epi and NEpi
-thyroid hormone and glucagon

120
Q

Blood volume

A
  • Aldosterone and antidiuretic
121
Q

Aldosterone and antidiuretic

A

hormone increase blood vol. incr. C.O. - ANP decreases blood vol. reduces C.O.

122
Q

Other factors that influence cardiac output:

A

-[Electrolyte] in ECF
-Body temperature
- Age
- Exercise

123
Q

Body temperature

A

SA node fires more rapidly at higher body temp. and more slowly at lower body temp.

124
Q

Heart failure

A

Heart failure (formerly CHF) = any condition that reduces heart’s ability to pump effectively

125
Q

myocardial ischemia and/or M.I

A

valvular heart diseases, any disease of heart muscle (cardiomyopathy), and electrolyte imbalances

126
Q

Heart failure →

A

decreased SV → reduced C.O.
Signs and symptoms of heart failure depend on type of heart failure and side of heart that is affected

128
Q

LV failure

A

blood often backs up within pulmonary circuit; known as pulmonary congestion → pulmonary edema

129
Q

Both RV and LV failure

A

peripheral edema, in which blood backs up in systemic capillaries (systemic congestion)

130
Q

Symptoms of heart failure

A

Swelling in legs and feet
- Peripheral edema exacerbated by kidneys retain excess fluid

131
Q

Treatment f or heart failure

A
  • increase cardiac output
  • Lifestyle modifications -weight loss and mild exercise, dietary sodium and fluid restrictions
  • Drug therapy
  • Heart transplant and/or pacemaker