Cardiovascular system: Lecture 9 -Cardiovascular responses to stress Flashcards

1
Q

How do we calciulate cardiac output?

A

cardiac output = heart rate x stroke volume

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2
Q

How do we calculate mean systemic arterial pressure? (blood pressure)

A

mean systemic arterial pressure = cardiac output x total peripheral resistance

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3
Q

What is total peripheral resistance?

A

the amount of resistance to blood flow present in the vascular system of the body

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4
Q

Intrinsic cardiac regulation: Draw the Frank-starling curve

A
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5
Q

What is preload?

A

What you put into the heart - best measured by end diastolic volume (amount of blood in the ventricles before the ventricles contract)

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6
Q

How do we measure end diastolic volume?

A

An echo cardiogram

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7
Q

What is the relationship between pre load and stroke volume?

A
  • increase in preload increases stroke volume
  • high levels of preload eventually lead to decrease in stroke volume
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8
Q

Give 8 ways we can increase preload

A

Increasing preload is achieved by increasing stroke volume by:

  • increase circulating volume (e.g giving fluids)
  • increase central venous pressure
  • increase respiratory pump
  • decrease venous compliance (stiffer veins = reduced resistance = increased SV)
  • increase atrial filling or contraction
  • increase ventricular compliance (greater force of contraction = greater SV)
  • decrease heart rate (prolongs diastole)
  • increase aortic and pulmonary pressure
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9
Q

What is central venous pressure?

A

blood pressure in the vena cava

CVP reflects the amount of blood returning to the heart and the ability of the heart to pump the blood back into the arterial system.

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10
Q

What is the Bowditch effect?

A
  • increase in heart rate increases force of contraction and vise versa
  • High heart rate eventually leads to decreased force of contraction
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11
Q

Is the bowditch effect related to Frank-Sterling?

A

No they’re independent as length of muscle not affected in the Bowditch effect

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12
Q

What happens to your contractility if you suffer from heart disease?

A

It decreases

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13
Q

Whats the relationship between peak contractibility and left ventricular ejection fraction? (%)

A
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14
Q

What is venous return?

A

Flow of blood back to the heart

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15
Q

What is the Bainbridge reflex?

A
  • increased venous return
  • baroreceptors in the atria detect increased stretch
  • heart rate increased via sympathetic stimulation to SAN
  • involved in sinus arrhythmia
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16
Q

What is sinus arrhythmia?

A

Irregular heartbeat thats either too fast or too slow

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17
Q

what is the bainbridge reflex antagonistic to?

A

the carotid baroreceptor response

18
Q

What are the 3 mechanisms of intrinsic cardiac regulation?

A
  1. frank sterling
  2. Bowditch effect
  3. Bainbridge reflex
19
Q

What are the two body parts involved in the sympathetic nervous system but not the parasympathetic nervous system?

A

Kidneys and adrenals

20
Q

What are the 4 direct cardiac sympathetic actions to increase heart rate?

A
  1. Positive chronotropy - affects the SA node
  2. Positive dromotropy - affects the AV node so speeds up conduction
  3. Positive Inotrophy - increases contraction of ventricles and atria
  4. Positive Lusitrophy - relaxation of ventricles and atria
21
Q

what are two systemic sympathetic actions to increase heart rate?

A
  1. Activation of Renin-Angiotensin-Aldosterone system (RAAS)
  2. Suprarenal stimulation (Catecholamines e.g adrenaline)
22
Q

What is the relationship between inotropy/preload and chronotropy and cardiac performance?

A

dobutamine - drugs mimic the sympathetic system so can increase hwart rate

23
Q

Explain how the Renin Angiotension Aldosterone System works (RAAS)

A
  1. liver produces angiotensinogen
  2. Renin (produced in kidney) coverts angiotensinogen into angiotensin I
  3. ACE (angiotensin converting enzyme) converts Angiotensin I into Angiotensin II
  4. Angiotensin II acts on the adrenal galdn
  5. Adrenal gland secretes Aldosterone which causes water retention
  6. Blood pressure increases!
24
Q

What are the actions of angiotensin II in RAAS?

A
  • Vasoconstriction
  • increased Na+ and H2O retention
25
Q

What is the action of aldosterone in RAAS?

A

-Increased Na+ and H2O retention

26
Q

What is the action of vasopressin in RAAS?

A

Antidiuretic hormone

Promotes H2O retention

27
Q

Why does vasoconstriction increase blood pressure?

A

Increases total peripheral resistance

(cardiac output x total peripheral resistance = mean systemic arterial pressure)

28
Q

What are catecholamines?

A

Vasocontricting compounds released into blood

29
Q

Give 3 parasympatheitc actions that decrease heart rate?

A
  1. Negative chronotrophy - decreased heart rate (SAN)
  2. Negative dromotrophy - decreased AV conduction
  3. Negative inotrophy - decreased atrial contractility

Ventricular contractiity and RAAS have no significant parasympathetic action

30
Q

How is the ANS (autonomic nervous system) regulated?

A
  • Baroreceptors
  • local
  • ‘higher’ e.g fear
31
Q

Where are baroreceptors located in th heart?

A

Carotid sinuses, aortic arch

32
Q

How would decreased arterial pressure effect sympathetic and parasympathetic tone?

A
  • decreased arterial pressure
  • decreased baroreceptor firing of impulses
  • increases sympathetic response
  • decreases parasympathetic response
33
Q

How would increased arterial pressure effect sympathetic and parasympathetic tone?

A
  • increased firing
  • decreases sympathetic tone
  • increases parasympathetic tone
34
Q

Why would a patient who has been bleeding and lost a lot of blood have a decreased preload?

A

loosing blood means theres reduced central venous pressure (less blood going into heart) so preload decreases

35
Q

Give two overall summaries of initial response mechanisms to blood loss

A

slide 53 and 54

36
Q

What are the signs of haemorragic shock?

A
  • low BP e.g 90/50
  • large pulse/ high HR e.g 130
  • confused- reduced BP meaning less 02 getting to the brain
  • poor urine output: reduced renal perfusion
  • tachypnoeic (abnormally rapid breathing)
37
Q

What is the initial intervention for blood loss and why?

A

Giving IV/ blood transfusion

This will increase central venous pressure and therefore preload and therefore stroke volume

38
Q

When might this treatment not work?

A

too much fluid is given

central venous pressure becomes too great

preload increases too much

cardiac outut actually falls

39
Q

How do you treat fluid overload?

A

Diuretics e.g furosemide

40
Q

Which test is the most comprehensive in evaluating functional aspects of the heart and lungs and physical fitness?

A

cardiopulmonary exercise testing

41
Q

What measurements are taken in a cardiopulmonary exercise test?

A
  • Oxygen consumption at rest and during exercise
  • The anaerobic threshold - the level of exercise when the exercising muscles begin to have anaerobic metabolism and release copious amounts of lactic acid;
  • Haemodynamic variables including HR, BP, CO, from which we can calculate other parameters such as CPO, vascular resistance, etc.

VO2 max is the value we used to know how bad someones cardiac situation is