Cardiovascular/Pulmonary System Flashcards
Individuals with a total serum cholesterol >____mg/dl increases the relative risk of developing CAD
200
What is the established risk age threshold for males and females for developing CAD?
55 years females, 45 years males, males more likely to have CAD
Individuals with HD levels <____mg/dl increases the relative risk of developing CAD
40
Is pleural effusion restrictive or obstructive?
Restrictive: total lung volume decreased, so FEV1/FVC most likely won’t be affected.
If pt’s exercise program is for weight loss what is the weekly minimum calorie expenditure?
2000 kcal/week
Which artery supplies the R atrium?
Sinus node
Which artery supplies the R ventricle
R marginal
Which artery supplies the inferior walls of both ventricles and IV septum?
Post. descending artry
What does the circumflex artery supply?
L atrium, L ventricle
Which artery supplies the anterior portion of the IV septum?
L anterior descending artery
How does the sympathetic N.S. influence the heart?
stimulate chambers to beat faster (chonotropic), and increase the force of the contraction (inotropic effect)
How does the parasympathetic influence the heart?
Slow the HR on by acting on SA node
Bainbridge reflex
increase in venous return sends vagal signals to medulla which inhibits PS activity, resulting in increased HR
What happens when arterial PPO2 of less than 50mmHg or conditions of acidosis?
Stimulates respiratory centers to increase depth and rate of ventilation. Then the para slows down HR and myocardial contractility. If persistent hypoxia, CNS will be directly stimulated and will increase sympathetic activity.
Which white blood cells participate in allergic responses?
Eosinophils (also kill parasites and destroy cancer cells) and basophils
Which white blood cells ingest damaged cells?
Monocytes
Which white blood cells ingest bacteria?
neutrophils
Which ribs articulate with only 1 vertebra?
1, 10, 11, 12
The R superior lobar bronchus divides into which 3 segmental bronchi
apical, anterior, and posterior
The R middle lobar bronchus divides into which 2 segmental?
medial and lateral
The R inferior lobar bronchus divides into which 5 segmental bronchi
superior, medial basal, anterior basal, lateral bases, and posterior basal
The anterobasil L segmental corresponds to which 2 R segmental?
medial basal, lateral basal
the apical posterior l L segmental corresponds to which 2 R segmental?
posterior and apical
Medications to treat dilated cardiomyopathy
ACE inhibitors, beta blockers, digoxin, diuretics.
Medications to treat hypertrophic cardiomyopathy
Medications to slow the HR and stabilize rhythm, e.g. Lopressor and calcium channel blockers
Medications to treat restrictive cardiomyopathy?
diuretics, antihypertensives, and antiarrhythmics.
What is the tetralogy of Fallot?
1) ventricular septal defect
2) pulmonary stenosis
3) R ventricular hypertrophy
4) Aorta overriding the ventricular septal defect
What is Cor Pulmonale
Hypertrophy of the R ventricle, from chronic R pulmonary circa. resistance.
Arterial hypertension in adults DP and SP, what is it for children?
Adults: DP >/=140, SP >/=90
Children: > than the 95th percentile
Which S sound is an early heart sound of hypertension complications?
S4
Sever HTN DP value
> 120 bpm, can cause confusion, cortical blindness, hemiparesis, seizures
Stage 1 vs Stage 2 hypertension
1: 140-159/90-99
2: >/=160/>/=100
Endocarditis vs Myocarditis vs Pericarditis: location, etiology, signs/symptoms
Endo: bacteria, can damage heart valves, fever/chills, murmur, SOB, skin petechiae.
Myo: viral or bacterial, arrhythmias, angina, SOB, fever, fatigue
Peri: viral, bacterial, fungal, angina,SOB, dry cough, anxiety, fatigue, fever. The amount of fluid between the 2 layers increases (pericardial effusion) If severe cardiac tamponade (pressure prevents heart from properly filling with blood, sharp drop in BP)
Supervised exercise training for PAD recommendations
30-45 minutes, at least 3x/wk, at least 12 weeks.
Rheumatic Fever
From untreated strep throat (Strep A)
Etiology of valvular heart disease
congenital, calcific degeneration, infective endocarditis, CAD, MI, and rheumatic fever
Acute Respiratory Distress Syndrome: etiology, causes, fatality rate
Fluid leaks from the smaller vessels in the lungs, into the alveoli. Fatal in 25-40%. Caused by sepsis, HF, severe pneumonia, serious head/chest injury, drug overdose (e.g. heroin), shock, near drowning, adverse reaction to cancer drugs, prolonged use of large volumes of supplemental O2
Bronchiectasis vs Bronchitis
Ectasis: obstructive, abnormal dilation of the bronchus, due to injury of the airways or lung infection
Itis: Inflammation of the bronchi, productive cough for 3 months over the course of 2 consecutive years. Cough worse in morning and in damp weather
What are the 2 main obstructive lung disorders? What happens to lung capacity?
Bronquitis and emphysema. Increase in total lung capacity, increase in residual volume.
Signs and symptoms of acute pulmonary edema, call 911?
It is life threatening! Extreme SOB, bubbly wheezing, gasping, frothy sputum, cyanosis, rapid irregular pulse, hypotension
Pulmonary fibrosis: restrictive or obstructive, type of cough
Restrictive, non-productive cough
RLDs: etiology
Abnormal lung parenchyma, eg atelectasis, pneumonia, pulmonary fibrosis, pulmonary edema, ARDS, pleural effusion-fibrosis, pneumothorax, hemothorax
Arterial Blood Gas, mean range of adult normal values, conventional order
In this order pH: 7.4 PaCO2: 40 (35-45) at sea level PaO2: 97 at sea level HCO3-: 24 (22-26) mEq/L eg. 7.4/40/97/24
Eucapnia, hypercapnia, hypo
normal level of PaCo2, to much, too little
Mild hypoxemia value
PaO2 of 60-79 mmHG, SPO2 90-95%, if no shift in the oxyhemoglobin curve
Moderate hypoxemia
40-59, SPO2 60-80%, if no shift in the oxyhemoglobin curve
Severe Hypoxemia
<60%, if no shift in the oxyhemoglobin curve
Hypoxia
low level of O2 in the tissue despite adequate tissue perfusion
Which tests specific for MI
CK-MB, peaks at 12-24 hours following MI, declines over 2-3 days
Cardiac Troponin-I, remains elevated for 5-7 days
PaCO2 > 45 and pH < 7.4 indicates what?
respiratory acidosis
PaCO2 > 45 and pH > 7.4 indicates what?
retention of CO2 to compensate for metabolic alkalosis
PaCO2 < 35 and pH > 7.4 indicates what?
respiratory alkalosis
PaCO2 < 35 and pH < 7.4 indicates what?
retention of CO2 to compensate for metabolic acidosis
HCO3- < 22 and pH < 7.4 indicates what?
metabolic acidosis
HCO3- < 22 and pH > 7.4 indicates what?
Renal compensation for respiratory alkalosis
HCO3- > 26 and pH > 7.4 indicates what?
metabolic alkalosis
HCO3- > 26 and pH < 7.4 indicates what?
renal compensation for respiratory alkalosis
Conventional and SI hematology value for erythrocytes:
Males: 4.3-5.6 x 10^6/ml (conventional) or 10^12/L
Females: 4.0-5.2
Conventional and SI hematology value for total leukocytes:
3.54-9.0 x 10^3/mm^3 or 10^9/L
Conventional and SI hematology value for neutraphils
.4-.7 or 40-70%
Conventional and SI hematology value for lymphocytes
.2-.5 or %
Conventional and SI hematology value for monocytes
.04-.08 or %
Conventional and SI hematology value for eosinophils
.0-.06 or %
Basophils
.0-.2 or %
Conventional and SI hematology value for platelet count
165-415 x 10^3/mm^3 or 10^9/L
Conventional and SI hematology value for PTT
26.3-39.4 sec
Conventional and SI hematology value for hematocrit
Males: .3388-.464 or %
Females: .354-.444 or %
Conventional and SI hematology value for hemoglobin
Males: 13.3-16.3 gm/dL
Females: 12.0-15.8 gm/dL
Conventional and SI hematology value for borderline total serum cholesterol
200-239 mg/dL or 5.17-6.20mmol/L
Conventional and SI hematology value for borderline LDL and very high LDL
Borderline: 130-159 mg/dL or 3.36-4.12 mmol/L
Very high: >/= 190mg/dl or 4.91 mmol/L
Conventional and SI hematology value for low and high HDL
Low: /= 60mg/dL or 1.55 mmol/L
Conventional and SI hematology value for borderline and very high triglycerides
Borderline: 150-159mg/dL or 1.7-2.25 mmol/L
>/= 500 mg/dL or 5.64 mmol/L
Which clotting time is more sensitive for detecting minor deficiencies? (PTT or PT)
PTT
What is a Holter Monitor?
Ambulatory ECG-worn for 24-48 hours to monitor someone
What is electrophysiologic testing?
using 3-5 catheters inserted into a blood vessel and threaded to the heart, evaluates the rhythm or electrical conduction abnormalities of the heart, to locate abnormal tissue that causes arrhythmias
Swan-Ganz catheter where? measures what?
Pulmonary artery, measures pulmonary artery wedge pressure and L atrial pressure
Thermodilution catheter measures what?
cardiac output
CVP line where? measures what?
vena cava or R atrium, pressure in either
What is myocardial perfusion imaging?
Also known as a radionuclide stress test, injected into blood at rest and at max execs to show how well heart muscle is perfused under these conditions.
What is phonocardiography?
makes a graph of heart sounds, supplements auscultation, improves detection of S3 and S4
Alpha Adrenergic Antagonist Agents: Action Indications Side Effects Implications for PT Examples (all end in " "):
Action: reduces peripheral vascular tone by blocking alpha-1-adrenergic receptors
Indications: hypertension, BPH
Side Effects: dizziness, ortho. hypotension, drowsiness
Implications for PT: careful supine to sit/stand
Examples: “osin”Cardura (doxazosin), Minipress (prazosin), Hytrin (terazosin)
ACE Inhibitor Agents: Action Indications Side Effects Implications for PT Examples (all end in " ")
Action: Suppress the enzyme that converts antiotensin I to II, therefore decreases BP and after-load
Indications: HTN, CHF
Side Effects: hypotension, dizziness, DRY COUGH, HYPERKALEMIA
Implications for PT: Avoid sudden changes in posture and with CHF, avoid rapid increases in physical activity.
Examples (all end in “ “): phil Capoten (captorpril), Vasotec (enalapril), Prinivil (lisinopril), Altace (ramipril)
Angiotensin II Receptor Antagonist Agents: Action Indications Side Effects Implications for PT Examples (all end in " "):
Action: Block II receptors which limits vasoconstriction and limits stimulation of vascular tissue
Indications: HTN, CHF
Side Effects: dizziness, BACK AND LEG PAIN, ANGINA
Implications for PT: Minimal
Examples (all end in “ “): arran Cozaar (losartan), Atacand (candesartan), Diovan (valsartan)
Antiarrhythimic Agents The 4 Classes, and each's action, which class considered most effective?
Indications
Side Effects
Implications for PT
Examples (all end in “ “)
I: Sodium channel blockers, control cardiac excitation and conduction
II: beta blockers, inhibit sympathetic activity
III: prolong repolarization by inhibiting both potassium and sodium channels, most effective.
IV: Calcium channel blockers, depress depolarization and slow conduction through the AV node
Indications: arrhythmias
Side Effects: exacerbation of arrhythmias, hypotension, dizziness
Implications for PT: its should adhere to dosing schedule
Examples (all end in “ “):
I: Quinidine (generic), xylocain (lidocaine)
II: Tenormin (atenolol)
III: Cordarone (amiodarone)
IV: Cardizem (diltiazem”
Anticoagulant Agents: Action Indications Side Effects Implications for PT Examples (all end in " "):
Action: Inhibit platelet aggregation and thrombus formation.
Indications: prevention of embolism
Side Effects: bleeding
Implications for PT: avoid injury
Examples (all end in “ “): Heparin, Coumadin (warfarin), Lovenox (enoxaparin)
Antihyperlipidemia Agents: Action Indications Side Effects Implications for PT Examples (all end in " "):
Action: 5 categories, statins most common, inhibit enzyme action in cholesterol synthesis, and break down LDLs, decrease trig. increase HDL
Indications: hyperlipidemia, atherosclerosis, prevent coronary events in ppl with CAD, diabetes, PVD
Side Effects: headache, GI, MYALGIA, rash
Implications for PT: Exercise good for HDLs
Examples (all end in “ “): Lipitor (atorvastatin) Zocor (simvastatin), Tricor (fenobibrate)
Antithrombotic Agents Action Indications Side Effects Implications for PT Examples (all end in " "):
Action: Inhibit platelet aggregation and clot formation
Indications: post-MI, a-fib, prevent thrombus
Side Effects: bleeding, thrombocytopenia, liver toxicity with use of aspirin, GI
Implications for PT: avoid injury
Examples (all end in “ “): Bayer (aspirin), Plavix (clopidogrel), Persantine (dipyridamole)
Calcium channel blocker agents: Action Indications Side Effects Implications for PT Examples (all end in " ")
Action: Decrease entry of calcium into vascular smooth muscle, causing vasodilation, decreased myocardial contractions, decreased oxygen demands of the heart.
Indications: HTN, angina, arrhythmias, CHF
Side Effects: dizziness, headache, hypotension, PERIPHERAL EDEMA
Implications for PT: HR and BP response to exercise will be blunted
Examples (all end in “ “) Norvasc (amlodapine) Procardia (nifedipine) Calan (verapamil) Cadizem (diltiazem)
3 types of diuretics, and examples of each
Thiazide: Diuril (chlorothiazide)
Loop: Lasix (furosemide)
Potassium-sparing: Dyrenium (triamterene)
Nitrate Agents: Action Indications Side Effects Implications for PT Examples (all end in " ")
Action: decrease ischemia through smooth muscle relaxation and dilation of peripheral vessels
Indications: angina
Side Effects: headache, dizziness, hypotension, REFLEX TACHYCARDIA
Implications for PT: Sublingual administration of nitroglycerin is the preferred method to treat an acute angina attack.
Examples (all end in “ “) Nitrostat (nitroglycerin), Isordil (isosobide dinitrate), Amyl nitrate solution for inhalation.
Positive Ionotropic Agents Action Indications Side Effects Implications for PT Examples (all end in " ")
Action: Increase force and velocity of myocardial contraction, slow HR, and decrease conduction velocity through AV node, and decrease sympathetic NS activation.
Indications: HF, Afib
Side Effects: arrhythmias, GI, dizziness, blurred vision
Implications for PT: Monitor HR during activity, SEEK MD ADVICE FOR HR100
Examples (all end in “ “): Lanoxin (digoxin)
Thrombolytic Agents: Action Indications Side Effects Implications for PT Examples (all end in " ")
Action: Facilitate clot dissolution through conversion of plasminogen to plasmin.
Indications: Acute MI, pulmonary embolism, ischemic stroke, A or V throbosis
Side Effects: intracranial hemorrhage, allergy, arrhythmia
Implications for PT: avoid injury
Examples (all end in “ “): Linlytic (urokinase), Activase (alteplase)
What is amiodarone?
Class III Antiarrhythmic Agent (Cordarone)
What is Lovenox?
Anticoagulant agent (enoxaparin)
What is digoxin?
Positive ionotropic agent (Lanoxin)
What is triamteren?
Potassium sparing diuretic (Dyrenium)
What is dipyridamole?
Antithrombotic agent (Persantine)