Cardiovascular Flashcards
1
Q
diltiazem
A
voltage gated ca channel blocker
2
Q
verapamil
A
voltage gated ca blocker
3
Q
nifedipine
A
voltage gated ca blocker
4
Q
dihydropyridines
A
voltage gated ca blocker
5
Q
thapsigargin
A
SERCA pump blocker
6
Q
what kind of mechanism does IP3 use?
A
Gq
7
Q
dantrolene
A
blocks RyR
8
Q
caffeine
A
blocks RyR
9
Q
what can genetic abnormalities of RyR cause?
A
malignant hyperthermia
10
Q
how many EF hand binding domains in calmodulin
A
4
11
Q
what is the specific target of calmodulin
A
CaM kinase calcium calmodulin kinase
12
Q
digoxin
A
digitalis cardiac glycosides
blocks Na/K ATPase
13
Q
what processes cause contraction of smooth muscle
A
Gq PLC IP3 and Ca
14
Q
what processes cause relaxation of smooth muscle
A
Gs cAMP PK
15
Q
how does NO effect smootth muscle
A
relaxation via guanylyl cyclase
