Cardiovascular Flashcards by Monique Yuan

Q

diltiazem

A

voltage gated ca channel blocker

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Q

verapamil

A

voltage gated ca blocker

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Q

nifedipine

A

voltage gated ca blocker

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Q

dihydropyridines

A

voltage gated ca blocker

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Q

thapsigargin

A

SERCA pump blocker

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Q

what kind of mechanism does IP3 use?

A

Gq

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Q

dantrolene

A

blocks RyR

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Q

caffeine

A

blocks RyR

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Q

what can genetic abnormalities of RyR cause?

A

malignant hyperthermia

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Q

how many EF hand binding domains in calmodulin

A

4

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Q

what is the specific target of calmodulin

A

CaM kinase calcium calmodulin kinase

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Q

digoxin

A

digitalis cardiac glycosides
blocks Na/K ATPase

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Q

what processes cause contraction of smooth muscle

A

Gq PLC IP3 and Ca

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Q

what processes cause relaxation of smooth muscle

A

Gs cAMP PK

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Q

how does NO effect smootth muscle

A

relaxation via guanylyl cyclase

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Q

digoxin

A

Na/K ATPase inhibitor
digitalis cardiac glycoside

Q

how does cAMP cause relaxation of smooth muscle

A

inactivates MLCK by phosphorylating it

Q

how does cGMP cause relaxation of smooth muscle

A

dephosphorylates mysosin-LC