cardio 5 Flashcards
what causes angina
O2 demand is higher than the supply
how does the heart respond to increased O2 demand
coronary dilation
how can you decrease preload with a drug
venodilator
how can you decrease afterload with a drug
arterial vasodilator
what can increase local coronary flow
low o2 tension
high co2 tension
lactate
adenosine
prostacyclin
why is diastole a window for coronary flow
aortic pressure > ventricular
what is coronary perfusion pressure equal to
coronary artery diastolic pressure - LVEDP
what might cause constriction in coronary smooth muscle
alpha receptors
why are coronary dilators not good for angina caused by a plaque
coronary steal
what are the 3 treatment procedures for angina
lower LVEDP (reduce preload)
prolong diastole
reduce work load
what do all anginal drugs do?
REDUCE CARDIAC WORKLOAD
what drugs lower LVEDP`
glyceryl trinitrate (nitroglycerine)
what is the class of drugs that lower LVEDP
venodilators
how does nitroglycerine produce coronary vasodilagtion without coronary steal
collateral vessels
how is nictroglycerine administered for acute attacks
sublingual
