Animal Model 2 Flashcards
What kind of drugs restore behaviours after depression?
tricyclic antidepressants
Which drug is not effective in restoring behaviours? What class does it belong to?
chlorpromazine (neuroleptic/antipsychotic)
What is the main finding of the Porsolt Forced Swim Test?
exposure to uncontrollable aversive events –> decreased motivation to respond –>”learned helplessness”
What was the effect of treating rodents with antidepressants in the Porsolt Forced Swim Test?
increased swimming time
Which anxiolytic increased swimming time in the forced swim test?
buspirone
What was the effect of using fluoxetine in the forced swim test? What class of drug is fluoxetine?
- SSRI
- decreased immobility, increased swimming
What was the effect of using reboxetine in the forced swim test? What class of drug is reboxetine?
- NRI
- decreased immobility, increased climbing
Which drugs were used in the forced swim test to reverse the effects of learned helplessness?
- buspirone
- fluoxetine
- reboxetine
What did the tail suspension test assess? What did it measure?
behavioural despair; measure amt of time spent immobile
What kind of drugs were used to prolong attempts to correct positioning in the tail suspension test?
antidepressants (SSRIs)
What paradigm is the elevated plus maze based on?
rodents would rather be in the enclosed arms
Which anxiolytic drug is used in the elevated plus maze? What class?
LORAZEPAM (benzodiazepine)
Which drug increased anxiety in the elevated plus maze? What class?
YOHIMIBINE (alpha2 agonist)
Which drug caused a greater latency to enter open arms in the elevated plus maze?
yohimbine
What is the vogel conflict test used for?
standard for fast screening the potential anxiolytic properties of drugs