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PMCOL 343 > Animal Model 2 > Flashcards

Animal Model 2 Flashcards

1
Q

What kind of drugs restore behaviours after depression?

A

tricyclic antidepressants

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2
Q

Which drug is not effective in restoring behaviours? What class does it belong to?

A

chlorpromazine (neuroleptic/antipsychotic)

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3
Q

What is the main finding of the Porsolt Forced Swim Test?

A

exposure to uncontrollable aversive events –> decreased motivation to respond –>”learned helplessness”

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4
Q

What was the effect of treating rodents with antidepressants in the Porsolt Forced Swim Test?

A

increased swimming time

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5
Q

Which anxiolytic increased swimming time in the forced swim test?

A

buspirone

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6
Q

What was the effect of using fluoxetine in the forced swim test? What class of drug is fluoxetine?

A
  • SSRI
  • decreased immobility, increased swimming
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7
Q

What was the effect of using reboxetine in the forced swim test? What class of drug is reboxetine?

A
  • NRI
  • decreased immobility, increased climbing
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8
Q

Which drugs were used in the forced swim test to reverse the effects of learned helplessness?

A
  • buspirone
  • fluoxetine
  • reboxetine
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9
Q

What did the tail suspension test assess? What did it measure?

A

behavioural despair; measure amt of time spent immobile

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10
Q

What kind of drugs were used to prolong attempts to correct positioning in the tail suspension test?

A

antidepressants (SSRIs)

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11
Q

What paradigm is the elevated plus maze based on?

A

rodents would rather be in the enclosed arms

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12
Q

Which anxiolytic drug is used in the elevated plus maze? What class?

A

LORAZEPAM (benzodiazepine)

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13
Q

Which drug increased anxiety in the elevated plus maze? What class?

A

YOHIMIBINE (alpha2 agonist)

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14
Q

Which drug caused a greater latency to enter open arms in the elevated plus maze?

A

yohimbine

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15
Q

What is the vogel conflict test used for?

A

standard for fast screening the potential anxiolytic properties of drugs

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16
Q

How does the vogel conflict test work?

A

drinking behaviour punished by mild electrical shocks –> decrease water consumption –> drinking responses restored with anxiolytic drugs

17
Q

Explain the defensive burying model.

A

probe looks like snake –> triggers defensive burying behaviour –> anxiolytic drugs decrease burying

18
Q

What does the Y maze test?

A

spatial memory

19
Q

What kind of lesions can impair spatial memory?

A

hippocampal lesions

20
Q

What does the morris water maze assess?

A

spatial memory

21
Q

What kind of mouse model was used in the morris water maze?

A

fragile X mouse model

22
Q

What is a reversal trial?

A

task is purposefully made difficult

23
Q

What drugs impair learning and memory?

A

benzodiazepines, scopolamine

24
Q

Which drugs were used to treat impaired spatial memory in the morris water maze?

A

donezipil, rivastigmine, memantine

25
Q

donezipil (aricept)

A

cholinesterase inhibitor

26
Q

Which neurotransmitter is important for memory and thinking skills?

A

ACh

27
Q

rivastigmine (exelon)

A

cholinesterase inhibitor

28
Q

memantine (namenda)

A

regulate activity of glutamate

29
Q

Which neurotransmitter serves to process, store, and retrieve info?

A

glutamate

30
Q

What does the radial arm maze assess?

A

spatial reference and working memory

31
Q

How many are are used in the radial arm maze and how many are blocked?

A

8 arms; 4 blocked

32
Q

What is another name for the radial arm maze?

A

delayed match-to-sample test

33
Q

During which phase of the radial arm maze can a working memory error occur? reference memory error?

A
  • working memory error –> both training and test phase
  • reference memory error –> only test phase
34
Q

What is a working memory error in the radial arm maze? reference memory error?

A
  • working: re-entry of an arm that has been baited
  • reference: entry into arm that was baited during training but no longer baited in test
35
Q

What is a working memory error in the radial arm maze? reference memory error?

A
  • working: re-entry of an arm that has been baited
  • reference: entry into arm that was baited during training but no longer baited in test
36
Q

What does the social interaction test assess? How does it assess this?

A
  • assess sociability
  • can mouse recognize new ‘stranger’ mouse
37
Q

Which test is used as a screen in models for autism, fragile X, schizophrenia, etc.?

A

social interaction test

38
Q

What kind of drugs increase social interaction?

A

anxiolytic compounds: benzodiazepines, ethanol, barbiturates (all GABA agonists)

39
Q

what kind of drugs decrease social interaction?

A

anxiogenic compounds: CRF

PMCOL 343 (27 decks)

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