Cardiopulmonary Pharmacology Flashcards

1
Q

Types of Adrenergic receptors

A
  • Beta1
  • Beta2
  • Alpha1
  • Alpha2
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2
Q

Adrenergic Receptors

A
  • Released by post ganglionic sympathetic neurons
  • Types (B1, B2, A1, A2)
  • Neurotransmitters (NE, E)
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3
Q

Adrenergic Neurotransmitters

A
  • Norepinephrine

- Epinephrine

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4
Q

Nicotinic Receptors

A
  • post ganglionic neuron transmission

- muscle contraction

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5
Q

2 Cholinergic Receptors

A
  • muscarinic

- nicotinic

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6
Q

Muscarinic Receptors cause:

A

-decrease HR (SA, AV & atria)

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7
Q

Anti-Anginal Drugs Work by:

A
  • decreasing myocaridal oxygen demand

- increasing myocardial oxygen supply

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8
Q

Beta Blocker Endings

A

-olol

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9
Q

S=

A

-Selective

Beta1 receptor only

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10
Q

NS=

A

Nonselective

beta1 and beta2 receptors

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11
Q

Alpha1

A
  • many target organs (blood vessels)
  • smooth muscle contraction
  • increases force of heart contraction
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12
Q

Alpha2

A
  • many target organs
  • contracts some smooth muscle
  • presynaptic of NE release
  • inhibition of lipolysis
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13
Q

Beta1

A
  • acts on Heart and fat cells
  • increases HR
  • incr force of heart contraction
  • increase lipolysis
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14
Q

Beta2

A
  • on smooth muscle and ducts
  • Smooth muscle relaxation
  • K+ uptake (skel Mm)
  • glycogenolysis (liver)
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15
Q

Pharmacological Management

A
  • anti-anginals
  • heart failure drugs
  • antiarrhythmias
  • vasopressors
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16
Q

2 Positive Inotropes

A
  • cardiac glycosides

- sympathomimetics

17
Q

8 Hypertensive Drug Types

A
  • diuretics
  • noradrenergics
  • alpha adrenergic blockers
  • centrally acting agents
  • ACE inhibitors
  • Beta blockers
  • Ca++ channel blockers
  • Angiotensin II receptor blockers
18
Q

-Antiarrythmics

A
  • Class I: Na+ channel blockers
  • Class II: Beta blockers
  • Class III: prolong repolarization
  • Class IV: Ca++ channel blockers
  • Digitalis
19
Q

6 Anti-Anginal Drugs

A
  • Beta blockers
  • Nitrates
  • Ca++ channel blockers
  • Thrombolytics
  • Antiplatelets
  • Anticoagulants

(Beta blockers & Nitrates decrease O2 demand; rest increase O2 supply)

20
Q

6 Heart Failure Drugs

A
  • diuretics
  • positive inotropes
  • ACE inhibitors
  • vasodilators
  • beta blockers
  • morphine
21
Q

5 Vasopressors

A
  • Isopeterenol
  • dopamin
  • dobutamine
  • epinephrine
  • NE (Levofed)