cardiomyopathies Flashcards

1
Q

cardiomyopathy

A
  • disorder within the cardiac myocytes themselves
  • typically leads to irreversible decline in function
  • patients with long term cardiomyopathy often candidates for transplant
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2
Q

Predictor for mortality/morbidity with cardiomyopathy?

A

Reduced EF

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3
Q

Types of cardiomyopathy

A

dilated
hypertrophic
restrictive

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4
Q

dilated cardiomyopathy

A

-chamber dilation and contractile impairment = decreased EF and/or SV

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5
Q

dilated cardiomyopathy remodeling

A
  • begins as a ballooning of LV

- often leads to dilation of other chambers

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6
Q

dilated cardiomyopathy remodeling results in

A
  1. heavier
  2. hypertrophied cardiac myocytes
  3. loss of myofibrils
  4. fibrosis
  5. chamber walls thinned
  6. systolic dysfunction/red EF
  7. HF
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7
Q

T/F: dilated is the most common form of cardiomyopathy

A

True

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8
Q

dilated cardiomyopathy causes:

A
  1. genetics
  2. viral infections (HIV)
  3. toxins (ETOH, cocaine, cancer drugs)
  4. metabolic disorders
  5. myocarditis
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9
Q

Dilated Cardiomyopathy sign/symptoms

A

signs:
tachypnea, tachycardia, hyper/hypotension

symptoms:

  • fatigue
  • dyspnea
  • SOB
  • orthopnea
  • paroxysmal nocturnal dyspnea
  • increasing edema, weight, or abdominal growth
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10
Q

dilated cardiomyopathy pertinent findings

A
  • JVD
  • hypoxia (cyanosis, clubbing)
  • pulmonary edema
  • enlarged liver
  • ascites or peripheral edema
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11
Q

nonpharmacological management of dilated cardiomyopathy

A

sodium diet restriction

fluid restriction

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12
Q

dilated cardiomyopathy:

frank-starling law

A

overstretching (increased LVEDV) leads to failure of myocardial contractile unit.

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13
Q

What type of cardiomyopathy is the single most common cause of death in apparently healthy young people?

A

Hypertrophic cardiomyopathy

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14
Q

Hypertrophic cardiomyopathy

A

thickened LV wall with non dilated LV chamber

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15
Q

Hypertrophic cardiomyopathy:

cause

A

genetic disease with autosomal (not sex linked) dominance

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16
Q

How does Hypertrophic cardiomyopathy start?

A
  • Normal BP perceived as excessive by defective myocytes
  • LV free wall hypertrophy to compensate
  • Septal wall may also hypertrophy disrupting normal LV outflow tract
  • heart decompensates
17
Q

T/F: The majority of hypertrophic cardiomyopathy cases are asymptomatic

A

True

18
Q

What is the most common 1st clinical symptom of Hypertrophic cardiomyopathy?

A

sudden death

19
Q

Obstructive HCM

A

septal wall thickens and LV free wall of ventricles stiffen.

obstructs blood flow into aorta

20
Q

Non-obstructive HCM

A
  • walls of LV stiffen
  • reduces LVEDV and SV
  • blood flow isn’t blocked
21
Q

Hypertrophic cardiomyopathy

signs and symptoms

A
  1. chest p!
  2. SOB (especially with physical exertion)
  3. fatigue
  4. arrhythmias
  5. lightheadedness
  6. Fainting
  7. swelling in ankles, feet, legs, abdomen, and veins in neck
22
Q

Hypertrophic cardiomyopathy:

long term complications

A
  1. A-fib
  2. dysrhythmias
  3. HF
  4. History of MIs
23
Q

Hypertrophic cardiomyopathy:

treatment

A
  1. alcohol septal ablation
  2. implantable cardioverter defibrillator
  3. heart transplants
24
Q

Restrictive Cardiomyopathy

A
  1. characterized by diastolic filling/loss of compliance
  2. characterized by idiopathic fibrosis, rigid heart walls, and reduced compliance
  3. systolic function is normal
  4. EDVs diminshed (chambers can’t expand)
  5. ESV and EF normal
  6. SV compromised
  7. Ventricular filling pressures very high
25
Q

Restrictive Cardiomyopathy:

symptoms

A
  • dyspnea w/exertion
  • abdominal swelling
  • ankle edema
  • fatigue
26
Q

Restrictive Cardiomyopathy:

causes

A
  1. scleroderma
  2. amyloidosis
  3. sarcoidosis
  4. diabetes
  5. hemochromatosis
  6. chemotherapeutic agents
  7. radiation (mediastinal)