Cardiac Pathology Flashcards
recent infarcts look how on macro?
not pale
maybe a bit red
in MI, when do neutrophils arrive on scene?
12-24 hours
normal ewight of heart?
300-350g
how to myocytes look in hypertrophic cardiomyopathy?
myocyte disarray
interstitial fibrosis
how does hypertrophic cardiomyopathy kill?
fatal arrythmia
outflow obstruction
who gets hypertrophic cardiomyopathy?
younger patients
usually present before 4th decade
in global ischaemia of brain, what happens to cortex?
cortical thinning from neuronal necrosis
shock will do what to?
Heart?
Liver?
Kidney?
Heart: subendocardial ischaemia
Liver: centrilobular necrosis
Kidney: ATN
what is the most common type of cardiomyopathy?
dilated cardiomyopathy
dilated cardiomyopathy aetiology?
genetic usually
what happens in restrictive cardiomyopathy?
rigid, not thickened ventricles
impaired diastolic filling
5 main groups of cardiomyopathy?
dilated hypertrohpic restrictive arrythmogenic unclassified
what happens in arrythmogenic cardiomyopathy?
cardiomyocytes get replaced by fibrofatty tissue, can’t conduct
what is myocarditis?
inflammation/necrosis of myocytes not from ischaemia
causes of myocarditis?
infection: viral, bacterial sarcoidosis rheumatic fever diptheria drugs transplant rejection
if there are lymphocytes in tissue, think?
virus
people with cardiac sarcoid symptomatic?
usually not:
sudden death definition?
unexpected fatal event within 1hour of onset of symptoms in apparently healthy person
example of mechanical cardiac death?
massive PE
tamponade
aortic rupture
most common cause of sudden cardiac death?
ventricular fibrillation causing arrhythmia
5 causes of coronary artery disease in young people?
congenital vasculitis emboli spontaneous dissection atherosclerosis
2 kinds of vasculitis in CAD in young people?
Kawasaki’s: fever 5
causes of sudden cardiac death in young people?
Coronary artery aortic rupture myocardium morphological conduction abnormalities valves cocaine drugs
5 causes of sudden death in athletes
hypertrophic cardiomypathy congenital coronary artery anomalies aortic rupture/dissection coronary athersclerosi arrhythmogenic cardiomyopathy
