Cardiac Overload (Nichols)

Question 1

How many cells thick is T intima?

Answer 1

2

Question 2

aka necrotic core

Answer 2

lipid core of a plaque

Question 3

neutrophils indicate ______
reach their peak at ______
coagulation necrosis occurs ______

Answer 3

infarction
at day 3 (arrive 6 to 12 hrs)
hours 4 to 12

Question 4

most common cause of sudden death post MI

Answer 4

cardiac arrhythmia

Question 5

contraction band necrosis vs intercalated disks

Answer 5

contraction band: thick wavy band that traverses the entire myocyte

intercalated disk: straight line not the entire length of myocyte

Question 6

interstitial fibrosis is a consequence of

Answer 6

HTN
MI
–> CHF

Question 7

How is interstitial fibrosis differentiated from amyloid?

Answer 7

interstitial fibrosis is focal and amyloid is global

Use trichrome to stain collagen vs congo red for amyloid

Question 8

characteristics of coagulative necrosis?

When do you see it?

Answer 8

hypereosinophillic muscle that lacks striations

less than 6-12 hrs bc there are no neutrophils but more than 4 hrs

Question 9

star shaped cells in loose CT + macrophages + endothelium underneath + blue haze in areas

Answer 9

myxoma

Question 10

collagen laid down that kills myocytes and causing vacuolization

Answer 10

myocytolysis

–>?? MI??

Question 11

multinucleated giant cell + astroid bodies + granuloma

Answer 11

sarcoidosis

how is this diff than aschoff body???

Question 12

extent of fibrosis for reperfused MI??

Answer 12

transmural ???

Question 13

fibrosis + neovascualization + brown pigment laden macrophages

Answer 13

late subacute MI (3 weeks old)

Question 14

compensation

Answer 14

dystolic dysfunction with conserved ejection fraction

Question 15

de-compensation

Answer 15

systolic dysfunction with decreased ejection fraction

Question 16

Heart problem that skips compensation and immediately causes a reduced ejection fraction

Answer 16

large MI