Cardiac output and regulation of cardiac function Flashcards

1
Q

What is the cardiac output?

A

rate at which ventricle pump blood

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2
Q

What is cardiac output formula ?

A

Heart rate * stroke volume

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3
Q

What is extrinsic control?

A

regulation of heart by neural input, hormones

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4
Q

What is intrinsic control ?

A

within heart

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5
Q

How is neural control of cardiac output done?

A

by PNS

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6
Q

what 2 branches does PNS have?

A

Autonomic and Somatic

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7
Q

What is autonomic branches made of ?

A

Sympathetic

Parasympathetic

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8
Q

What is Afferent branch?

A

sensory signals via PNS Into CNS

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9
Q

What is Efferent branch?

A

Motor responses delivered to PNS FROM CNS

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10
Q

What does Somatic branch do?

A

control skeletal muscles

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11
Q

What is neural input from thoracic and lumbar regions?

A

Thoracolumbar

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12
Q

What is Parasympathetic innervation on heart?

A

Vagus nerve to SA/AV nodes so Reduce heart rate via Acetylcholine

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13
Q

What is Sympathetic innervation on heart?

A

Sympathetic nerves to AV/SA nodes and ventricles and Noradrenaline increase heart rate

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14
Q

What does acetylcholine act on?

A

from post ganglionic neurones on pace maker cells

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15
Q

Where is Adrenaline released from ?

A

adrenal medulla via blood stream

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16
Q

What increases heart contractions?

A

thyroid hormones, Glucagon & insulin

17
Q

What does glucagon promote?

A

Increased Heart rate

18
Q

What factors affect Stroke Volume?

A

1) Ventricular contractility
2) End diastolic volume
3) Afterload

19
Q

What increases ventricular contractility?

A
  • increased Sympa. activity so cardiac output increases
  • increased Ca2+ and permeability
  • adrenaline
20
Q

What is End diastolic volume an example of ?

A

Starlings law

21
Q

What is starlings law?

A

rate at which blood flows into heart from veins changes, the heart adjusts its output to match the inflow

22
Q

What does increased EDV mean?

A

increased ventricular contractility so incr. SV and Cardiac output

23
Q

What happens when increased EDV?

A

Myocytes in Vent/ myocardium stretch and lengthen

24
Q

What does myocytes stretching mean?

A

greater affinity of troponin for Ca so greater force of contraction

25
Q

What factors affect EDV?

A

End diastolic pressure = PRELOAD

26
Q

What is Preload?

A

how much volume in ventricle at end of diastole

27
Q

What is preload determined by?

A

filling time

atrial pressure

28
Q

What is Afterload?

A

heart works against arterial pressure to pump blood

29
Q

What does increased arterial pressure mean?

A

Stroke Volume Decreases