Cardiac Lecture 4 Flashcards

1
Q

Which medications are considered mixed vasodilators?

A

Sodium nitroprusside and nitroglycerine (NO donors)

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2
Q

Dilation of the veins decreases ______

A

Psf and RVR

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3
Q

Nitroglycerine relaxes _____ more than ______

A

the veins more than the arteries

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4
Q

What medications are arterial-specific vasodilators?

A

Hydrazaline and ACEi

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5
Q

Which medication is a mixed pressor?

A

Phenylephrine

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6
Q

Describe the body’s compensatory mechanisms for a failing heart

A
  1. Short term:
    Decreased CO → increased sympathetic activity → increased venous tone and HR → increased RAP and CO
  2. Long term:
    Prolonged sympathetic activity → increased fluid retention → increased Psf and RAP → back to normal sympathetic activity
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7
Q

_______ includes the pressures available to fill the heart

A

preload

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8
Q

______ the force that the heart has to overcome to open the aortic valve and eject blood

A

afterload

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9
Q

________ the change in SV when preload and afterload remain constant

A

contractility

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10
Q

______the volume in the ventricle after filling is complete

A

EDV

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11
Q

EDV is a function of _______

A

preload

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12
Q

a normal ESV is _____

A

50 mL

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13
Q

increased preload results in?

A

increased EDV and SV

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14
Q

a normal afterload is ______

A

80 mmHg

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15
Q

How is contractility represented on a pressure-volume loop?

A

the slope at the top left-hand corner of the pressure-volume loop

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16
Q

as contractility increases, the line shifts to the ______ and shifts to the _____ when it decreases

A

left (steeper slope); right

17
Q

increased afterload results in?

A
  • increased ESV and duration of phase II
  • decreased duration of phase III and SV
18
Q

increased contractility results in?

A
  • decreased ESV
  • increased SV, CO, and BP
19
Q

“Everybody has ______ by the time they’re 50”

A

aortic valve stenosis - most common valve problem

20
Q

Describe the effects of aortic valve stenosis on a pressure-volume curve

A

high afterload → increased ESV → decreased SV and CO
- elevated HR to compensate for low CO
increased preload

21
Q

Why would someone with aortic valve stenosis have a normal MAP?

A

the pressure choke point is before the aorta, so the aortic pressure would be lower and could result in a normal MAP

22
Q

You would expect the pulse pressure on someone with aortic valve stenosis to be _______

23
Q

Describe the effects of mitral valve stenosis on a pressure-volume curve

A
  • issues with filling → increased Psf, atrial pressure, and blood volume
  • decreased EDV → decreased SV → increased HR
24
Q

Eventually, mitral valve stenosis will result in ______

A

pulmonary edema

25
Describe the effects of aortic regurgitation on a pressure-volume curve
retrograde blood movement when the valve is closed and pressure in the aorta > ventricle → phase IV not isovolumetric - increased EDV → increased SV - decreased afterload
26
At which point during phase IV does blood flow backward into the ventricle at the greatest speed?
end of phase IV - reflects low pressure in the ventricle bc it's supposed to be empty; slows down as the ventricle fills up
27
What would you expect in the BP of someone with aortic regurgitation?
Wide pulse pressure
28
Describe the effects of mitral regurgitation on a pressure-volume curve
- both phase II and IV not isovolumetric - increased ESV and EDV → increased SV