Cannabis and MS Flashcards

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1
Q

What is the pathophysiology of MS?

A

Multifocal white and grey matter lesions alongside the loss of oligodendrocytes

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2
Q

When does MS usually develop?

A

20-40 years of age

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3
Q

What are the symptoms of MS?

A

Pain, spasms, tremor, incontinence, cognitive deficits, movement deficits. Due to conduction block, demyelination and loss of axons/neurones and synaptic plasticity

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4
Q

How may cannabinoids be used in the treatment of MS?

A

Cannabinoids induce hyperpolarisation which limits the capacity of cells to generate actions potentials, so prevents spasticity due to over-excitation or lack of neural inhibition

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5
Q

How may baclofen be used in the treatment of MS?

A

A GABA-b agonist to encourage inhibition –> treatment of tremor and spasticity

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