Canine viral infections (Yr 2) Flashcards
what type of virus is canine distemper?
morbillivirus
what is the infectious route for distemper?
oronasal
what is the pathogenesis of canine distemper?
infected via respiratory tract, where it multiplies in the respiratory tract and then becomes more widespread in lymphoid issue, bone marrow and spleen
effects epithelial cells eventually
what are clinical signs of canine distemper?
anorexia, depression, pyrexia
ocular/nasal discharge, coughing
vomiting, diarrhoea
hyperkeratosis of nose and feet
neurological signs 1-3 weeks later
how can canine distemper be diagnosed?
history/clinical signs
antibody/antigen in CSF
what type of disease does canine adenovirus 1 cause?
systemic (can also be upper reparatory tract)
what type of disease foes canine adenovirus 2 cause?
respiratory
what does canine adenovirus 1 cause?
infectious hepatitis
what is the pathogenesis of canine adenovirus 1?
oronasal infection that causes a viraemia then localises to the liver to damage hepatic cells and vascular endothelium
what are the clinical signs of canine adenovirus 1?
dogs under a year of age…
pyrexia, depression, lethargy
hepatomegaly, abdominal pain
petechial haemorrhage
haemorrhagic vomiting/diarrhoea
corneal oedema and uveitis
why is canine adenovirus 1 not vaccinated for?
cause problems with blue eyes (corneal oedema)
what cells are attacked by parvovirus?
rapidly dividing cells (intestine, bone marrow…)
what is the pathogenesis of parvovirus?
faecal-oral transmission which replicates in lymphoid tissue then sets up a viraema
replication then occurs in crypts of villi of the intestines causes stinting and loss of villi leading to diarrhoea
what are the clinical signs of parvovirus?
GI - vomiting, diarrhoea (haemorrhagic)
anorexia, depression, pyrexia
dehydration
sepsis and DIC
what would be found of postmortem of a puppy with parvovirus?
intranuclear inclusion bodies in intestinal cells
shortening/loss of villi
depletion of lymphoid tissue in the gut
