Cancers Flashcards
erb-B2 (over-expression)
Breast, ovarian, lung, and stomach cancers
N-myc (over-expression)
Neuroblastoma & small cell carcinoma of lung
L-myc (over-expression)
Small cell carcinoma of lung
int-2 (over-expression)
Bladder cancer, breast cancer, melanoma
cyclin D (over-expression)
Breast, liver, esophageal cancers
t(14;18) translocation
- seen in 80-90% of Follicular Lymphomas (and other non-Hodgkin’s lymphomas)
- B-cell tumor
- Results in BCL-2 overexpression → cancer
t(9;22) rearrangement
Chronic Myelogenous Leukemia (CML)
(& Acute Lymphoblastic Leukemia [ALL])
- BCR-ABL fusion gene directs synthesis of constitutively active Tyrosine Kinase → cancer
t(8:14) translocation
- Burkitt Lymphoma
- C-MYC gene translocation
- diffuse population of medium-sized lymphocytes w/ “starry sky” appearance
fms (point mutation)
Myelodysplastic syndrome
ret (point mutation)
MEN (multiple endocrine neoplasia) 2A and B, familial medullary thyroid carcinoma
ras (point mutation)
Lung, colon, pancreas, leukemias
t(11,14)
Mantle Cell Lymphoma
- Cyclin D gene translocation
Tumor Suppressor mutation on Chromosome 5q
APC: colorectal cancer, pancreatic cancer, melanoma, familial adenomatous polyposis
Tumor Suppressor mutation on Chromosome 9p
p16: melanoma
Tumor Suppressor mutation on Chromosome 11p
WT1: Wilm’s tumor
Tumor Suppressor mutation on Chromosome 13q
Rb: retinoblastoma, osteosarcoma, carcinoma of breast, colon, lung
BRCA2: carcinomas of male & female breast
Tumor Suppressor mutation on Chromosome 17q
NF1: neurofibromatosis type 1
BRCA1: carcinoma of female breast and ovarian cancer
Tumor Suppressor mutation on Chromosome 17
p53: Li-Fraumeni syndrome, most human cancers, multiple carcinomas and sarcomas
Tumor Suppressor mutation on Chromosome 18q
DPC: pancreatic cancer
DCC: colon cancer
Tumor Suppressor mutation on Chromosome 22q
NF2: neurofibromatosis type 2
