Amino Acid Derivatives Flashcards

1
Q

Arginine

A

Nitric Oxide

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2
Q

Arginine + Aspartate

A

Urea

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3
Q

Glycine + Succinyl CoA

A

Heme

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4
Q

Glycine + Arginine + SAM

A

Creatine

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5
Q

Glutamate

A

GABA & Glutathione

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6
Q

Glutamate + Aspartate

A

Pyrimidines

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7
Q

Glutamate + Aspartate + Glycine

A

Purines

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8
Q

Histidine

A

Histamine

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9
Q

Phenylalanine

A

Tyrosine → DOPA → Dopamine

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10
Q

Tryptophan

A

Serotonin → Melatonin
&
Niacin

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11
Q

Tyrosine

A

Thyroxine & Melanin

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12
Q

AAs w/ 3 titratable protons?

have 3 pKas

A

Tyrosine, Cysteine, Arginine, Lysine, Aspartate, Glutamate, Histidine

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13
Q

9 essential amino acids?

A

Histidine, Isoleucine, Leucine, Threonine, Lysine, Methionine, Phenylalanine, Tryptophan, Valine

“Help In Learning These Little Molecules Proves Truly Valuable”

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14
Q

Acidic amino acids?

negatively charged @ physiologic pH

A

Aspartate & Glutamate

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15
Q

Basic amino acids?

Which of these does not have a positive charge @ physiologic pH?

A

Arginine Lysine, & Histidine

(Histidine is not charged @ physiologic pH)

(Arginine & Lysine are over-expressed in histones, b/c they bind negatively-charged DNA)

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16
Q

Exclusively ketogenic AAs?

A

Leucine & Lysine

17
Q

Ketogenic & glucogenic AAs?

A

Threonine, Tryptophan, Tyrosine, Isoleucine, & Phenylalanine

“PITTT” – there are no other AAs that start w/ the letter “T” or “I”. There is one other that starts w/ “P” - proline

18
Q

AAs necessary for purine synthesis?

A

Glutamate, Aspartate, & Glycine

19
Q

AAs necessary for pyrimidine synthesis?

A

Glutamate & Aspartate

20
Q

Urea

A

Arginine & Aspartate

21
Q

Heme

A

Glycine & Succinyl CoA

22
Q

Creatine

A

Glycine, Arginine, & SAM

23
Q

GABA & Glutathione

A

Glutamate

24
Q

Serotonin

A

Tryptophan

25
Q

Melatonin

A

Tryptophan

26
Q

Niacin

A

Tryptophan

27
Q

Thyroxine

A

Tyrosine

28
Q

Melanin

A

Tyrosine

29
Q

Cholesterol metabolism –> bile ACIDS are conjugated to what 2 AAs to make water-soluble bile SALTS?

A

Taurine & Glycine

30
Q

Ammonium transporters (2)?

A

Alanine & Glutamate