Amino Acid Derivatives Flashcards
Arginine
Nitric Oxide
Arginine + Aspartate
Urea
Glycine + Succinyl CoA
Heme
Glycine + Arginine + SAM
Creatine
Glutamate
GABA & Glutathione
Glutamate + Aspartate
Pyrimidines
Glutamate + Aspartate + Glycine
Purines
Histidine
Histamine
Phenylalanine
Tyrosine → DOPA → Dopamine
Tryptophan
Serotonin → Melatonin
&
Niacin
Tyrosine
Thyroxine & Melanin
AAs w/ 3 titratable protons?
have 3 pKas
Tyrosine, Cysteine, Arginine, Lysine, Aspartate, Glutamate, Histidine
9 essential amino acids?
Histidine, Isoleucine, Leucine, Threonine, Lysine, Methionine, Phenylalanine, Tryptophan, Valine
“Help In Learning These Little Molecules Proves Truly Valuable”
Acidic amino acids?
negatively charged @ physiologic pH
Aspartate & Glutamate
Basic amino acids?
Which of these does not have a positive charge @ physiologic pH?
Arginine Lysine, & Histidine
(Histidine is not charged @ physiologic pH)
(Arginine & Lysine are over-expressed in histones, b/c they bind negatively-charged DNA)
Exclusively ketogenic AAs?
Leucine & Lysine
Ketogenic & glucogenic AAs?
Threonine, Tryptophan, Tyrosine, Isoleucine, & Phenylalanine
“PITTT” – there are no other AAs that start w/ the letter “T” or “I”. There is one other that starts w/ “P” - proline
AAs necessary for purine synthesis?
Glutamate, Aspartate, & Glycine
AAs necessary for pyrimidine synthesis?
Glutamate & Aspartate
Urea
Arginine & Aspartate
Heme
Glycine & Succinyl CoA
Creatine
Glycine, Arginine, & SAM
GABA & Glutathione
Glutamate
Serotonin
Tryptophan
Melatonin
Tryptophan
Niacin
Tryptophan
Thyroxine
Tyrosine
Melanin
Tyrosine
Cholesterol metabolism –> bile ACIDS are conjugated to what 2 AAs to make water-soluble bile SALTS?
Taurine & Glycine
Ammonium transporters (2)?
Alanine & Glutamate