Cancer therapy

Question 1

MOA of alkylating agent

Answer 1

binds covalently to DNA, cell-cycle non-specific, most effective against rapidly dividing cells

Question 2

Alkylating agents

Answer 2

cyclophosphamide (nitrogen mustards), cisplatin (platinum compounds)

Question 3

Antimetabolite MOA

Answer 3

analogs of endogenous DNA and RNA precursors.

Cell cycle specific, most effective during S phase

Question 4

Methotrexate MOA

Answer 4

antimetabolite, folic acid analog

Question 5

Types of antimetabolite

Answer 5

folic acid analog, pyrimidine analog, purine analog

Question 6

MOA of anti-tumor antibiotics

Answer 6

1. intercalation of DNA
2. cell cycle non-specific
3. adverse reaction, CHF

Question 7

Antitumor antibiotics

Answer 7

doxorubicin

Question 8

MOA of mitotic inhibitors

Answer 8

interfere with microtubule formation, , block cell cycle arrest in metaphase

Question 9

Specific mitotic inhibitors

Answer 9

vincristine (polymerization) and paclitaxel (depolymerization)

Question 10

MOA of topoisomerase inhibitors

Answer 10

inhibiton of topoisomerases causes double strand breaks. Prevent resealing of of nicked DNA. S phase specific

Question 11

Specific topoisomerase inhibitors

Answer 11

irinotecan

Question 12

MOA of rituximab

Answer 12

binds CD20 antigen, for B cell lymphoma

Question 13

MOA of trastuzumab

Answer 13

binds HER2 receptor

Question 14

MOA of imatinib

Answer 14

inhibits BCR-Abl tyrosine kinase (philadelphia chromosome) in chronic myeloid leukemia

Question 15

Side effects of cytotoxic chemotherapy

Answer 15

A. Myelosuppression
B. GI
C. Alopecia
D. Secondary tumors