Barbituates Flashcards
1
Q
MOA of barbituates
A
bind to barbituate binding site on GABA-A receptors
at high doses can act at GABA site
2
Q
CNS effects
A
reduce anxiety and hypnotic property
hard to separate, unlike benzodiazepines
3
Q
Pharmacokinetics of barbituates
A
strongly induce P450
4
Q
Barbituate intoxication
A
narrow therapeutic index
5
Q
Dependence on barbituates
A
physical dependence can be a serious problem. Tolerance develops to sedative-hypnotic effects, but not toxic effects
