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Pharmacology > Antihyperlipidemic drugs > Flashcards

Antihyperlipidemic drugs Flashcards

1
Q

What is the MOA of atorvastatin

A

Inhibits HMG CoA reductase increasing LDL Receptors

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2
Q

Effects of atorvastatin on lipids

A

decrease LDL*, increase HDL

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3
Q

Side effects of atorvastatin

A

GI, hepatotoxicity, myopathy

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4
Q

Mechanism of Fenofibrate

A

Agonist at PPAR-alpha, increases LP lipase and catabolism of VLDL

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5
Q

Effects of fenofibrate on lipids

A

decrease VLDL, decrease TG*, increse HDL

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6
Q

Side effects of fenofibrate

A

GI, Myosistis (especially in combo with statins)

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7
Q

Best drug for patients with elevated triglycerides

A

fenofibrate

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8
Q

Mechanism of colesevelam

A

Bind bile acids

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9
Q

Effects of colesevelam on lipids

A

decrease LDL, increase HDL

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10
Q

Side effects of colesevelam

A

GI, mild steatorrhea

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11
Q

Mechanism of Niacin

A

inhibit TG lipolysis, decrease TG synthesis, increase LP lipase, decrease clearence of HDL, decrease VLDL production

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12
Q

Effect of niacin on lipids

A

decrease VLDL, decrease TG, decrease LDL, increase HDL

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13
Q

Side effects of niacin

A

flusing, itching, GI, peptic ulcer, hyperglycemia, hyperuricemia, severe hepatotoxicity

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14
Q

MOA of ezetimibe

A

decrease intestinal transport of cholesterol

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15
Q

Effects of ezetimibe on lipids

A

decrease LDL

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16
Q

Side effects of ezetimibe

A

diarrhea

17
Q

Which drugs have a synergistic risk of myopathy

A

atorvastatin, fenofibrate

Pharmacology (35 decks)

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